WormBase Tree Display for Gene: WBGene00003241
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| WBGene00003241 | SMap | S_parent | Sequence | T05C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mig-5 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T05C12.6 | ||||||||
| Molecular_name | T05C12.6a | ||||||||
| T05C12.6a.1 | |||||||||
| CE02318 | |||||||||
| T05C12.6b | |||||||||
| CE25100 | |||||||||
| T05C12.6c | |||||||||
| CE28076 | |||||||||
| T05C12.6b.1 | |||||||||
| T05C12.6c.1 | |||||||||
| Other_name | CELE_T05C12.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | mig-5 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mig | ||||||||
| Allele (53) | |||||||||
| Possibly_affected_by | WBVar02153200 | ||||||||
| Legacy_information | [C.elegansII] rh147ts,mat : complex phenotype, abnormal cell migrations; cell lineage and cell fate defects; often two linker cells in male; rh147/Df similar. Both maternal and zygotic rescue. OA1: rh94 (weaker). Cloned: encodes predicted 666 aa intracellular protein, 3 domains with high similarity to Drosophila dsh, discs large. [Hedgecock et al. 1987; NJ] | ||||||||
| Strain | WBStrain00022614 | ||||||||
| WBStrain00034588 | |||||||||
| WBStrain00034589 | |||||||||
| WBStrain00008501 | |||||||||
| WBStrain00008508 | |||||||||
| WBStrain00008509 | |||||||||
| WBStrain00024334 | |||||||||
| WBStrain00052504 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (61) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00001101 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00001102 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. | Paper_evidence | WBPaper00000978 | |||||
| WBPaper00005278 | |||||||||
| WBPaper00005375 | |||||||||
| WBPaper00006419 | |||||||||
| WBPaper00023370 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Nov 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable frizzled binding activity. Involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway. Located in cell cortex. Expressed in several structures, including distal tip cell; linker cell; nerve ring; posterior lateral left ganglion; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060767 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3087) | ||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3087) | ||||||
| DOID:11198 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3084) | ||||||
| DOID:0060765 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3084) | ||||||
| Molecular_info | Corresponding_CDS | T05C12.6a | |||||||
| T05C12.6b | |||||||||
| T05C12.6c | |||||||||
| Corresponding_transcript | T05C12.6a.1 | ||||||||
| T05C12.6b.1 | |||||||||
| T05C12.6c.1 | |||||||||
| Other_sequence (29) | |||||||||
| Associated_feature | WBsf650299 | ||||||||
| WBsf650300 | |||||||||
| WBsf978414 | |||||||||
| WBsf223459 | |||||||||
| WBsf223460 | |||||||||
| WBsf223461 | |||||||||
| WBsf223462 | |||||||||
| Transcription_factor | WBTranscriptionFactor001051 | ||||||||
| Experimental_info | RNAi_result (63) | ||||||||
| Expr_pattern | Expr3956 | ||||||||
| Expr4252 | |||||||||
| Expr12878 | |||||||||
| Expr14632 | |||||||||
| Expr15116 | |||||||||
| Expr1022830 | |||||||||
| Expr1031536 | |||||||||
| Expr1156119 | |||||||||
| Expr2013574 | |||||||||
| Expr2031807 | |||||||||
| Drives_construct | WBCnstr00000993 | ||||||||
| WBCnstr00011860 | |||||||||
| WBCnstr00022805 | |||||||||
| WBCnstr00036165 | |||||||||
| Construct_product | WBCnstr00011860 | ||||||||
| WBCnstr00018604 | |||||||||
| WBCnstr00022805 | |||||||||
| WBCnstr00036165 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (489) | |||||||||
| Map_info | Map | II | Position | 0.749075 | Error | 0.000707 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T05C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3292 | |||||||
| 4617 | |||||||||
| 4965 | |||||||||
| 5546 | |||||||||
| Reference (76) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| WBPicture0000013084 | |||||||||
| Remark | moved further right [jah/sdm 8/99] | ||||||||
| Method | Gene |
