WormBase Tree Display for Gene: WBGene00000415
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| WBGene00000415 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y47H9C | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ced-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y47H9C.4 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_Y47H9C.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ced-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ced | ||||||||
| Reference_allele | WBVar00144267 | ||||||||
| Allele (516) | |||||||||
| Legacy_information | e1735 : programmed cell deaths abnormal dying cells arrest at highly refractile stage killer cells fail to engulf target cells; no gross phenotype. ES1 NA9 (e1754 n691 etc : all alleles resemble e1735). | ||||||||
| See also n691 | |||||||||
| [C.elegansII] e1735 : programmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group A (ced-1,6,7); no gross phenotype. ES1. OA>10: n1506spo, e1754,e1797, e1798, e1799, e1800, e1801, e1814, n691, n21506, n2000, n2092 (all alleles similar)[Hedgecock et al. 1983; Ellis et al. 1991; MT] | |||||||||
| Strain (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (47) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00013416 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020806 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00011723 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ced-1 encodes a single-pass transmembrane protein homologous to human CD91, a low density lipoprotein receptor; CED-1 is a component of the apoptotic pathway and functions to initiate a signaling pathway in phagocytic cells that promotes cell corpse engulfment, phagosome maturation as evidenced by enrichment of PtdIns(3)P, DYN-1, and RAB-5 on phagosomal surfaces and, ultimately, apoptotic cell degradation; CED-1 is expressed on the plasma membrane, engulfing pseudopodia, and nascent phagosomes; CED-1 interacts physically with the secreted transthyretin-like protein TTR-52 and with CED-6, which colocalizes with CED-1 at at the plasma membrane and around engulfed apoptotic cells. | Paper_evidence | WBPaper00004503 | |||||
| WBPaper00005196 | |||||||||
| WBPaper00005200 | |||||||||
| WBPaper00025002 | |||||||||
| WBPaper00027659 | |||||||||
| WBPaper00031612 | |||||||||
| WBPaper00035888 | |||||||||
| WBPaper00036352 | |||||||||
| WBPaper00037878 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 11 Feb 2011 00:00:00 | ||||||||
| Automated_description | Enables scavenger receptor activity. Involved in several processes, including cytoskeleton organization; left/right axis specification; and phagocytosis. Located in several cellular components, including phagocytic cup; phagocytic vesicle membrane; and pseudopodium membrane. Expressed in body wall musculature; engulfing cell; hyp7 syncytium; and muscle cell. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Is an ortholog of human MEGF10 (multiple EGF like domains 10) and MEGF11 (multiple EGF like domains 11). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111333 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29634) | ||||
| DOID:0081345 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29634) | ||||||
| Molecular_info | Corresponding_CDS | Y47H9C.4a | |||||||
| Y47H9C.4b | |||||||||
| Y47H9C.4c | |||||||||
| Y47H9C.4d | |||||||||
| Corresponding_transcript | Y47H9C.4a.1 | ||||||||
| Y47H9C.4b.1 | |||||||||
| Y47H9C.4c.1 | |||||||||
| Y47H9C.4d.1 | |||||||||
| Other_sequence (39) | |||||||||
| Associated_feature | WBsf649637 | ||||||||
| WBsf665008 | |||||||||
| WBsf985402 | |||||||||
| WBsf985403 | |||||||||
| WBsf1010798 | |||||||||
| WBsf220370 | |||||||||
| WBsf220371 | |||||||||
| WBsf220372 | |||||||||
| WBsf220373 | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr802 | ||||||||
| Expr8903 | |||||||||
| Expr14254 | |||||||||
| Expr1015286 | |||||||||
| Expr1030231 | |||||||||
| Expr1160300 | |||||||||
| Expr2009845 | |||||||||
| Expr2028085 | |||||||||
| Marker40 | |||||||||
| Drives_construct (100) | |||||||||
| Construct_product (12) | |||||||||
| Regulate_expr_cluster | WBPaper00032003:ced-1(e1735)_upregulated | ||||||||
| Antibody | WBAntibody00002104 | ||||||||
| WBAntibody00003055 | |||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (156) | |||||||||
| WBProcess (9) | |||||||||
| Map_info | Map | I | Position | 12.8802 | Error | 0.054441 | |||
| Positive | Positive_clone | Y47H9C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 643 | |||||||
| 644 | |||||||||
| Multi_point | 576 | ||||||||
| 577 | |||||||||
| 1227 | |||||||||
| 1228 | |||||||||
| 1238 | |||||||||
| 3428 | |||||||||
| 5594 | |||||||||
| Pos_neg_data | 3212 | ||||||||
| 3213 | |||||||||
| Reference (300) | |||||||||
| Remark | Sequence connection from [Zhou Z] | ||||||||
| Method | Gene |
