WormBase Tree Display for Gene: WBGene00006773
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WBGene00006773 | SMap | S_parent | Sequence | W02D3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-37 | Person_evidence | WBPerson261 | |||||
Sequence_name | W02D3.9 | ||||||||
Molecular_name | W02D3.9 | ||||||||
W02D3.9.1 | |||||||||
CE14434 | |||||||||
Other_name | let-76 | ||||||||
ESG | Accession_evidence | EMBL | AF001271 | ||||||
AF001272 | |||||||||
CELE_W02D3.9 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | unc-37 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143071 | ||||||||
Allele (43) | |||||||||
Legacy_information | e262 : weak coiler fairly active. ES2 ME1. NA1. | ||||||||
s80 : L1 lethal. NA1. | |||||||||
L1 lethal | |||||||||
See also s80 | |||||||||
[C.elegansII] e262 : weak coiler, fairly active; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993; NC] | |||||||||
Strain (15) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (35) | |||||||||
Contained_in_operon | CEOP1348 | ||||||||
Ortholog (54) | |||||||||
Structured_description | Concise_description | unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex. | Paper_evidence | WBPaper00002798 | |||||
WBPaper00005042 | |||||||||
WBPaper00005136 | |||||||||
WBPaper00030973 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 07 May 2010 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in chemical synaptic transmission; regulation of axonogenesis; and regulation of synapse structure or activity. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30788) | ||||
Molecular_info | Corresponding_CDS | W02D3.9 | |||||||
Corresponding_transcript | W02D3.9.1 | ||||||||
Other_sequence | AS02185 | ||||||||
TS01461 | |||||||||
CR00468 | |||||||||
HGC06443_1 | |||||||||
CR04277 | |||||||||
CB043168.1 | |||||||||
BMC07719_1 | |||||||||
WBC02253_1 | |||||||||
HC01923 | |||||||||
Oden_isotig17202 | |||||||||
DI01019 | |||||||||
JI178375.1 | |||||||||
MJ00927 | |||||||||
SSC00357_1 | |||||||||
Oden_isotig10800 | |||||||||
TDC00320_1 | |||||||||
Dviv_isotig23176 | |||||||||
MI08713 | |||||||||
AM743474.1 | |||||||||
MIC09027_1 | |||||||||
HCC01974_1 | |||||||||
Oden_isotig17201 | |||||||||
HC07921 | |||||||||
Oden_isotig10798 | |||||||||
AYC03930_1 | |||||||||
GR977602.1 | |||||||||
TLC00112_1 | |||||||||
PPC09679_1 | |||||||||
CJC02003_1 | |||||||||
SSC03577_1 | |||||||||
ACC37812_1 | |||||||||
ACC00372_1 | |||||||||
EX557826.1 | |||||||||
JI477374.1 | |||||||||
TX01780 | |||||||||
Acan_isotig07643 | |||||||||
SC01237 | |||||||||
CRC04136_1 | |||||||||
ASC13433_1 | |||||||||
FE909422.1 | |||||||||
Acan_isotig16185 | |||||||||
CV200327.1 | |||||||||
EW742854.1 | |||||||||
SS03462 | |||||||||
Oden_isotig10799 | |||||||||
Name_isotig04969 | |||||||||
CK855083.1 | |||||||||
ES880477.1 | |||||||||
JI482966.1 | |||||||||
Tcir_isotig12188 | |||||||||
BE420439.1 | |||||||||
ACC03169_1 | |||||||||
CRC00507_1 | |||||||||
CR00368 | |||||||||
CBC04706_1 | |||||||||
PVC01126_1 | |||||||||
OVC06752_1 | |||||||||
FC541146.1 | |||||||||
DIC00423_1 | |||||||||
TSC07879_1 | |||||||||
FG584383.1 | |||||||||
AS00556 | |||||||||
ES565236.1 | |||||||||
AE04897 | |||||||||
Tcol_isotig16407 | |||||||||
Hbac_isotig02588 | |||||||||
MJC00450_1 | |||||||||
CK854889.1 | |||||||||
EX556188.1 | |||||||||
SS00234 | |||||||||
Tcol_isotig26488 | |||||||||
CR03422 | |||||||||
HG06205 | |||||||||
JI169656.1 | |||||||||
TSC05408_1 | |||||||||
NAC00126_1 | |||||||||
CB039007.1 | |||||||||
PPC15251_1 | |||||||||
BXC06143_1 | |||||||||
Dviv_isotig25555 | |||||||||
Associated_feature | WBsf034259 | ||||||||
WBsf649254 | |||||||||
WBsf664356 | |||||||||
WBsf664357 | |||||||||
WBsf664358 | |||||||||
WBsf983991 | |||||||||
WBsf1009987 | |||||||||
WBsf219629 | |||||||||
WBsf219630 | |||||||||
Transcription_factor | WBTranscriptionFactor000434 | ||||||||
Experimental_info | RNAi_result (34) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00002546 | ||||||||
WBCnstr00004371 | |||||||||
WBCnstr00006094 | |||||||||
WBCnstr00006107 | |||||||||
WBCnstr00006110 | |||||||||
WBCnstr00010892 | |||||||||
Construct_product | WBCnstr00006110 | ||||||||
WBCnstr00010892 | |||||||||
Antibody | WBAntibody00000145 | ||||||||
Microarray_results | SMD_W02D3.9 | ||||||||
173188_s_at | |||||||||
173509_at | |||||||||
193614_s_at | |||||||||
A_12_P111251 | |||||||||
Aff_W02D3.9 | |||||||||
GPL13394_WBGene00006773 | |||||||||
GPL13914_W02D3.9 | |||||||||
GPL14144_W02D3.9_1348-1407_0.939_5_B | |||||||||
GPL14144_W02D3.9_1464-1523_0.930_8_C | |||||||||
GPL14144_W02D3.9_1632-1691_0.950_2_A | |||||||||
GPL19516_CGZ0037980 | |||||||||
GPL19516_CGZ0037981 | |||||||||
GPL21109_W02D3.9.1 | |||||||||
GPL3518_CE14434 | |||||||||
GPL8304_CE_WBGene00006773_A | |||||||||
GPL8304_CE_WBGene00006773_C | |||||||||
GPL8673_W02D3_9P00594 | |||||||||
GPL8673_W02D3_9P00784 | |||||||||
GPL8673_W02D3_9P01606 | |||||||||
GPL9450_W02D3.9 | |||||||||
cea2.c.06677 | |||||||||
Expression_cluster (138) | |||||||||
Interaction (324) | |||||||||
Map_info | Map | I | Position | 1.30432 | Error | 0.000643 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | qDf16 | |||||||
nDp1 | |||||||||
Positive_clone | W02D3 | Person_evidence | WBPerson422 | ||||||
WBPerson43 | |||||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | 2_point | 15 | |||||||
7055 | |||||||||
Multi_point (24) | |||||||||
Pos_neg_data (41) | |||||||||
Reference (129) | |||||||||
Remark | [Miller D and Barnes T] unc-37 encodes a homolog of Drosophila groucho and therefore is likely to function as a transcription cofactor protein. | ||||||||
Method | Gene |