WormBase Tree Display for Gene: WBGene00010062

WBGene00010062 SMap: S_parent: Sequence: F54F3
  Identity: Version: 2
    Name: CGC_name: lipl-1 Person_evidence: WBPerson3759
            WBPerson7490
            WBPerson545
      Sequence_name: F54F3.3
      Molecular_name: F54F3.3
        F54F3.3.1
        CE18732
      Other_name: CELE_F54F3.3 Accession_evidence: NDB BX284605
      Public_name: lipl-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 19 Jul 2010 13:43:13 WBPerson2970 Name_change: CGC_name: lipl-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lipl
    Allele (32)
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (73)
    Paralog (8)
    Structured_description: Automated_description: Predicted to enable hydrolase activity, acting on ester bonds. Involved in lipid catabolic process. Located in lysosome. Expressed in intestine. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Is an ortholog of several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:14502 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:14497 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:0060717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23452)
  Molecular_info: Corresponding_CDS: F54F3.3
    Corresponding_transcript: F54F3.3.1
    Other_sequence (158)
    Associated_feature: WBsf647418
      WBsf661943
      WBsf232714
  Experimental_info: RNAi_result (6)
    Expr_pattern: Chronogram1974
      Expr6184
      Expr1016806
      Expr1152165
      Expr2013204
      Expr2031436
    Drives_construct: WBCnstr00003635
      WBCnstr00017676
      WBCnstr00031698
    Construct_product: WBCnstr00031698
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:Cluster_5
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_rde-4
      WBPaper00032425:down_in_zfp-1
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036738:4uM_Heme_downregulated
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00041954:ethanol_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044316:HgCl2_7.5uM_upregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045971:tunicamycin_upregulated_RtcB(null)
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049498:npr-1(ur89)_regulated_5
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00051137:N.parisii-virus_upregulated_N2
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051540:exc-7(csb29);mbl-1(csb30)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:OrsayVirus-infection_upregulated
      WBPaper00053020:sid-3(ok973)_downregulated
      WBPaper00053020:sta-1(ok587)_downregulated
      WBPaper00053092:procyanidins_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053368:F.oxysporum_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:25C_upregulated_PY79
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055941:hif-1(ia4)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056165:mina-1(ok1521)_downregulated_transcript
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056446:hsb-1(cg116)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_upregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057254:MWCNT_downregulated_mRNA
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_downregulated_N2
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060273:isp-1(qm150)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060634:unc-120(st364)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:M.braciatum_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:asah-1-asm-2
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062446:nhr-8(ok186)_upregulated
      WBPaper00062534:fat-P-80_upregulated
      WBPaper00062534:fat-P-80_upregulated_ech-6(RNAi)
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062672:dcp-66(RNAi)_downregulated
      WBPaper00062672:let-418(n3536)_upregulated
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_upregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065086:JU1400_N.parisii_regulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065086:N2_N.ironsii_regulated
      WBPaper00065086:N2_N.parisii_regulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_20C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:25C_vs_15C_downregulated_AFD
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065331:100nM-ivermectin_downregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065581:hpk-1(pk1393)_downregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      WBPaper00065877:rege-1(imm070)_upregulated_PA14
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027722:Microbacterium_nematophilum_upregulated
      WBPaper00028789:PA14_vs_gacA_upregulated_8hr
      WBPaper00031703:heme_responsive_4
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:A_to_C_transit_decreased
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00032948:StarveUp3
      WBPaper00033101:spr-5_regulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035892:KIM5_vs_OP50_Up
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00038462:aging_downregulated
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040184:hcf-1nc_sir-2.1up_daf-2up
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
      WBPaper00040808:1.1uM_ivermectin_upregulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_0.2mM_Down
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.aureus_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041609:hpl-1_hpl-2_downregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042258:HT115_upregulated_YoungAdult
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00044535:male_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_upregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00050650:mBmkTX_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053688:E.faecium_downregulated
      WBPaper00056391:HT115_upregulated
    Interaction (36)
  Map_info: Map: V Position: 4.73223 Error: 0.002129
    Positive: Positive_clone: F54F3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene