WormBase Tree Display for Gene: WBGene00001592
expand all nodes | collapse all nodes | view schema
WBGene00001592 | SMap | S_parent | Sequence | F25F8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | glc | ||||||
Allele (45) | |||||||
Strain | WBStrain00028915 | ||||||
WBStrain00035700 | |||||||
WBStrain00036012 | |||||||
WBStrain00035006 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00057540 | ||||||
00057541 | |||||||
00057542 | |||||||
00057543 | |||||||
00057544 | |||||||
00057545 | |||||||
00057546 | |||||||
00057547 | |||||||
00057548 | |||||||
00057549 | |||||||
00057550 | |||||||
00057551 | |||||||
00057552 | |||||||
00057553 | |||||||
00057554 | |||||||
00057555 | |||||||
00057556 | |||||||
00057557 | |||||||
00057558 | |||||||
00057559 | |||||||
00057560 | |||||||
00057561 | |||||||
00109066 | |||||||
00109067 | |||||||
00109068 | |||||||
00109069 | |||||||
00109070 | |||||||
00109071 | |||||||
Ortholog (51) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | glc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping. | Paper_evidence | WBPaper00002049 | |||
WBPaper00002808 | |||||||
WBPaper00006139 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables extracellularly glutamate-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in pm4. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||
DOID:0060696 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4326) | ||||
Molecular_info | Corresponding_CDS | F25F8.2 | |||||
Corresponding_transcript | F25F8.2.1 | ||||||
Other_sequence (24) | |||||||
Associated_feature | WBsf983527 | ||||||
WBsf1009726 | |||||||
WBsf219327 | |||||||
WBsf219328 | |||||||
Experimental_info | RNAi_result | WBRNAi00045520 | Inferred_automatically | RNAi_primary | |||
WBRNAi00045519 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085185 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003451 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027617 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1471 | ||||||
Expr1017586 | |||||||
Expr1030954 | |||||||
Expr1149437 | |||||||
Expr1200289 | |||||||
Expr2012080 | |||||||
Expr2030316 | |||||||
Drives_construct | WBCnstr00036840 | ||||||
Construct_product | WBCnstr00036840 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (108) | |||||||
Interaction (17) | |||||||
Map_info | Map | I | Position | -0.683729 | Error | 0.00921 | |
Positive | Positive_clone | F25F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4347 | |||||
4424 | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00002049 | ||||||
WBPaper00002808 | |||||||
WBPaper00005494 | |||||||
WBPaper00006139 | |||||||
WBPaper00015744 | |||||||
WBPaper00015746 | |||||||
WBPaper00018588 | |||||||
WBPaper00027150 | |||||||
WBPaper00027154 | |||||||
WBPaper00027274 | |||||||
WBPaper00030361 | |||||||
WBPaper00032108 | |||||||
WBPaper00034763 | |||||||
WBPaper00036026 | |||||||
WBPaper00038422 | |||||||
WBPaper00038491 | |||||||
WBPaper00042929 | |||||||
WBPaper00044702 | |||||||
WBPaper00048078 | |||||||
WBPaper00051057 | |||||||
WBPaper00053271 | |||||||
WBPaper00055090 | |||||||
WBPaper00060850 | |||||||
WBPaper00062022 | |||||||
WBPaper00062104 | |||||||
Remark | sequence connection from [Vassilatis DK] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |