WormBase Tree Display for Gene: WBGene00004963
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| WBGene00004963 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spe-9 | Person_evidence | WBPerson252 | |||||
| Sequence_name | C17D12.6 | ||||||||
| Molecular_name | C17D12.6a | ||||||||
| C17D12.6a.1 | |||||||||
| CE27074 | |||||||||
| C17D12.6b | |||||||||
| CE42755 | |||||||||
| C17D12.6b.1 | |||||||||
| Other_name | CELE_C17D12.6 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | spe-9 | ||||||||
| DB_info | Database | AceView | gene | 1M176 | |||||
| WormQTL | gene | WBGene00004963 | |||||||
| WormFlux | gene | WBGene00004963 | |||||||
| NDB | locus_tag | CELE_C17D12.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004963|UniProtKB=Q9TVY6 | |||||||
| family | PTHR24033 | ||||||||
| NCBI | gene | 173042 | |||||||
| RefSeq | protein | NM_060554.5 | |||||||
| NM_001136278.3 | |||||||||
| SwissProt | UniProtAcc | Q9TVY6 | |||||||
| UniProt_GCRP | UniProtAcc | Q9TVY6 | |||||||
| OMIM | gene | 605185 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spe | ||||||||
| Reference_allele | WBVar00087760 | ||||||||
| Allele (69) | |||||||||
| Legacy_information | hc52ts : hermaphrodites and males grown at 25x produce motile sperm that are fertilization defective. Self-fertility < 1% (25x) 100% (16x). ES2 (adult). NA2 (hc88ts). | ||||||||
| [C.elegansII] hc52ts : hermaphrodites and males grown at 25C produce motile sperm that are fertilization defective. Self-fertility < 1% (25C) 100% (16C). ES2 (adult). OA3: hc88ts,also nonconditional alleles. [L'Hernault et al. 1988; SL] | |||||||||
| [Singson A] Encodes putative transmembrane protein of 661 aa, with 10 EGF-like repeats. Predicted gene C17D12.6 | |||||||||
| Strain | WBStrain00034092 | ||||||||
| WBStrain00034093 | |||||||||
| WBStrain00034899 | |||||||||
| WBStrain00034903 | |||||||||
| WBStrain00034904 | |||||||||
| WBStrain00034905 | |||||||||
| WBStrain00000377 | |||||||||
| WBStrain00000379 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (26) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | spe-9 encodes an EGF repeat-containing protein with a short intracellular domain; SPE-9 is required autonomously in sperm for fertilization, and by homology, likely mediates an adhesive or signaling event necessary for proper oocyte fertilization; spe-9 mRNA is detected solely in animals that are engaged in spermatogenesis; in spermatids, SPE-9 is found at or near the cell surface; following sperm activation, SPE-9 is found primarily on the pseudopod. | Paper_evidence | WBPaper00003039 | |||||
| WBPaper00024323 | |||||||||
| WBPaper00024329 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Sep 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable signaling receptor binding activity. Involved in single fertilization. Located in several cellular components, including cell surface; cytoplasm; and pseudopodium. Expressed in sperm and spermatid. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; limb ischemia; and temporal arteritis. Is an ortholog of human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:264 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||
| DOID:8947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| DOID:0060227 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| DOID:13375 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2908) | ||||||
| DOID:799 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| DOID:0050852 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| DOID:5241 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
| Molecular_info | Corresponding_CDS | C17D12.6a | |||||||
| C17D12.6b | |||||||||
| Corresponding_CDS_history | C17D12.6:wp47 | ||||||||
| Corresponding_transcript (2) | |||||||||
| Other_sequence | AF049327 | ||||||||
| CR11084 | |||||||||
| CR11085 | |||||||||
| CRC07379_1 | |||||||||
| Associated_feature | WBsf985327 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00002965 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00040793 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3091 | ||||||||
| Expr3092 | |||||||||
| Expr3127 | |||||||||
| Expr14495 | |||||||||
| Expr1017417 | |||||||||
| Expr1032471 | |||||||||
| Expr1144831 | |||||||||
| Expr2016051 | |||||||||
| Expr2034286 | |||||||||
| Construct_product | WBCnstr00017339 | ||||||||
| Antibody | WBAntibody00000756 | ||||||||
| WBAntibody00000878 | |||||||||
| WBAntibody00000886 | |||||||||
| WBAntibody00000887 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (52) | |||||||||
| WBProcess | WBbiopr:00000067 | ||||||||
| Map_info | Map | I | Position | 9.27255 | Error | 0.017081 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | hDf17 | |||||||
| Positive_clone | C17D12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| R12G2 | Author_evidence | Singson AW | |||||||
| Negative | Outside_rearr | dxDf2 | |||||||
| Mapping_data | 2_point | 3197 | |||||||
| Multi_point | 1046 | ||||||||
| 3106 | |||||||||
| 3107 | |||||||||
| 4272 | |||||||||
| 5471 | |||||||||
| Pos_neg_data | 8359 | ||||||||
| 9332 | |||||||||
| 9416 | |||||||||
| 9417 | |||||||||
| Reference (80) | |||||||||
| Remark | spe-9(hc52) fully rescued by R12G2, partially rescued by C17D12. Data extracted from Singson et al. (1998) | ||||||||
| Method | Gene |
