WormBase Tree Display for Gene: WBGene00000068

WBGene00000068 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F17C8
  Identity: Version: 1
    Name: CGC_name: acy-1 Person_evidence: WBPerson1139
      Sequence_name: F17C8.1
      Molecular_name: F17C8.1
        F17C8.1.1
        CE00955
      Other_name: sgs-1
        CELE_F17C8.1 Accession_evidence: NDB BX284603
      Public_name: acy-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acy
    Allele (122)
    Legacy_information: [Berger AJ, Kaplan JM] nu327 is semidominant suppressor of neurodegeneration induced by constitutive G alpha s. No conspicuous behavioral or other phenotype, odorant response to isoamyl alcohol slightly impaired. OA2: nu329, nu343 similar. Encodes adenylyl cyclase, 40% identical to mammalian adenylyl cyclases. nu327 missense, nu329 and nu343 splice donor mutations. Predicted gene F17C8.1
      [Korswagen HC] pk301 (pka sgs-1) suppresses neuronal degeneration induced by activated G alpha s. No obvious defects in development or behavior. Loss-of-function mutation in predicted adenylyl cyclase. OA8: pk310, pk311, pk450::Tc1, etc., all similar.
    Strain (14)
    RNASeq_FPKM (74)
    GO_annotation: 00064977
      00064978
      00064979
      00064980
      00064981
      00064982
      00064983
      00064984
      00064985
      00064986
      00064987
      00064988
      00064989
      00064990
      00064991
      00064992
      00064993
      00064994
      00064995
      00064996
      00106722
      00106723
    Ortholog (34)
    Paralog (36)
    Structured_description: Concise_description: acy-1 encodes an adenylyl cyclase that is most closely related to the divergent mouse isoform type IX; acy-1 is required for viability, muscle contraction, locomotion, molting, and regulation of sleep-like behavior (lethargus) during larval development; acy-1 acts genetically downstream of gsa-1 and is expressed in excitable cells. Paper_evidence: WBPaper00003038
            WBPaper00003207
            WBPaper00031383
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 06 Nov 2008 00:00:00
      Automated_description: Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:240)
  Molecular_info: Corresponding_CDS: F17C8.1
    Corresponding_transcript: F17C8.1.1
    Other_sequence: GO253036.1
      GO249362.1
      CV201007.1
      EL888691.1
      Oden_isotig25080
      FE913804.1
      JI462884.1
      JI179736.1
      TM01627
      TCC00534_1
      JI213625.1
      JI215436.1
      JI230051.1
      AE04307
      MH08111
      MJ01345
      DA03988
      JI171481.1
      EL889162.1
      AS08912
      EU263331.1
      BG467520.1
      MH08534
      DI01200
      RS09992
      NAC00331_1
      MI00911
      MJ03867
      JI212197.1
      JI175108.1
      JI171487.1
      MHC08249_1
      GO239624.1
      JI165719.1
      TX01052
      AS08641
      EU523698.1
      ASC04560_1
      JI179102.1
      DI00289
      JI181509.1
      EL889242.1
      EL889363.1
      JI179634.1
      DN190289.1
      JI211082.1
      JI219501.1
      HCC08706_1
      Oden_isotig19808
      EY462565.1
      FE919951.1
      GRC00800_1
      GP01902
      CV200463.1
      ES672668.1
      GT570788.1
      EL889248.1
      FG354866.1
      GP01020
      BMC05360_1
      DW718205.1
      JI168652.1
      DW718581.1
      AS01406
      MJ02990
      AS09551
      FC541258.1
      GR12077
      Dviv_isotig14918
      BE225486.1
      Hbac_isotig02425
      EL890441.1
      CRC12386_1
      FC541955.1
      ASC14582_1
      MJ01863
      CV200719.1
      CV199345.1
      TCC01226_1
      MH07553
      MH10106
      EL888852.1
      MJ04178
      JI171541.1
      MJ04583
      AS10555
      AS10566
      EL889631.1
      EY469658.1
      DI01252
      DW718586.1
      TX01917
      DN190200.1
      AS00527
      MH08081
      JI214952.1
      AS10397
      MH10474
      JI179278.1
      FC540903.1
      FE908347.1
      ES567466.1
      SR02750
      ASC07262_1
      JI218284.1
      EL890818.1
      GO250836.1
      GT571190.1
      DW718316.1
      ASC04377_1
      PP00320
      JI167627.1
      RSC04081_1
      MA01340
      ASC11260_1
      BXC00393_1
      FC544663.1
      ACC06399_1
      AS16537
      EL888460.1
      Acan_isotig21788
      MP01049
      EX563037.1
      TSC07962_1
      FK802035.1
      GR13220
      JI231556.1
      Acan_isotig00848
      MCC03563_1
      GP02396
      MHC08205_1
      ES561909.1
      Dviv_isotig14919
      AS17739
      GT571553.1
      GO252872.1
      JI165425.1
      FE919966.1
      TX00437
      MH10666
      FE909033.1
      JI218043.1
      CA953558.1
      EL890753.1
      NAC02709_1
      Name_isotig05310
      PT01626
      JI180526.1
      FG352439.1
      MJ02271
      MJ03301
      EF636489.1
      BE239032.1
      ASC04250_1
      JI176618.1
      FE908777.1
      GO239252.1
      JI181850.1
      PT04099
      JI174514.1
      EL888759.1
      MP01024
      CR00226
      Acan_isotig00847
      XI01223
      PT04020
      JI255403.1
      JI182383.1
      ASC06614_1
      TMC01314_1
      MJ02848
      Tcir_isotig04844
      FE919171.1
      HC08332
      AS02360
      MJ02776
      ASC00025_38
      Name_isotig04814
      CR08657
      JI180357.1
      ASC00550_1
      JI215162.1
      EL890621.1
      EL887586.1
      BI784346.1
      EL889444.1
      JI180070.1
      MH04121
      ASC02237_1
      Tcol_isotig06740
      AY242523.1
      GRC02359_1
      MJ02396
      FE906704.1
      JI215791.1
      Acan_isotig08206
      JI224918.1
      JI164999.1
      MP01336
      MP01015
      Acan_isotig10957
    Associated_feature (11)
  Experimental_info: RNAi_result (19)
    Expr_pattern: Expr592
      Expr1436
      Expr14482
      Expr1015096
      Expr1030029
      Expr1148848
      Expr2009227
      Expr2027464
    Drives_construct: WBCnstr00000278
      WBCnstr00010276
      WBCnstr00015084
      WBCnstr00037756
      WBCnstr00040905
    Construct_product: WBCnstr00000256
      WBCnstr00000257
      WBCnstr00000259
      WBCnstr00006300
      WBCnstr00010276
      WBCnstr00014688
      WBCnstr00037756
    Microarray_results (19)
    Expression_cluster (184)
    Interaction (11)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
      WBbiopr:00000120
  Map_info: Map: III Position: -2.649 Error: 0.036999
    Well_ordered
    Positive: Positive_clone: F17C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3712
        4625
  Reference (62)
  Remark: Data extracted from Berger et al. (1998)
    Data extracted from Korswagen et al. (1998)
    Sequence connection from [Berger AJ]
    Positive_clone F17C8 is based on cosmid rescue, mutant sequence [Berger AJ, Kaplan JM, Korswagen HC][[030403 ck1]
  Method: Gene