WormBase Tree Display for Gene: WBGene00003862
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| WBGene00003862 | SMap | S_parent | Sequence | C08H9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | old-1 | Person_evidence | WBPerson295 | |||||
| Sequence_name | C08H9.5 | ||||||||
| Molecular_name | C08H9.5 | ||||||||
| C08H9.5.1 | |||||||||
| CE45789 | |||||||||
| Other_name | tkr-1 | ||||||||
| CELE_C08H9.5 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | old-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | old | ||||||||
| Allele (69) | |||||||||
| Legacy_information | [Murakami S] No mutants known. Transgene overexpression confers increased resistance to heat and UV irradiation, 40-100% increased lifespan. Predicted gene C08H9.5 | ||||||||
| Strain | WBStrain00028925 | ||||||||
| WBStrain00031916 | |||||||||
| WBStrain00034118 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP2460 | ||||||||
| Ortholog (17) | |||||||||
| Paralog (33) | |||||||||
| Structured_description | Concise_description | old-1 encodes a receptor protein tyrosine kinase; old-1 plays a role in stress resistance and regulation of adult lifespan; Murakami and Johnson showed that old-1 mRNA levels are upregulated in response to stress and in daf-2 and age-1 mutant backgrounds and that overexpression of old-1 in wild-type animals results in extended lifespan and increased resistance to heat and UV irradiation; in contrast, Murphy et al., showed that old-1 expression is downregulated in daf-2 mutants and that old-1(RNAi) in an rrf-3 mutant background slightly extends lifespan; an OLD-1::GFP fusion protein is expressed in the anterior region of worms, in neuronal, hypodermal, and pharyngeal tissues, as well as in the proximal region of the male gonad; expression is visible in young adults and appears to increase as animals age and in response to heat, starvation, or UV irradiation. | Paper_evidence | WBPaper00003222 | |||||
| WBPaper00004896 | |||||||||
| WBPaper00005976 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in hypodermis; male gonad; neurons; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and prostate cancer. Is an ortholog of human FLT3 (fms related receptor tyrosine kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||
| DOID:4971 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:0081082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3765) | ||||||
| Molecular_info (5) | |||||||||
| Experimental_info | RNAi_result (8) | ||||||||
| Expr_pattern | Expr2421 | ||||||||
| Expr1021139 | |||||||||
| Expr1144228 | |||||||||
| Drives_construct | WBCnstr00010820 | ||||||||
| WBCnstr00035823 | |||||||||
| Construct_product | WBCnstr00005196 | ||||||||
| WBCnstr00035823 | |||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (69) | |||||||||
| Interaction (35) | |||||||||
| Map_info | Map | II | Position | 1.75151 | Error | 0.007923 | |||
| Positive | Positive_clone | C08H9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C11D5 | Person_evidence | WBPerson439 | |||||||
| Mapping_data | Multi_point | 4559 | |||||||
| Pseudo_map_position | |||||||||
| Reference (35) | |||||||||
| Remark | Data extracted from Murakami & Johnson (1998) | ||||||||
| old-1 and old-2 used to be called tkr-1 and tkr-2. [sdm 31/01/2000] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
