WormBase Tree Display for Gene: WBGene00001259
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WBGene00001259 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | emb | ||||||
Reference_allele | WBVar00087768 | ||||||
Allele (68) | |||||||
Legacy_information | hc61ts mm : at 25x lima bean arrest misplaced gut granule birefringence; abnormal gastrulation division rates slowed (except E lineage) Ea divides a/p. Normal and defective execution at 24 cell stage. Shift to 25x in L1 results in defective gonadogenesis. Viable at 16x. NA4 (g16ts g65ts : similar to hc61; hc67ts : division rates faster than WT otherwise like hc61). | ||||||
[C.elegansII] hc61ts,mm : at 25C lima bean arrest misplaced gut granule birefringence; abnormal gastrulation division rates slowed (except E lineage, precocious) Ea divides a/p. Normal and defective execution at 24 cell stage. Shift to 25C in L1 results in defective gonadogenesis. Viable at 16C. Suppressible by mutations in dpy-2,3,7,8,10.OA3: g16ts, g65ts (similar to hc61), hc67ts (division rates faster than WT, otherwise like hc61). Cloned: 5.4 kb transcript, encodes predicted 1521 aa protein, some similarity to yeast nuclear protein SPT6[Miwa et al. 1980; Denich et al. 1984; MJ] | |||||||
Strain (14) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (12) | |||||||
Contained_in_operon | CEOP3216 | ||||||
Ortholog (40) | |||||||
Structured_description | Concise_description | emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4. | Paper_evidence | WBPaper00000440 | |||
WBPaper00001742 | |||||||
WBPaper00002483 | |||||||
WBPaper00003197 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 26 May 2005 00:00:00 | ||||||
Automated_description | Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome organization and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Expressed in tail. Is an ortholog of human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T04A8.14 | |||||
Corresponding_transcript | T04A8.14.1 | ||||||
Other_sequence (22) | |||||||
Associated_feature | WBsf655431 | ||||||
WBsf666817 | |||||||
WBsf666818 | |||||||
WBsf666819 | |||||||
WBsf666820 | |||||||
WBsf992199 | |||||||
WBsf992200 | |||||||
WBsf226566 | |||||||
WBsf226567 | |||||||
Experimental_info | RNAi_result (26) | ||||||
Expr_pattern | Chronogram690 | ||||||
Expr1514 | |||||||
Expr6589 | |||||||
Expr1027576 | |||||||
Expr1030796 | |||||||
Expr1155968 | |||||||
Expr2011302 | |||||||
Expr2029538 | |||||||
Drives_construct | WBCnstr00002898 | ||||||
WBCnstr00037007 | |||||||
Construct_product | WBCnstr00037007 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (143) | |||||||
Interaction (242) | |||||||
Map_info | Map | III | Position | -2.78659 | Error | 0.024915 | |
Well_ordered | |||||||
Positive | Positive_clone | C56E12 | |||||
T04A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 222 | |||||
596 | |||||||
598 | |||||||
Multi_point | 213 | ||||||
301 | |||||||
496 | |||||||
497 | |||||||
498 | |||||||
2705 | |||||||
2706 | |||||||
3577 | |||||||
5549 | |||||||
Reference (54) | |||||||
Method | Gene |