WormBase Tree Display for Gene: WBGene00003209
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| WBGene00003209 | SMap | S_parent | Sequence | ZK858 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mel-26 | Person_evidence | WBPerson314 | |||||
| Sequence_name | ZK858.4 | ||||||||
| Molecular_name | ZK858.4a | ||||||||
| ZK858.4a.1 | |||||||||
| CE30580 | |||||||||
| ZK858.4b | |||||||||
| CE48036 | |||||||||
| ZK858.4b.1 | |||||||||
| Other_name | CELE_ZK858.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mel-26 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mel | ||||||||
| Reference_allele | WBVar00054442 | ||||||||
| Allele (40) | |||||||||
| Legacy_information | [Mains PE] ct61sb4 is a recessive maternal-effect lethal. | ||||||||
| [C.elegansII] ct61dm,ts : dominant maternal effect lethal, at 25C most embryos from ct61/+ mothers have early cleavage defects, arrest prior to morphogenesis; at 15C impenetrant maternal effect Vab. More severe defects in progeny from homozygous mothers.OA1: revertant ct61sb4 is a recessive maternal-effect lethal. [Mains et al. 1990; HR] | |||||||||
| [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. | |||||||||
| Complementation_data | [Bowerman BA] fails to complement mel-26(ct61sb4) | ||||||||
| Strain | WBStrain00007337 | ||||||||
| WBStrain00007344 | |||||||||
| WBStrain00007292 | |||||||||
| WBStrain00008461 | |||||||||
| WBStrain00008453 | |||||||||
| WBStrain00008446 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (67) | |||||||||
| Ortholog (61) | |||||||||
| Paralog | WBGene00011815 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015567 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00016803 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018137 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00006415 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013689 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015463 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis. | Paper_evidence | WBPaper00004129 | |||||
| WBPaper00004589 | |||||||||
| WBPaper00005262 | |||||||||
| WBPaper00019282 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables several functions, including cullin family protein binding activity; identical protein binding activity; and protein kinase binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of TORC1 signaling; and protein metabolic process. Located in several cellular components, including cleavage furrow; condensed chromosome; and sarcomere. Expressed in germ line and muscle cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK858.4a | |||||||
| ZK858.4b | |||||||||
| Corresponding_CDS_history | ZK858.4:wp77 | ||||||||
| Corresponding_transcript | ZK858.4a.1 | ||||||||
| ZK858.4b.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf976886 | ||||||||
| WBsf976887 | |||||||||
| WBsf976888 | |||||||||
| WBsf984593 | |||||||||
| WBsf984594 | |||||||||
| WBsf984595 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr3764 | ||||||||
| Expr7812 | |||||||||
| Expr8642 | |||||||||
| Expr10196 | |||||||||
| Expr1019026 | |||||||||
| Expr1031515 | |||||||||
| Expr1163213 | |||||||||
| Expr2013517 | |||||||||
| Expr2031751 | |||||||||
| Drives_construct | WBCnstr00036185 | ||||||||
| Construct_product | WBCnstr00014789 | ||||||||
| WBCnstr00036185 | |||||||||
| Antibody | WBAntibody00000665 | ||||||||
| WBAntibody00001174 | |||||||||
| WBAntibody00001632 | |||||||||
| WBAntibody00001917 | |||||||||
| WBAntibody00001918 | |||||||||
| Microarray_results | SMD_ZK858.4 | ||||||||
| SMD_ZK858.4:2 | |||||||||
| 175252_at | |||||||||
| 193391_at | |||||||||
| A_12_P118082 | |||||||||
| Aff_ZK858.4 | |||||||||
| GPL13394_WBGene00003209 | |||||||||
| GPL13914_ZK858.4 | |||||||||
| GPL14144_ZK858.4_663-722_0.919_10_C | |||||||||
| GPL14144_ZK858.4_806-865_0.920_9_B | |||||||||
| GPL14144_ZK858.4_895-954_0.944_4_A | |||||||||
| GPL19516_CGZ0057682 | |||||||||
| GPL19516_CGZ0057683 | |||||||||
| GPL21109_ZK858.4a | |||||||||
| GPL21109_ZK858.4b | |||||||||
| GPL3518_CE30580 | |||||||||
| GPL8304_CE_WBGene00003209_A | |||||||||
| GPL8304_CE_WBGene00003209_B | |||||||||
| GPL8673_ZK858_4P00117 | |||||||||
| GPL8673_ZK858_4P00677 | |||||||||
| GPL8673_ZK858_4P01007 | |||||||||
| GPL9450_ZK858.4 | |||||||||
| cea2.p.27145 | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (247) | |||||||||
| Map_info | Map | I | Position | 3.61757 | Error | 0.007042 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK858 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Negative_clone | C08H1 | |||||||
| D1004 | |||||||||
| F25H5 | |||||||||
| W04H6 | |||||||||
| W06D4 | |||||||||
| Mapping_data | Multi_point | 1769 | |||||||
| 2277 | |||||||||
| 2285 | |||||||||
| 3008 | |||||||||
| 3157 | |||||||||
| 3313 | |||||||||
| Reference (75) | |||||||||
| Remark | Sequence connection from email by PE Mains [krb 020719] | ||||||||
| Method | Gene |
