WormBase Tree Display for Gene: WBGene00000485
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| WBGene00000485 | SMap | S_parent | Sequence | F18C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | che-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F18C12.1 | ||||||||
| Molecular_name | F18C12.1 | ||||||||
| F18C12.1.1 | |||||||||
| CE32386 | |||||||||
| Other_name | osm-2 | ||||||||
| che-8 | |||||||||
| avr-1 | |||||||||
| caf-2 | Person_evidence | WBPerson243 | |||||||
| dhc-2 | Paper_evidence | WBPaper00039784 | |||||||
| CELE_F18C12.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | che-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 22 Sep 2011 10:59:51 | WBPerson2970 | Name_change | Other_name | dhc-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | che | ||||||||
| Reference_allele | WBVar00143763 | ||||||||
| Allele (239) | |||||||||
| Legacy_information | e1124 : non-chemotactic to sodium ion slightly small defective osmotic avoidance defective dauer formation males impotent; ciliated neurons have abnormal stunted ultrastructure no FITC uptake; octopamine deficient. ES2 ME0. NA5 (e1379 e1253 (pka che-8) p801 (pka osm-2) etc.). | ||||||||
| See also e1124, e1253, e1379, p801 | |||||||||
| hf5 : resistant to 30 mM caffeine; no gross phenotype. ES1. NA3. | |||||||||
| [Kari C] caf-2(hf5) is defective in dye (FITC or DiO) filling of amphid and phasmid neurons. | |||||||||
| [C.elegansII] e1124 : non-chemotactic to sodium ion, slightly small; defective osmotic avoidance; defective dauer formation; males impotent; ciliated neurons have abnormal stunted ultrastructure; Dyf (no FITC uptake); octopamine deficient. ES2 ME0. OA>30: e1379, e1253 (pka che-8), p801 (pka osm-2), m443mut, mn333mut,sa129, etc. Also hf5 (pka caf-2, resistant to30 mM caffeine;no gross phenotype; Dyf). High forward mutation frequency. [Lewis and Hodgkin 1977; Starich et al. 1995; NJ; SP; DR] | |||||||||
| Complementation_data | [Kari C] caf-2(hf5) fails to complement che-3(e1124)with respect to dye filling. caf-2(hf5) complements dyf-5(mn400). | ||||||||
| Strain (19) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00000962 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00012272 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00007154 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | che-3 encodes a dynein heavy chain (DHC) 1b isoform that affects the establishment and maintainance of the structural integrity of sensory cilia, and that also has a role in intraflagellar transport; CHE-3 is expressed in ciliated sensory neurons. | Paper_evidence | WBPaper00004136 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable dynein light intermediate chain binding activity and minus-end-directed microtubule motor activity. Involved in several processes, including dauer entry; non-motile cilium assembly; and positive regulation of dauer larval development. Located in non-motile cilium. Expressed in I4 neuron; PDEL; PDER; and nerve ring. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Is an ortholog of human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110087 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2962) | ||||
| DOID:0050592 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2962) | ||||||
| Molecular_info | Corresponding_CDS | F18C12.1 | |||||||
| Corresponding_CDS_history | F18C12.1:wp90 | ||||||||
| Corresponding_transcript | F18C12.1.1 | ||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf984339 | ||||||||
| WBsf219867 | |||||||||
| WBsf219868 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00003406 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00044930 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068236 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr971 | ||||||||
| Expr1023007 | |||||||||
| Expr1030286 | |||||||||
| Expr1148896 | |||||||||
| Expr2009966 | |||||||||
| Expr2028206 | |||||||||
| Drives_construct (3) | |||||||||
| Construct_product | WBCnstr00013829 | ||||||||
| WBCnstr00037501 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (222) | |||||||||
| Interaction (83) | |||||||||
| Map_info | Map | I | Position | 2.44245 | Error | 0.010762 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F18C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| M139 | |||||||||
| Mapping_data | 2_point | 330 | |||||||
| 331 | |||||||||
| 787 | |||||||||
| 2590 | |||||||||
| 2592 | |||||||||
| Multi_point | 719 | ||||||||
| 1698 | |||||||||
| 3042 | |||||||||
| 3043 | |||||||||
| 3044 | |||||||||
| 3045 | |||||||||
| 3232 | |||||||||
| 3233 | |||||||||
| 3234 | |||||||||
| 4159 | |||||||||
| Pos_neg_data | 8303 | ||||||||
| 8304 | |||||||||
| 8305 | |||||||||
| 8306 | |||||||||
| 4521 | |||||||||
| Reference (137) | |||||||||
| Remark | Retire caf-2 gene name. | ||||||||
| Gene name created from parsing 'genotype' field from CGC strain information [krb 020721] | |||||||||
| Method | Gene |
