m63ts : constitutive dauer formation at 25x; reversible by shift to 15x; at all temperatures small and defective in intestinal endosytosis; Type E Egl. ES3 (L3 25x); ES2 (other stages). NA8 (e1364 m72amber etc; all alleles resemble m63).
See also e1364, n957
[C.elegansII] m63ts : constitutive dauer formation at 25C; reversible by shift to 15C; at all temperatures small and defective in intestinal endocytosis, similar to Sma-2; Type E Egl. Weak maternal rescue.ME0: males have crumpled spicules, fused and displaced rays.ES3 (L3 25C); ES2 (other stages). OA7: e1364,m72amb, sa183, sa185, m592ts (ts for Sma) etc; most alleles resemble m63. Cloned : encodes predicted 744 aa receptor Ser/Thr kinase, related to activin, TGF-beta receptor kinases. [Estevez et al. 1993; DR; JT; PB; PJ]
daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, normal adult lifespan, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; thus daf-4 is utilized by both the Dauer TGF-beta pathway and the TGF-beta Sma/Mab pathway; daf-4 also regulates reproductive aging, via the TGF-beta Sma/Mab pathway, mutants of which show a large reproductive span extension; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle.
Enables BMP binding activity. Involved in several processes, including defense response to other organism; regulation of BMP signaling pathway; and regulation of anatomical structure morphogenesis. Located in plasma membrane. Expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; artery disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human ACVR2B (activin A receptor type 2B).