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WormBase Tree Display for Gene: WBGene00002004

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Name Class

WBGene00002004EvidencePaper_evidenceWBPaper00005342
SMapS_parentSequenceY53C10A
IdentityVersion1
NameCGC_namehsf-1Person_evidenceWBPerson1157
Sequence_nameY53C10A.12
Molecular_nameY53C10A.12
Y53C10A.12.1
CE22380
Y53C10A.12.2
Other_nameCELE_Y53C10A.12Accession_evidenceNDBBX284601
Public_namehsf-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhsf
Allele (276)
Possibly_affected_byWBVar02153033
Strain (20)
RNASeq_FPKM (74)
GO_annotation00018735
00018736
00018737
00018738
00018739
00018740
00018741
00018742
00018743
00018744
00018745
00018746
00018747
00018748
00018749
00018750
00018751
00018752
00018753
00018754
00018755
00018756
00018757
00018758
00018759
00018760
00018761
00018762
00018763
00018764
00018765
00018766
00018767
00018768
00018769
00018770
00018771
00018772
00018773
00018774
00018775
00018776
00018777
00018778
00018779
00018780
00018781
00018782
00018783
00018784
00018785
00018786
00018787
00018788
00018789
00018790
00018791
00018792
00018793
00018794
00018795
00018796
00018797
00018798
00018799
00018800
00018801
00018802
00018803
00018804
00018805
00018806
00018807
00018808
00018809
00018810
00018811
00018812
00018813
00018814
00018815
00018816
00018817
00018818
00018819
00018820
00018821
00018822
00109866
00109867
00109868
Ortholog (42)
Structured_description (2)
Disease_infoPotential_modelDOID:12858Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5224)
DOID:0110255Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5227)
DOID:83Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5227)
Disease_relevanceC. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes.Homo sapiensPaper_evidenceWBPaper00041564
Curator_confirmedWBPerson324
Date_last_updated29 May 2013 00:00:00
Molecular_infoCorresponding_CDSY53C10A.12
Corresponding_transcriptY53C10A.12.1
Y53C10A.12.2
Other_sequence (32)
Associated_featureWBsf665013
WBsf717585
WBsf978924
WBsf985423
WBsf220382
Gene_product_bindsWBsf919560
WBsf919561
WBsf919565
WBsf919566
WBsf919567
WBsf919568
WBsf919569
WBsf919570
WBsf919571
Transcription_factorWBTranscriptionFactor000178
Experimental_info (11)
Map_infoMapIPosition13.0131Error0.000976
PositivePositive_cloneY53C10AInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4416
5648
Reference (373)
MethodGene