WormBase Tree Display for Gene: WBGene00018680

WBGene00018680 SMap: S_parent: Sequence: F52C12
  Identity: Version: 2
    Name (5)
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Nov 2014 11:51:19 WBPerson2970 Name_change: CGC_name: tsen-54
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tsen
    Allele (99)
    RNASeq_FPKM (74)
    GO_annotation: 00097285
      00097286
      00097287
      00097288
    Contained_in_operon: CEOP4052
    Ortholog (24)
    Structured_description: Automated_description: Predicted to enable endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Is an ortholog of human TSEN54 (tRNA splicing endonuclease subunit 54). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060274 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27561)
      DOID:0060267 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27561)
      DOID:0060273 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27561)
  Molecular_info: Corresponding_CDS: F52C12.3
    Corresponding_transcript: F52C12.3.1
    Other_sequence: HC08381
    Associated_feature (12)
  Experimental_info: RNAi_result: WBRNAi00062258 Inferred_automatically: RNAi_primary
      WBRNAi00047928 Inferred_automatically: RNAi_primary
      WBRNAi00032588 Inferred_automatically: RNAi_primary
      WBRNAi00110855 Inferred_automatically: RNAi_primary
      WBRNAi00015370 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021893
      Expr1038041
      Expr1151757
      Expr2017535
      Expr2035673
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00048988:daf-2(e1370)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058678:DAF-12_upregulated_PVD
      WBPaper00059194:KLF-1_interacting
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:Neuroblast_AIZ_FLP_RMG
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:PVR
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:trcs-2_5724-R11A8.7_17645
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037147:heatshock_upregulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      [cgc6390]:oogenesis-enriched
  Map_info: Positive: Positive_clone: F52C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: IV -12.7356
  Method: Gene