WormBase Tree Display for Gene: WBGene00004271
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| WBGene00004271 | SMap | S_parent | Sequence | W03C9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rab-7 | Person_evidence | WBPerson451 | |||||
| Sequence_name | W03C9.3 | ||||||||
| Molecular_name | W03C9.3 | ||||||||
| W03C9.3.1 | |||||||||
| CE03777 | |||||||||
| Other_name | CELE_W03C9.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | rab-7 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rab | ||||||||
| Allele (25) | |||||||||
| Possibly_affected_by | WBVar02154081 | ||||||||
| WBVar02154082 | |||||||||
| Strain | WBStrain00035667 | ||||||||
| WBStrain00048935 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Contained_in_operon | CEOP2580 | ||||||||
| Ortholog (32) | |||||||||
| Paralog (32) | |||||||||
| Structured_description | Concise_description | rab-7 encodes a Rab GTPase orthologous to the Rab7 GTPases of yeast, Drosophila, and vertebrates; RAB-7 is required for endosome and endosome to lysosome trafficking and thus, for proper yolk protein transport in oocytes and transport of endocytosed materials in coelomoyctes; RAB-7 is also required for apoptotic cell clearance, particularly for regulation of lysosome to phagosome fusion; RAB-7 activity is also required for normal embryogenesis, locomotion, and body morphology; RAB-7 localizes to late endosomes, lysosomes, and phagosomes; RAB-7 localization, and presumably function, at endosomes is positively regulated by SAND-1, a novel, conserved protein required for early to late endosome maturation and transport; rab-7 activity is upregulated by tub-1/tubby, a gene involved in obesity across species, suggesting that rab-7 may also be involved in a tub-1/tubby mediated endocytic pathway for regulation of fat storage. | Paper_evidence | WBPaper00003831 | |||||
| WBPaper00004540 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00027709 | |||||||||
| WBPaper00028972 | |||||||||
| WBPaper00031612 | |||||||||
| WBPaper00037661 | |||||||||
| WBPaper00030935 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Jan 2012 00:00:00 | ||||||||
| Automated_description | Enables GTPase activity. Involved in several processes, including oocyte growth; positive regulation of early endosome to late endosome transport; and vesicle-mediated transport. Located in late endosome membrane; lysosome; and phagocytic vesicle membrane. Expressed in several structures, including oocyte. Used to study obesity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Is an ortholog of human RAB7A (RAB7A, member RAS oncogene family). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00030935 | ||||
| Accession_evidence | OMIM | 601665 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Jan 2013 00:00:00 | ||||||||
| Potential_model | DOID:0110159 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9788) | |||||
| Disease_relevance | Studies in C. elegans suggest that the small Rab GTPase RAB-7 and the Rab-GTPase-activating protein RBG-3 are involved in a tub-1/tubby mediated endocytic pathway that increases fat storage; tub-1/tubby is a gene involved in obesity across species; tub-1 also interacts with RBG-3 in ciliated neurons to possibly modulate neurohormonal and chemosensory function in the regulation of fat storage. | Homo sapiens | Paper_evidence | WBPaper00031329 | |||||
| WBPaper00038404 | |||||||||
| Accession_evidence | OMIM | 203750 | |||||||
| 601665 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 12 Jan 2012 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000028 | ||||||||
| Molecular_info | Corresponding_CDS | W03C9.3 | |||||||
| Corresponding_transcript | W03C9.3.1 | ||||||||
| Other_sequence (45) | |||||||||
| Associated_feature | WBsf650634 | ||||||||
| WBsf666217 | |||||||||
| WBsf224016 | |||||||||
| WBsf224017 | |||||||||
| Experimental_info | RNAi_result (75) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00012363 | ||||||||
| WBCnstr00020664 | |||||||||
| WBCnstr00042405 | |||||||||
| Construct_product (36) | |||||||||
| Antibody (2) | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (96) | |||||||||
| WBProcess | WBbiopr:00000015 | ||||||||
| Map_info | Map | II | Position | 4.64486 | Error | 0.24308 | |||
| Positive | Positive_clone | W03C9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4619 | |||||||
| Pseudo_map_position | |||||||||
| Reference (132) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
