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WormBase Tree Display for Gene: WBGene00001259

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Name Class

WBGene00001259SMapS_parentSequenceCHROMOSOME_III
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classemb
Reference_alleleWBVar00087768
Allele (68)
Legacy_informationhc61ts mm : at 25x lima bean arrest misplaced gut granule birefringence; abnormal gastrulation division rates slowed (except E lineage) Ea divides a/p. Normal and defective execution at 24 cell stage. Shift to 25x in L1 results in defective gonadogenesis. Viable at 16x. NA4 (g16ts g65ts : similar to hc61; hc67ts : division rates faster than WT otherwise like hc61).
[C.elegansII] hc61ts,mm : at 25C lima bean arrest misplaced gut granule birefringence; abnormal gastrulation division rates slowed (except E lineage, precocious) Ea divides a/p. Normal and defective execution at 24 cell stage. Shift to 25C in L1 results in defective gonadogenesis. Viable at 16C. Suppressible by mutations in dpy-2,3,7,8,10.OA3: g16ts, g65ts (similar to hc61), hc67ts (division rates faster than WT, otherwise like hc61). Cloned: 5.4 kb transcript, encodes predicted 1521 aa protein, some similarity to yeast nuclear protein SPT6[Miwa et al. 1980; Denich et al. 1984; MJ]
Strain (14)
RNASeq_FPKM (74)
GO_annotation (12)
Contained_in_operonCEOP3216
Ortholog (40)
Structured_descriptionConcise_descriptionemb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4.Paper_evidenceWBPaper00000440
WBPaper00001742
WBPaper00002483
WBPaper00003197
Curator_confirmedWBPerson1843
Date_last_updated26 May 2005 00:00:00
Automated_descriptionPredicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome organization and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Expressed in tail. Is an ortholog of human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST04A8.14
Corresponding_transcriptT04A8.14.1
Other_sequence (22)
Associated_featureWBsf655431
WBsf666817
WBsf666818
WBsf666819
WBsf666820
WBsf992199
WBsf992200
WBsf226566
WBsf226567
Experimental_infoRNAi_result (26)
Expr_patternChronogram690
Expr1514
Expr6589
Expr1027576
Expr1030796
Expr1155968
Expr2011302
Expr2029538
Drives_constructWBCnstr00002898
WBCnstr00037007
Construct_productWBCnstr00037007
Microarray_results (21)
Expression_cluster (143)
Interaction (242)
Map_infoMapIIIPosition-2.78659Error0.024915
Well_ordered
PositivePositive_cloneC56E12
T04A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point222
596
598
Multi_point213
301
496
497
498
2705
2706
3577
5549
Reference (54)
MethodGene