WBGene00003052 | SMap | S_parent | Sequence | DY3 |
| Identity | Version | 1 |
| | Name | CGC_name | lmn-1 |
| | | Sequence_name | DY3.2 |
| | | Molecular_name | DY3.2 |
| | | | DY3.2.1 |
| | | | CE15746 |
| | | Other_name | Lam1 | Accession_evidence | EMBL | X74027 |
| | | | CELE_DY3.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | lmn-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lmn |
| | Allele (48) |
| | Strain | WBStrain00026339 |
| | | WBStrain00026341 |
| | | WBStrain00026343 |
| | | WBStrain00040720 |
| | | WBStrain00002790 |
| | | WBStrain00026345 |
| | | WBStrain00034808 |
| | Component_of_genotype | WBGenotype00000131 |
| | | WBGenotype00000150 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00071688 |
| | | 00071689 |
| | | 00071690 |
| | | 00071691 |
| | | 00071692 |
| | | 00071693 |
| | | 00071694 |
| | | 00071695 |
| | | 00071696 |
| | | 00071697 |
| | | 00071698 |
| | | 00071699 |
| | | 00071700 |
| | | 00071701 |
| | | 00071702 |
| | | 00071703 |
| | | 00071704 |
| | | 00071705 |
| | | 00071706 |
| | | 00071707 |
| | | 00071708 |
| | | 00071709 |
| | | 00071710 |
| | | 00071711 |
| | | 00071712 |
| | | 00071713 |
| | | 00071714 |
| | | 00071715 |
| | | 00071716 |
| | | 00071717 |
| | | 00071718 |
| | | 00071719 |
| | | 00071720 |
| | | 00071721 |
| | | 00071722 |
| | | 00071723 |
| | Ortholog | WBGene00060006 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00033322 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00151028 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00128699 | Caenorhabditis japonica | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00223334 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g9223 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g7430 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g10144 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g1596 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g9586 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g7740 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP32.g5538 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP38.g8715 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g6155 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g24248 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00584.g12487 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_08783.g21705 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cni-lmn-1 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold630.g20533 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_01731.g22780 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_05073 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_002532 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g12020 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g23257 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_10124610 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrI_pilon.g1669 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00237498 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00204950 | Pristionchus pacificus | From_analysis | WormBase-Compara |
| | | WBGene00261595 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | | WBGene00262017 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | | WBGene00287782 | Trichuris muris | From_analysis | WormBase-Compara |
| | | WBGene00296617 | Trichuris muris | From_analysis | WormBase-Compara |
| | | WBGene00297750 | Trichuris muris | From_analysis | WormBase-Compara |
| | | WBGene00300747 | Trichuris muris | From_analysis | WormBase-Compara |
| | | FB:FBgn0002525 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | FB:FBgn0010397 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-990630-13 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-020424-3 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-020424-2 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-020424-4 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:6636 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:6637 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:6638 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:96794 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:96795 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:96796 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:620456 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:620522 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:1563803 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | Paralog (12) |
| | Structured_description | Concise_description | lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. | Paper_evidence | WBPaper00004416 |
| | | | | | WBPaper00005158 |
| | | | | | WBPaper00028870 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 24 Feb 2009 00:00:00 |
| | | Automated_description | Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:3911 | Homo sapiens | Paper_evidence | WBPaper00032926 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 24 May 2018 00:00:00 |
| | | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040258 |
| | | | | | WBPaper00038510 |
| | | | | Accession_evidence | OMIM | 181350 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 26 Jul 2023 00:00:00 |
| | | DOID:0050557 | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 04 Feb 2013 00:00:00 |
| | Potential_model | DOID:0111450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) |
| | | DOID:0110156 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0060785 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6637) |
| | | DOID:0111584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070370 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:6713 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6637,HGNC:6638) |
| | | DOID:11712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070202 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0050431 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070247 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0110425 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0050440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070248 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0081128 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0110640 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:5688 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:3911 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:11726 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0080334 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0050820 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:811 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0080299 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) |
| Models_disease_in_annotation | WBDOannot00000297 |
| Models_disease_asserted | WBDOannot00000298 |
| | WBDOannot00000531 |
| | WBDOannot00000541 |
| | WBDOannot00001395 |
| Molecular_info | Corresponding_CDS | DY3.2 |
| | Corresponding_transcript | DY3.2.1 |
| | Other_sequence (14) |
| | Associated_feature (18) |
| Experimental_info | RNAi_result (42) |
| | Expr_pattern (13) |
| | Drives_construct (13) |
| | Construct_product (17) |
| | Regulate_expr_cluster | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00059378:lmn-1(Y59C)_downregulated |
| | | WBPaper00059378:lmn-1(Y59C)_upregulated |
| | Antibody (13) |
| | Microarray_results (23) |
| | Expression_cluster (148) |
| | Interaction (170) |
| Map_info | Map | I | Position | 3.07104 | Error | 0.005882 |
| | Positive | Positive_clone | DY3 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4741 |
| | Pseudo_map_position |
| Reference (67) |
| Remark | Sequence connection based on email from Wen |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |