mn163 : hypersensitive to UV not to X irradiation or MMS. Reduced brood size (7% of wildtype) young hermaphrodites lay many inviable eggs. ES1 ME0. NA1.
[C.elegansII] mn163 : hypersensitive to UV not to X irradiation or MMS. Reduced brood size (7% of wildtype), young hermaphrodites lay many inviable eggs. Hypersensitive to paraquat, high oxygen concentration (lethal at 60%) (see also mev); increased lifespan at 16C.ES1 ME0. NA1. [Hartman and Herman 1982; Ishii et al. 1994; TJ; TK; PH]
rad-8 encodes a protein with similarity to dehydrogenases/reductases that is orthologous to the human mitochondrial protein RTN4IP1 (reticulon 4 interacting protein 1); rad-8 was identified in screens for loci that when mutated result in abnormal radiation sensitivity; rad-8 mutant animals are hypersensitive to ultraviolet irradiation, methyl viologen (paraquat) treatment, high concentrations of oxygen (50% or greater), and pathogen infection; young adult rad-8 hermaphrodites produce many inviable embryos, but fertility increases as the animals age; rad-8 mutant animals are also long-lived at 16 degrees C, but not at 20 degrees C; a RAD-8::GFP fusion protein is widely expressed and seen in the neurons, pharynx, muscles, and intestine; a RAD-8::GFP fusion protein localizes to mitochondrion; increased oxygen sensitivity displayed by rad-8 mutants can be rescued by overexpression of human RTN4IP1.
Predicted to enable oxidoreductase activity. Involved in several processes, including defense response to other organism; positive regulation of growth rate; and response to superoxide. Located in mitochondrion. Expressed in several structures, including intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in optic atrophy 10. Is an ortholog of human RTN4IP1 (reticulon 4 interacting protein 1).