WormBase Tree Display for Gene: WBGene00000877

WBGene00000877 SMap: S_parent: Sequence: Y49A3A
  Identity: Version: 2
    Name: CGC_name: cyn-1 Person_evidence: WBPerson466
      Sequence_name: Y49A3A.5
      Molecular_name: Y49A3A.5
        Y49A3A.5.1
        CE22213
      Other_name: cyp-1 Person_evidence: WBPerson466
        CELE_Y49A3A.5 Accession_evidence: NDB BX284605
      Public_name: cyn-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Sep 2004 16:20:02 WBPerson1971 Name_change: CGC_name: cyp-1 -> cyn-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyn
    Allele (25)
    Legacy_information: [C.elegansII] NMK. Cyclophilin family, transspliced to SL1. Partial sequence identity 83% to human CYP gene, 74% to yeast CSBY. Possible signal peptide. YAC Y14B8[WS, TP]
    RNASeq_FPKM (74)
    GO_annotation: 00047571
      00047572
      00047573
      00047574
      00047575
      00047576
      00047577
      00047578
      00047579
      00047580
      00107924
      00107925
    Ortholog: WBGene00059140 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00027267 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00154966 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00103512 Pristionchus pacificus From_analysis: OMA
      WBGene00130376 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00126756 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00162972 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00135996 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00056729 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00057761 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00053691 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00191549 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00162181 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00064228 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00149830 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00057760 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00157678 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00154586 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00142276 Caenorhabditis brenneri From_analysis: TreeFam
      CSP21.g9430 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g12809 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g2103 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP31.g25816 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g14046 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2028 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g12657 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g19959 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g24320 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g4603 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_01055.g15519 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g20565 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp5_scaffold_00004.g255 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_23478 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_017523 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_50361610 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g16508 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00260945 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285843 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000002562 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      SGD:S000004543 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0004432 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0036415 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-7459 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-8556 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-051030-126 Danio rerio From_analysis: Hieranoid
            OMA
            OrthoInspector
      HGNC:9253 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:9259 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:33996 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:33998 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:24369 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:33995 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:33999 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:33997 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:53889 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      MGI:2145814 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:97749 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:3372 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:628670 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1559682 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      RGD:2321083 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:6493676 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
    Paralog (18)
    Structured_description: Concise_description: cyn-1 encodes a functional cyclophilin that is predicted to be secreted; cyn-1 expression increases as worms progress from the L1 larval stage to the adult stage; cyn-1 shares an operon with vha-13 and thus might be a previously undescribed V-ATPase component or ancillary protein. Paper_evidence: WBPaper00002472
            WBPaper00015191
            WBPaper00018604
            WBPaper00026884
            WBPaper00028773
            WBPaper00028774
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 20 Mar 2007 00:00:00
      Automated_description: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:1474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:12506 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
  Molecular_info: Corresponding_CDS: Y49A3A.5
    Corresponding_transcript: Y49A3A.5.1
    Other_sequence (72)
    Associated_feature: WBsf647527
      WBsf232918
  Experimental_info: RNAi_result: WBRNAi00024337 Inferred_automatically: RNAi_primary
      WBRNAi00024336 Inferred_automatically: RNAi_primary
      WBRNAi00022703 Inferred_automatically: RNAi_primary
      WBRNAi00056993 Inferred_automatically: RNAi_primary
      WBRNAi00027813 Inferred_automatically: RNAi_primary
      WBRNAi00022704 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016338
      Expr1030543
      Expr1160440
      Expr2010669
      Expr2028909
    Microarray_results (19)
    Expression_cluster (160)
    Interaction (73)
  Map_info: Map: V Position: 6.26197 Error: 0.005596
    Positive: Positive_clone: Y14B8 Author_evidence: Page AM
        Y49A3 Author_evidence: Page AM
        Y49A3A Inferred_automatically: From CDS
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: PPIase or cyclophilin, EC 5. 2. 1. 8:
    [Page AM] Isolated independently by M. Hengartner and A. P. Page, Hengartner on library screening, and from mixed stage cDNA by A. P. Page using SL1, and known 3' seq from CEMSW74f.
    [Page AM] No cosmids have been identified (there is a gap in this region). This places this gene in the centre of chromosome V.
    [Page AM] Is transpliced by SL-1
    Partial sequence identity 83% to human CYP gene, 74% to yeast CSBY. Possible signal peptide.
    PPIase or cyclophilin, EC 5.2.1.8
    This gene has been renamed with approval of the CGC (cyp-1->cyn-1) Person_evidence: WBPerson466
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene