WormBase Tree Display for Gene: WBGene00017066

WBGene00017066 SMap: S_parent: Sequence: D2092
  Identity: Version: 2
    Name: CGC_name: maco-1 Paper_evidence: WBPaper00038258
          Person_evidence: WBPerson724
      Sequence_name: D2092.5
      Molecular_name: D2092.5
        D2092.5.1
        CE45670
      Other_name: CELE_D2092.5 Accession_evidence: NDB BX284601
      Public_name: maco-1
    DB_info: Database: AceView gene 1H170
        WormQTL gene WBGene00017066
        WormFlux gene WBGene00017066
        NDB locus_tag CELE_D2092.5
        Panther gene CAEEL|WormBase=WBGene00017066|UniProtKB=P91193
          family PTHR13289
        NCBI gene 183963
        RefSeq protein NM_059501.7
        SwissProt UniProtAcc P91193
        TREEFAM TREEFAM_ID TF324023
        UniProt_GCRP UniProtAcc P91193
    Species: Caenorhabditis elegans
    History: Version_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: maco
    Allele (80)
    Strain: WBStrain00033005
      WBStrain00022012
      WBStrain00022013
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (37)
    Structured_description: Concise_description: maco-1 encodes a novel protein with five transmembrane domains in the N-terminus and four coiled coil domains in the C-terminus; maco-1 is functionally conserved across species and is orthologous to human macoilin (OMIM:601301); macoilin is involved in assembly or traffic of ion channels or ion channel regulators; MACO-1 is not required for development but for appropriate regulation of neuronal activity; both transmembrane domains and coiled coil domains are required for appropriate function of MACO-1; proper function of MACO-1 is necessary for normal thermotaxis in many neurons; mutations in C. elegans macoilin disrupt aggregation and are associated with multiple behavioral defects; MACO-1 is localized to the rough ER of neurons; MACO-1 is also restricted to neuronal cell bodies at embryonic developmental stages. Paper_evidence: WBPaper00038258
            WBPaper00038428
          Curator_confirmed: WBPerson12884
          Date_last_updated: 15 Jul 2011 00:00:00
      Automated_description: Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Expressed in epithelial cell; muscle cell; and nervous system. Is an ortholog of human MACO1 (macoilin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: D2092.5
    Corresponding_CDS_history: D2092.5:wp154
      D2092.5:wp221
    Corresponding_transcript: D2092.5.1
    Other_sequence: CRC06233_1
      Oden_isotig19062
      CR10623
      CJC09089_1
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00043519 Inferred_automatically: RNAi_primary
      WBRNAi00043518 Inferred_automatically: RNAi_primary
      WBRNAi00007973 Inferred_automatically: RNAi_primary
      WBRNAi00003295 Inferred_automatically: RNAi_primary
      WBRNAi00116562 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00013794
      WBCnstr00013887
      WBCnstr00013888
      WBCnstr00018769
      WBCnstr00027595
    Construct_product: WBCnstr00013794
      WBCnstr00013888
      WBCnstr00021857
      WBCnstr00027595
    Antibody: WBAntibody00002220
    Microarray_results (20)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059174:PGL-1_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:AIZ
      WBPaper00061340:AUA
      WBPaper00061340:Neuroblast_PVC_LUA
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061527:tag-266-cand-1_14017
      WBPaper00062103:neuron_enriched
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066085:sin-3(tm1276)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00027758:Group_IV
      WBPaper00029437:dcr-1_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00036286:Pattern_F
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00042274:tbx-2(bx59)_downregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc6390]:Cluster_E
    Interaction: WBInteraction000253192
      WBInteraction000303978
      WBInteraction000323592
      WBInteraction000443269
    WBProcess: WBbiopr:00000025
  Map_info: Map: I Position: 1.23755 Error: 0.004358
    Positive: Positive_clone: D2092 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene