WormBase Tree Display for Gene: WBGene00009939

WBGene00009939 SMap: S_parent: Sequence: F52F12
  Identity: Version: 4
    Name: CGC_name: ztf-11 Person_evidence: WBPerson524
            WBPerson1997
      Sequence_name: F52F12.6
      Molecular_name: F52F12.6a
        F52F12.6a.1
        CE24995
        F52F12.6b
        CE46793
        F52F12.6b.1
      Other_name: ekl-2 Paper_evidence: WBPaper00031487
        CELE_F52F12.6 Accession_evidence: NDB BX284601
      Public_name: ztf-11
    DB_info: Database: AceView gene 1K482
        WormQTL gene WBGene00009939
        WormFlux gene WBGene00009939
        NDB locus_tag CELE_F52F12.6
        NCBI gene 172845
        RefSeq protein NM_001264316.3
            NM_001264317.3
        SwissProt UniProtAcc O02274
        TREEFAM TREEFAM_ID TF317299
        UniProt_GCRP UniProtAcc O02274
        OMIM gene 613084
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 18 Jul 2005 13:34:00 WBPerson2970 Name_change: CGC_name: ekl-2
        3 22 Oct 2007 15:16:41 WBPerson2970 Name_change: CGC_name: ztf-11
        4 20 Feb 2008 16:59:39 WBPerson2970 Name_change: Other_name: ztf-11
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ztf
    Allele (70)
    Strain: WBStrain00031537
      WBStrain00030095
      WBStrain00030097
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (40)
    Paralog: WBGene00010867 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable zinc ion binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neuron differentiation; and positive regulation of cell differentiation. Located in nucleus. Expressed in g1 and head neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Is an ortholog of human MYT1L (myelin transcription factor 1 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070069 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7623)
  Molecular_info: Corresponding_CDS: F52F12.6a
      F52F12.6b
    Corresponding_transcript: F52F12.6a.1
      F52F12.6b.1
    Other_sequence: JI169553.1
      Dviv_isotig18198
      Dviv_isotig18199
    Associated_feature (17)
    Gene_product_binds (297)
    Transcription_factor: WBTranscriptionFactor000759
  Experimental_info: RNAi_result: WBRNAi00082504 Inferred_automatically: RNAi_primary
      WBRNAi00003743 Inferred_automatically: RNAi_primary
      WBRNAi00116763 Inferred_automatically: RNAi_primary
      WBRNAi00000286 Inferred_automatically: RNAi_primary
      WBRNAi00048012 Inferred_automatically: RNAi_primary
      WBRNAi00070207 Inferred_automatically: RNAi_primary
      WBRNAi00082618 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr427
      Expr1020528
      Expr1034330
      Expr1151827
      Expr1200080
      Expr1200081
      Expr2018185
      Expr2036322
    Drives_construct: WBCnstr00037854
    Construct_product: WBCnstr00016725
      WBCnstr00018914
      WBCnstr00037854
    Regulate_expr_cluster: WBPaper00057143:ztf-11(RNAi)_downregulated
      WBPaper00057143:ztf-11(RNAi)_upregulated
    Microarray_results (20)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045521:Oogenic
      WBPaper00045618:puf-8_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048690:gonad-male-biased
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049954:BPS_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051437:Cit-SPIONs_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055334:DLC-1_interacting
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056619:CEPsh_enriched
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00059728:5ug_cholesterol_downregulated
      WBPaper00059728:20ug_cholesterol_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:ADL_parent
      WBPaper00061340:ALA
      WBPaper00061340:ASE_parent
      WBPaper00061340:AVH_parent
      WBPaper00061340:AVL
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:DVC_parent
      WBPaper00061340:g1A_g1P
      WBPaper00061340:g1A_parent
      WBPaper00061340:g2
      WBPaper00061340:g2_parent
      WBPaper00061340:I1_parent
      WBPaper00061340:I2_grandparent
      WBPaper00061340:M1_parent
      WBPaper00061340:M4_parent
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_AIZ_FLP
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_ASG_AWA
      WBPaper00061340:Neuroblast_ASH_RIB
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:OLQ_grandparent
      WBPaper00061340:Parent_of_exc_gland_AVK
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:PVQ_parent
      WBPaper00061340:RIM_parent
      WBPaper00061340:RME_LR_parent
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_downregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:utx-1_2886-swan-1_2192
      WBPaper00061651:HSN_enriched
      WBPaper00061651:VC_4_5_enriched
      WBPaper00062146:MOG-7-degron_2h_regulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_transcript
      WBPaper00062456:doxycycline_downregulated_N2_transcript
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:17_0
      WBPaper00065841:19_0
      WBPaper00065841:50_0
      WBPaper00065841:59_0
      WBPaper00065841:68_0
      WBPaper00065841:68_1
      WBPaper00065841:70_0
      WBPaper00065841:80_0
      WBPaper00065841:95_0
      WBPaper00065841:96_0
      WBPaper00065841:106_0
      WBPaper00065841:117_0
      WBPaper00065841:123_0
      WBPaper00065841:125_0
      WBPaper00065841:135_0
      WBPaper00065841:139_0
      WBPaper00065841:140_0
      WBPaper00065841:145_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_6_4
      cgc4489_group_12
      WBPaper00025032:cluster_126
      WBPaper00025032:cluster_169
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037695:WC_5-day
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:cluster_73
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(53_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
    Interaction (40)
  Map_info: Map: I Position: 4.05133 Error: 0.011125
    Positive: Positive_clone: F52F12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5407
        5060
    Pseudo_map_position
  Reference (8)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene