WormBase Tree Display for Gene: WBGene00003025
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| WBGene00003025 | SMap | S_parent | Sequence | T27C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-40 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T27C4.4 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | let-432 | ||||||||
| egr-1 | Paper_evidence | WBPaper00005022 | |||||||
| Person_evidence | WBPerson8 | ||||||||
| CELE_T27C4.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | lin-40 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 01 Mar 2007 13:31:01 | WBPerson2970 | Event | Acquires_merge | WBGene00001219 | ||||
| Name_change | Sequence_name | T27C4.4 | |||||||
| Other_name | egr-1 | ||||||||
| Acquires_merge | WBGene00001219 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Laboratory | BC | ||||||||
| Allele (203) | |||||||||
| Legacy_information | Phenotypes of different homozygous alleles range | ||||||||
| See also e2173, s1053, s1345, s1351, s1352, s1358, s1360, s1373, s1506, s1593, s1611, s1634, s1669, s1675, s1704, s1916 | |||||||||
| [C.elegansII] e2173 : sterile Evl adult, multiple defects; males very abnormal. ES3. ME0. OA>15: s1053 (pka let-432), s1345mut, s1351mut, s1669fdi, s1675fdi, s1704, s1916uvi, etc. Homozygous developmental arrest stages range from early/mid larval lethal to Mel (early larval lethal); sterile and Mel adults are Evl;complex complementation, at least 5 classes; high mutation frequency. Also dominant effects on sperm number (dominant increase in Df/+, decrease in some alleles). [Johnsen and Baillie 1991; BC] | |||||||||
| Strain | WBStrain00026520 | ||||||||
| WBStrain00035816 | |||||||||
| WBStrain00035948 | |||||||||
| WBStrain00035960 | |||||||||
| WBStrain00000693 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP5556 | ||||||||
| CEOP549 | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00001194 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00020320 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017352 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lin-40 encodes, along with egl-27, one of two C. elegans homologs of human MTA1 (metastasis-associated protein), part of a nucleosome remodeling and histone deacetylation (NURD) complex; lin-40 is an essential gene required for proper vulval cell fate specification and morphogenesis; in addition, lin-40 acts with its paralog, egl-27, in regulating posterior ventral hypodermal cell fate specification and embryonic patterning; targets of lin-40 regulation likely include lin-39, which encodes a homeodomain protein also required for vulval cell fate specification. | Paper_evidence | WBPaper00001474 | |||||
| WBPaper00003578 | |||||||||
| WBPaper00004171 | |||||||||
| WBPaper00005022 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Jul 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within chromatin organization; mitochondrial unfolded protein response; and positive regulation of protein localization to nucleus. Located in nucleus. Part of NuRD complex. Expressed in distal tip cell and somatic cell. Is an ortholog of human MTA1 (metastasis associated 1) and MTA3 (metastasis associated 1 family member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T27C4.4a | |||||||
| T27C4.4b | |||||||||
| T27C4.4d | |||||||||
| T27C4.4e | |||||||||
| Corresponding_CDS_history | T27C4.4c:wp246 | ||||||||
| Corresponding_transcript | T27C4.4a.1 | ||||||||
| T27C4.4b.1 | |||||||||
| T27C4.4b.2 | |||||||||
| T27C4.4d.1 | |||||||||
| T27C4.4e.1 | |||||||||
| Other_sequence (37) | |||||||||
| Associated_feature (17) | |||||||||
| Transcription_factor | WBTranscriptionFactor000312 | ||||||||
| Experimental_info | RNAi_result (107) | ||||||||
| Expr_pattern | Expr6787 | ||||||||
| Expr11090 | |||||||||
| Expr14499 | |||||||||
| Expr1025633 | |||||||||
| Expr1031415 | |||||||||
| Expr1157840 | |||||||||
| Expr2013183 | |||||||||
| Expr2031415 | |||||||||
| Drives_construct | WBCnstr00003498 | ||||||||
| Construct_product | WBCnstr00016599 | ||||||||
| WBCnstr00018160 | |||||||||
| Microarray_results (43) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (118) | |||||||||
| Map_info | Map | V | Position | -8.18561 | Error | 0.016186 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T27C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 3131 | |||||||
| 3564 | |||||||||
| Multi_point | 1170 | ||||||||
| 1171 | |||||||||
| 3528 | |||||||||
| 3529 | |||||||||
| 3779 | |||||||||
| 5444 | |||||||||
| 4277 | |||||||||
| Pos_neg_data (17) | |||||||||
| Reference (57) | |||||||||
| Method | Gene |
