WormBase Tree Display for Gene: WBGene00003031
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| WBGene00003031 | SMap | S_parent | Sequence | R186 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-46 | Person_evidence | WBPerson261 | |||||
| Sequence_name | R186.4 | ||||||||
| Molecular_name | R186.4 | ||||||||
| R186.4.1 | |||||||||
| CE27771 | |||||||||
| Other_name | CELE_R186.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | lin-46 | ||||||||
| DB_info | Database | AceView | gene | 5N449 | |||||
| WormQTL | gene | WBGene00003031 | |||||||
| WormFlux | gene | WBGene00003031 | |||||||
| NDB | locus_tag | CELE_R186.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003031|UniProtKB=G5EF06 | |||||||
| family | PTHR10192 | ||||||||
| NCBI | gene | 179782 | |||||||
| RefSeq | protein | NM_073845.5 | |||||||
| TREEFAM | TREEFAM_ID | TF300902 | |||||||
| TrEMBL | UniProtAcc | G5EF06 | |||||||
| UniProt_GCRP | UniProtAcc | G5EF06 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Allele (33) | |||||||||
| Possibly_affected_by | WBVar02152889 | ||||||||
| WBVar02152890 | |||||||||
| WBVar02153245 | |||||||||
| WBVar02156309 | |||||||||
| WBVar02157244 | |||||||||
| Legacy_information | [C.elegansII] Mutation suppresses Lin-28; some lateral hypodermal cells divide at 4th molt rather than form alae. Enhanced by starvation. [VT] | ||||||||
| [Lee R, Moss EG] Suppressor of lin-28 mutant precocious larval development. Weak retarded larval development phenotype: some lateral hypodermal seam cells divide rather than form alae at L4 molt. Retarded defect enhanced by starvation or growth at 15deg.C (ma164). | |||||||||
| Strain | WBStrain00026482 | ||||||||
| WBStrain00026483 | |||||||||
| WBStrain00040214 | |||||||||
| WBStrain00040225 | |||||||||
| WBStrain00040230 | |||||||||
| WBStrain00047700 | |||||||||
| WBStrain00047698 | |||||||||
| WBStrain00055650 | |||||||||
| In_cluster | conserved_RDE-1_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP5380 | ||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00003384 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003385 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lin-46 encodes one of two C. elegans paralogs of bacterial MoeA proteins and mammalian gephyrins (E domain, only); LIN-46 is predicted to function as a scaffolding protein for a developmental timing complex, and may also play a role in molybdenum cofactor biosynthesis; identified in screens for suppressors of precocious heterochronic mutations in lin-14 and lin-28, lin-46 is required for stage-specific developmental events at the third larval and adult stages of development; as a component of the heterochronic pathway, lin-46 appears to act immediately downstream of lin-28, which encodes a pre-miRNA binding protein required for cell fate specification at the L2 stage; a LIN-46:GFP fusion protein is detected in the cytoplasm and non-nucleolar part of the nucleus of ventral and lateral hypodermal cells around the time of the larval molts; in addition, the LIN-46 fusion protein is detected in cell bodies and axons of the AVBL/R motor interneurons. | Paper_evidence | WBPaper00013416 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Aug 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable molecular adaptor activity and molybdopterin molybdotransferase activity. Involved in regulation of development, heterochronic. Located in cytoplasm and nucleus. Expressed in hypodermis; seam cell; and vulval precursor cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R186.4 | |||||||
| Corresponding_CDS_history | R186.4:wp51 | ||||||||
| Corresponding_transcript | R186.4.1 | ||||||||
| Other_sequence | AF042069 | ||||||||
| Associated_feature (2) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027735 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052013 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12872 | ||||||||
| Expr15684 | |||||||||
| Expr1010496 | |||||||||
| Expr1155653 | |||||||||
| Expr2013188 | |||||||||
| Expr2031420 | |||||||||
| Drives_construct | WBCnstr00036274 | ||||||||
| Construct_product | WBCnstr00023031 | ||||||||
| WBCnstr00036274 | |||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (126) | |||||||||
| Interaction (61) | |||||||||
| WBProcess | WBbiopr:00000083 | ||||||||
| Map_info | Map | V | Position | 4.77373 | Error | 0.002208 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C13D5 | |||||||
| C48E11 | |||||||||
| R186 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Negative_clone | K03G6 | |||||||
| T10B12 | |||||||||
| Mapping_data | Multi_point | 3644 | |||||||
| 4279 | |||||||||
| 4296 | |||||||||
| Reference (50) | |||||||||
| Method | Gene |
