WormBase Tree Display for Gene: WBGene00006606
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| WBGene00006606 | SMap | S_parent | Sequence | LLC1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tra-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | LLC1.1 | ||||||||
| Molecular_name | LLC1.1a | ||||||||
| LLC1.1a.1 | |||||||||
| CE16260 | |||||||||
| LLC1.1b | |||||||||
| Other_name | clp-5 | ||||||||
| CELE_LLC1.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | tra-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tra | ||||||||
| Reference_allele | WBVar00143747 | ||||||||
| Allele (125) | |||||||||
| Legacy_information | e1107amber mat : e1107 daughters of e1107/+ parents are wildtype hermaphrodite e1107 XX progeny of e1107 parents are abnormal sterile males or intersexes occasionally self-fertile especially at 15x (15x brood 1% of wildtype); XO phenotype wildtype. ES3 (progeny testing) ME0 (XX) ME3 (XO). NA4 (e1525amber e1767(non-amber) etc : all alleles resemble e1107). Amber alleles very efficiently suppressed. | ||||||||
| See also e2028, e2333 | |||||||||
| [C.elegansII] e1107amb,mat : XX progeny of homozygous parents are abnormal sterile males or intersexes, occasionally self-fertile, especially at 15C (15C brood 1% of wildtype); XO phenotype wildtype. Either maternal or zygotic expression of tra-3(+) sufficient for normal XX hermaphrodite development. ES3 (progeny testing) ME0 (XX) ME3 (XO). OA>5: e1525amb, e1767(non-amb), y240 etc.(resemble e1107, probable nulls), bn75ts (Mog 25C),e2333 (XX anatomically WT, brood size increased). Amber alleles very efficiently suppressed;used for sup-7 transgene selection. Cloned: encodes predicted protein with similarity to vertebrate protease calpain, but lacking calcium-binding domains. [Hodgkin 1986; Fire 1986; Hodgkin and Barnes 1991; CB] | |||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | tra-3 encodes an atypical calpain regulatory protease that lacks calcium-binding EF hand domains; during development, TRA-3 likely promotes female development in XX hermaphrodites by cleaving the membrane-associated TRA-2A protein to generate a TRA-2 peptide likely to have feminizing activity; in addition, TRA-3 is one of several proteases that mediate necrotic cell death during neurodegeneration. | Paper_evidence | WBPaper00002548 | |||||
| WBPaper00004113 | |||||||||
| WBPaper00005513 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Apr 2007 00:00:00 | ||||||||
| Automated_description | Enables cysteine-type endopeptidase activity. Involved in proteolysis and sex determination. Predicted to be located in cytoplasm. Expressed in several structures, including excretory cell; hypodermis; intestine; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in neovascular inflammatory vitreoretinopathy. Is an ortholog of human CAPN5 (calpain 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9719 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1482) | ||||
| Molecular_info | Corresponding_CDS | LLC1.1a | |||||||
| Corresponding_transcript | LLC1.1b | ||||||||
| LLC1.1a.1 | |||||||||
| Other_sequence (42) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr10020 | ||||||||
| Expr1022748 | |||||||||
| Expr1032737 | |||||||||
| Expr1154408 | |||||||||
| Expr2017477 | |||||||||
| Expr2035616 | |||||||||
| Drives_construct | WBCnstr00014644 | ||||||||
| WBCnstr00034274 | |||||||||
| Construct_product | WBCnstr00014653 | ||||||||
| WBCnstr00014659 | |||||||||
| WBCnstr00034274 | |||||||||
| Antibody | WBAntibody00001581 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (108) | |||||||||
| WBProcess | WBbiopr:00000131 | ||||||||
| Map_info | Map | IV | Position | 12.0984 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | CB#1412 | |||||||
| LLC1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point (4) | ||||||||
| Multi_point | 130 | ||||||||
| 131 | |||||||||
| 762 | |||||||||
| 1619 | |||||||||
| 1620 | |||||||||
| 1621 | |||||||||
| 1622 | |||||||||
| 3407 | |||||||||
| 3995 | |||||||||
| 5062 | |||||||||
| Pos_neg_data | 3269 | ||||||||
| 4680 | |||||||||
| 4692 | |||||||||
| 836 | |||||||||
| 4683 | |||||||||
| Landmark_gene | |||||||||
| Reference | WBPaper00000178 | ||||||||
| WBPaper00000498 | |||||||||
| WBPaper00000563 | |||||||||
| WBPaper00000630 | |||||||||
| WBPaper00000665 | |||||||||
| WBPaper00000724 | |||||||||
| WBPaper00000794 | |||||||||
| WBPaper00000797 | |||||||||
| WBPaper00000922 | |||||||||
| WBPaper00000923 | |||||||||
| WBPaper00000933 | |||||||||
| WBPaper00000943 | |||||||||
| WBPaper00000944 | |||||||||
| WBPaper00001009 | |||||||||
| WBPaper00001013 | |||||||||
| WBPaper00001028 | |||||||||
| WBPaper00001037 | |||||||||
| WBPaper00001077 | |||||||||
| WBPaper00001112 | |||||||||
| WBPaper00001116 | |||||||||
| WBPaper00001206 | |||||||||
| WBPaper00001208 | |||||||||
| WBPaper00001279 | |||||||||
| WBPaper00001400 | |||||||||
| WBPaper00001475 | |||||||||
| WBPaper00001513 | |||||||||
| WBPaper00001544 | |||||||||
| WBPaper00001554 | |||||||||
| WBPaper00001609 | |||||||||
| WBPaper00001629 | |||||||||
| WBPaper00001683 | |||||||||
| WBPaper00001691 | |||||||||
| WBPaper00001692 | |||||||||
| WBPaper00001710 | |||||||||
| WBPaper00001720 | |||||||||
| WBPaper00001772 | |||||||||
| WBPaper00001791 | |||||||||
| WBPaper00001811 | |||||||||
| WBPaper00001813 | |||||||||
| WBPaper00001842 | |||||||||
| WBPaper00001864 | |||||||||
| WBPaper00001883 | |||||||||
| WBPaper00001898 | |||||||||
| WBPaper00001966 | |||||||||
| WBPaper00001982 | |||||||||
| WBPaper00002009 | |||||||||
| WBPaper00002131 | |||||||||
| WBPaper00002278 | |||||||||
| WBPaper00002304 | |||||||||
| WBPaper00002312 | |||||||||
| WBPaper00002493 | |||||||||
| WBPaper00002548 | |||||||||
| WBPaper00002631 | |||||||||
| WBPaper00002662 | |||||||||
| WBPaper00002933 | |||||||||
| WBPaper00003026 | |||||||||
| WBPaper00003279 | |||||||||
| WBPaper00003301 | |||||||||
| WBPaper00003390 | |||||||||
| WBPaper00003739 | |||||||||
| WBPaper00004113 | |||||||||
| WBPaper00004256 | |||||||||
| WBPaper00004448 | |||||||||
| WBPaper00005055 | |||||||||
| WBPaper00005237 | |||||||||
| WBPaper00005513 | |||||||||
| WBPaper00005549 | |||||||||
| WBPaper00005643 | |||||||||
| WBPaper00006018 | |||||||||
| WBPaper00011041 | |||||||||
| WBPaper00011574 | |||||||||
| WBPaper00011843 | |||||||||
| WBPaper00013463 | |||||||||
| WBPaper00013705 | |||||||||
| WBPaper00013706 | |||||||||
| WBPaper00013718 | |||||||||
| WBPaper00013759 | |||||||||
| WBPaper00013765 | |||||||||
| WBPaper00013767 | |||||||||
| WBPaper00013892 | |||||||||
| WBPaper00013937 | |||||||||
| WBPaper00014118 | |||||||||
| WBPaper00014258 | |||||||||
| WBPaper00014259 | |||||||||
| WBPaper00014423 | |||||||||
| WBPaper00014424 | |||||||||
| WBPaper00014435 | |||||||||
| WBPaper00014441 | |||||||||
| WBPaper00014550 | |||||||||
| WBPaper00014681 | |||||||||
| WBPaper00014923 | |||||||||
| WBPaper00015242 | |||||||||
| WBPaper00015243 | |||||||||
| WBPaper00016067 | |||||||||
| WBPaper00016134 | |||||||||
| WBPaper00016275 | |||||||||
| WBPaper00016276 | |||||||||
| WBPaper00016310 | |||||||||
| WBPaper00016363 | |||||||||
| WBPaper00016426 | |||||||||
| WBPaper00016465 | |||||||||
| WBPaper00016482 | |||||||||
| WBPaper00016504 | |||||||||
| WBPaper00016560 | |||||||||
| WBPaper00016569 | |||||||||
| WBPaper00016578 | |||||||||
| WBPaper00016579 | |||||||||
| WBPaper00016580 | |||||||||
| WBPaper00018397 | |||||||||
| WBPaper00018398 | |||||||||
| WBPaper00021064 | |||||||||
| WBPaper00021648 | |||||||||
| WBPaper00021822 | |||||||||
| WBPaper00022106 | |||||||||
| WBPaper00022716 | |||||||||
| WBPaper00023413 | |||||||||
| WBPaper00023661 | |||||||||
| WBPaper00025000 | |||||||||
| WBPaper00025626 | |||||||||
| WBPaper00026694 | |||||||||
| WBPaper00027248 | |||||||||
| WBPaper00027255 | |||||||||
| WBPaper00027294 | |||||||||
| WBPaper00027297 | |||||||||
| WBPaper00027531 | |||||||||
| WBPaper00027793 | |||||||||
| WBPaper00028966 | |||||||||
| WBPaper00029018 | |||||||||
| WBPaper00029148 | |||||||||
| WBPaper00031025 | |||||||||
| WBPaper00031485 | |||||||||
| WBPaper00033634 | |||||||||
| WBPaper00037660 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038921 | |||||||||
| WBPaper00041673 | |||||||||
| WBPaper00043823 | |||||||||
| WBPaper00045700 | |||||||||
| WBPaper00046288 | |||||||||
| WBPaper00048110 | |||||||||
| WBPaper00049138 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055155 | |||||||||
| WBPaper00057998 | |||||||||
| WBPaper00059179 | |||||||||
| WBPaper00062473 | |||||||||
| WBPaper00065135 | |||||||||
| WBPaper00065924 | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Remark | Sequence connection from [Barnes TM, Hodgkin J, Kuwabara PE] | ||||||||
| Method | Gene |
