WormBase Tree Display for Gene: WBGene00003883
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| WBGene00003883 | SMap | S_parent | Sequence | T27B1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | osm-1 | Person_evidence (2) | ||||||
| Sequence_name | T27B1.1 | ||||||||
| Molecular_name | T27B1.1 | ||||||||
| T27B1.1.1 | |||||||||
| CE41845 | |||||||||
| Other_name | ift-172 | Person_evidence | WBPerson41163 | ||||||
| CELE_T27B1.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | osm-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 May 2023 12:43:53 | WBPerson51134 | Name_change | CGC_name | osm-1 | ||||
| Other_name | ift-172 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | osm | ||||||||
| Reference_allele | WBVar00095128 | ||||||||
| Allele (173) | |||||||||
| Legacy_information | p808 : fails to avoid 4M fractose or 4 M NaCl; poor chemotaxis to NaCl; normal thermotaxis; fails to take up FITC; severely shortened axonemes ectopic assembly of ciliary structures and microtubules in many sensory neurons. ES1 ME2. NA2 (p816 (similar phenotype lower fertility)). | ||||||||
| See also e1803, e1804, p808, p816 | |||||||||
| [C.elegansII] p808 : fails to avoid 4M fructose or 4M NaCl; poor chemotaxis to NaCl; normal thermotaxis; fails to take up FITC; Daf-d; severely shortened axonemes, ectopic assembly of ciliary structures and microtubules in many sensory neurons. ES1 ME2. OA>10: p816 (similar phenotype, lower fertility), e1803, e1804, p808, p816, m530mut etc. Cloned: encodes predicted 1738 aa protein, very acidic; related to human brain protein of unknown function. [Perkins 1986; Starich et al. 1995] | |||||||||
| Strain | WBStrain00002542 | ||||||||
| WBStrain00002743 | |||||||||
| WBStrain00030795 | |||||||||
| WBStrain00030798 | |||||||||
| WBStrain00034327 | |||||||||
| WBStrain00034395 | |||||||||
| WBStrain00034396 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000490 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | osm-1 encodes a WD- and WAA-repeat containing protein that is the C. elegans ortholog of intraflagellar transport (IFT) complex B component IFT172; OSM-1 is a presumptive cargo molecule for kinesin-II, and OSM-1 is required, along with OSM-6, for the proper assembly of the middle segments of sensory cilia; osm-1 may act in a pathway with avr-14 to affect resistance to ivermectin-induced cessation of pumping, and mutants are defective in avoidance of solutions of high osmotic strength; an OSM-1::GFP fusion protein is expressed in amphid and phasmid chemosensory neurons where it undergoes both anterograde and retrograde intraflagellar transport. | Paper_evidence | WBPaper00000082 | |||||
| WBPaper00000712 | |||||||||
| WBPaper00000932 | |||||||||
| WBPaper00002087 | |||||||||
| WBPaper00003751 | |||||||||
| WBPaper00026698 | |||||||||
| WBPaper00027360 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 23 Feb 2007 00:00:00 | ||||||||
| Automated_description | Involved in dauer entry and non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of intraciliary transport particle B. Expressed in amphid neurons; ciliated neurons; phasmid neurons; and sensory neurons. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Is an ortholog of human IFT172 (intraflagellar transport 172). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110091 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30391) | ||||
| DOID:0081009 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30391) | ||||||
| DOID:0110363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30391) | ||||||
| Molecular_info | Corresponding_CDS | T27B1.1 | |||||||
| Corresponding_CDS_history | T27B1.1:wp88 | ||||||||
| T27B1.1:wp151 | |||||||||
| T27B1.1:wp184 | |||||||||
| Corresponding_transcript | T27B1.1.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf042307 | ||||||||
| WBsf648850 | |||||||||
| WBsf236864 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00067527 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00054271 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066932 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019306 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115875 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002251 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115883 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00003115 | ||||||||
| WBCnstr00004550 | |||||||||
| WBCnstr00017217 | |||||||||
| WBCnstr00035815 | |||||||||
| Construct_product | WBCnstr00005349 | ||||||||
| WBCnstr00011082 | |||||||||
| WBCnstr00035815 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (187) | |||||||||
| Interaction (30) | |||||||||
| WBProcess | WBbiopr:00000012 | ||||||||
| Map_info | Map | X | Position | 24.052 | Error | 0.007697 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | EH#2 | |||||||
| T27B1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 373 | |||||||
| 374 | |||||||||
| 375 | |||||||||
| Multi_point | 1543 | ||||||||
| 4654 | |||||||||
| 4983 | |||||||||
| Pos_neg_data (12) | |||||||||
| Reference (89) | |||||||||
| Method | Gene |
