WormBase Tree Display for Gene: WBGene00001076

WBGene00001076 Evidence: Person_evidence: WBPerson261
      WBPerson2629
  SMap: S_parent: Sequence: F54D8
  Identity: Version: 2
    Name: CGC_name: dpy-17 Person_evidence: WBPerson261
      Sequence_name: F54D8.1
      Molecular_name: F54D8.1
        F54D8.1.1
        CE11066
      Other_name: CELE_F54D8.1 Accession_evidence: NDB BX284603
      Public_name: dpy-17
    DB_info: Database: AceView gene 3G197
        WormQTL gene WBGene00001076
        WormFlux gene WBGene00001076
        NDB locus_tag CELE_F54D8.1
        Panther gene CAEEL|WormBase=WBGene00001076|UniProtKB=Q20778
          family PTHR24637
        NCBI gene 175696
        RefSeq protein NM_065685.9
        TREEFAM TREEFAM_ID TF321978
        TrEMBL UniProtAcc Q20778
        UniProt_GCRP UniProtAcc Q20778
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dpy
    Reference_allele: WBVar00143004
    Allele (28)
    Legacy_information: e164 : medium dumpy spindle-shaped adult; old adults sometimes less dumpy; strong dumpy L1. ES3 (all stages). ME2. NA7 (e1345ts e905pdi e1295icr etc.).
      See also e164, e417, e2145
      [C.elegansII] e164 : medium dumpy, spindle-shaped adult; old adults sometimes less dumpy; strong dumpy L1; low penetrance defects in outgrowth of posterior canal cell processes. ES3 (all stages). ME2. OA6: e1345ts, e905pdi, e1295icr, e1345, e2145 etc. [Brenner 1974; NJ]
    Strain (204)
    RNASeq_FPKM (74)
    GO_annotation: 00069103
      00069104
      00069105
      00108198
    Ortholog (29)
    Paralog (161)
    Structured_description: Concise_description: dpy-17 encodes a cuticle collagen; during development, dpy-17 activity is required for normal body morphology, hermaphrodite tail development, and outgrowth of posterior canal cell processes; genetic and immunofluorescence studies suggest that extracellular assembly of DPY-17 and the essential SQT-3 cuticle collagen is interdependent, as loss of dpy-17 activity results in intracellular retention of SQT-3 and dpy-17(gf) mutations suppress mutations in dpy-31, which encodes a zinc-metalloprotease predicted to affect C-terminal proteolytic maturation of SQT-3. Paper_evidence: WBPaper00000031
            WBPaper00005485
            WBPaper00027067
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 08 Aug 2006 00:00:00
      Automated_description: Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be part of collagen trimer. Used to study Marfan syndrome. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14323 Homo sapiens Paper_evidence: WBPaper00046710
          Curator_confirmed: WBPerson324
          Date_last_updated: 25 Sep 2015 00:00:00
  Models_disease_in_annotation: WBDOannot00000379
  Molecular_info: Corresponding_CDS: F54D8.1
    Corresponding_transcript: F54D8.1.1
    Other_sequence (37)
    Associated_feature: WBsf645149
      WBsf645150
      WBsf658889
      WBsf658890
      WBsf658891
      WBsf658892
      WBsf658893
      WBsf658894
      WBsf224863
  Experimental_info: RNAi_result: WBRNAi00073110 Inferred_automatically: RNAi_primary
      WBRNAi00002433 Inferred_automatically: RNAi_primary
      WBRNAi00073111 Inferred_automatically: RNAi_primary
      WBRNAi00025629 Inferred_automatically: RNAi_primary
      WBRNAi00048322 Inferred_automatically: RNAi_primary
      WBRNAi00048323 Inferred_automatically: RNAi_primary
      WBRNAi00002758 Inferred_automatically: RNAi_primary
      WBRNAi00032800 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13628
      Expr1018849
      Expr1030684
      Expr1152124
      Expr2011059
      Expr2029296
    Drives_construct: WBCnstr00000440
      WBCnstr00037096
      WBCnstr00039888
    Construct_product: WBCnstr00000440
      WBCnstr00037096
    Microarray_results (19)
    Expression_cluster (311)
    Interaction (64)
    WBProcess: WBbiopr:00000124
  Map_info: Map: III Position: -2.13512 Error: 0.005986
    Well_ordered
    Positive: Inside_rearr: nDp2
        mT1
        ctDp11
      Positive_clone: F54D8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point (41)
      Multi_point: 68
        315
        316
        318
        324
        325
        376
        377
        378
        429
        488
        491
        492
        498
        502
        506
        513
        580
        585
        589
        600
        611
        613
        629
        630
        729
        746
        754
        862
        863
        865
        868
        871
        877
        879
        895
        1078
        1089
        1251
        1363
        1405
        1407
        1412
        1413
        1415
        1419
        1421
        1489
        1491
        1492
        1496
        1497
        1499
        1500
        1503
        1504
        1623
        1624
        1634
        1637
        1669
        1726
        1736
        1754
        1755
        1810
        1817
        1850
        1851
        1853
        2007
        2012
        2013
        2018
        2055
        2074
        2075
        2077
        2078
        2079
        2081
        2082
        2083
        2084
        2085
        2099
        2100
        2102
        2104
        2108
        2151
        2178
        2179
        2223
        2224
        2225
        2242
        2243
        2245
        2247
        2304
        2305
        2307
        2308
        2312
        2425
        2706
        2740
        2741
        2742
        2744
        2755
        2760
        2761
        2791
        2799
        2800
        3015
        3110
        3138
        3166
        3179
        3206
        3217
        3218
        3219
        3223
        3224
        3225
        3235
        3298
        3301
        3304
        3324
        3325
        3326
        3327
        3328
        3329
        3330
        3331
        3332
        3333
        3334
        3335
        3336
        3337
        3338
        3340
        3339
        3468
        3469
        3470
        3471
        3472
        3473
        3474
        3503
        3577
        3578
        3579
        3580
        3581
        3585
        3586
        3587
        3588
        3589
        3590
        3591
        3592
        3593
        3594
        3595
        3596
        3597
        3598
        3601
        3602
        3603
        3618
        3620
        3621
        3622
        3624
        3625
        3667
        3668
        3701
        3712
        3715
        3717
        3718
        3739
        3740
        3741
        3742
        3743
        3744
        3745
        3746
        3747
        3748
        3749
        3750
        3751
        3752
        3753
        3754
        3755
        3756
        3757
        3758
        3759
        3760
        3761
        3763
        3764
        3767
        3768
        3769
        3762
        3765
        3766
        3770
        3771
        3864
        3891
        3893
        3999
        4017
        4036
        4046
        4050
        4052
        4053
        4091
        4094
        5474
        5268
        5559
        5690
        5692
        5712
      Pos_neg_data: 1578
        1582
        1586
        1596
        1616
        3244
        4711
        5141
        8706
  Reference (119)
  Remark: [Smardon A] dpy-17(e164) rescued by sEx271 [F54D8 + pCes1943{rol-6(su1006dm)}]. F54D8.1 encodes predicted protein with C-term similarity to sqt-1 collagen, therefore candidate for dpy-17.
  Method: Gene