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WormBase Tree Display for Gene: WBGene00007135

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Name Class

WBGene00007135SMapS_parentSequenceB0285
IdentityVersion4
NameCGC_namecdk-12Person_evidenceWBPerson313
WBPerson3232
WBPerson555
Sequence_nameB0285.1
Molecular_name (12)
Other_namecdtl-7Person_evidenceWBPerson3232
WBPerson555
CELE_B0285.1Accession_evidenceNDBBX284603
Public_namecdk-12
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:47WBPerson1971EventImportedInitial conversion from CDS class of WS125
202 Mar 2009 11:15:07WBPerson9133Name_changeCGC_namecdtl-7
323 Nov 2012 14:00:52WBPerson2970Name_changeCGC_namecdk-12
410 Jun 2014 12:12:12WBPerson1983EventAcquires_mergeWBGene00043080
Acquires_mergeWBGene00043080
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcdk
Allele (122)
StrainWBStrain00003574
WBStrain00024046
WBStrain00024054
WBStrain00024069
WBStrain00024070
WBStrain00037602
RNASeq_FPKM (74)
GO_annotation (24)
Ortholog (38)
Paralog (17)
Structured_descriptionAutomated_descriptionPredicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in nematode larval development. Part of euchromatin. Expressed in several structures, including germ line and head. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; carcinoma (multiple); and congenital heart defects, dysmorphic facial features, and intellectual developmental disorder. Is an ortholog of human CDK13 (cyclin dependent kinase 13).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0112247Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1733)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:24224)
DOID:10286Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1733)
DOID:3717Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:24224)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1733)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1733,HGNC:24224)
DOID:1059Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1733)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1733)
Molecular_infoCorresponding_CDSB0285.1a
B0285.1b
B0285.1c
Corresponding_CDS_historyB0285.1:wp23
B0285.1:wp83
Corresponding_transcriptB0285.1a.1
B0285.1a.2
B0285.1b.1
B0285.1b.2
B0285.1c.1
B0285.1c.2
Other_sequence (19)
Associated_feature (11)
Experimental_infoRNAi_result (56)
Expr_patternChronogram501
Expr5038
Expr11660
Expr1020850
Expr1033070
Expr1143059
Expr2009808
Expr2028049
Drives_construct (2)
Construct_productWBCnstr00019156
WBCnstr00019285
WBCnstr00019286
WBCnstr00019287
WBCnstr00033974
Microarray_results (26)
Expression_clusterWBPaper00032425:up_in_zfp-1
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00044037:eat-2_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048988:neuron_expressed
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050990:body-muscle_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00053814:25C_downregulated_PY79
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056826:SGP_biased
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059334:SACY-1_interacting
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061340:Parent_of_K_Kprime
WBPaper00061527:mtr-4_1623-W03F9.10_103
WBPaper00061527:Y32B12B.2-F28C1.1
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00063930:BRD-1_interacting
WBPaper00064071:NHR-49_interacting
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
cgc4489_group_2
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031832:slr-2_regulated
WBPaper00032062:age_regulated_genes
WBPaper00032948:FedUp
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_H
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040821:Au-NP_regulated
WBPaper00041002:HF_11d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041174:environmental
WBPaper00041174:environmental_prime
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00048989:N2_allantoin_downregulated
WBPaper00053236:Starvation_regulated_N2
[cgc6390]:mixed_oogenesis-somatic
Interaction (92)
Map_infoMapIIIPosition-3.18675Error0.000933
PositivePositive_cloneB0285Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027258
WBPaper00031224
WBPaper00032961
WBPaper00038491
WBPaper00044000
WBPaper00047409
WBPaper00055090
WBPaper00060756
WBPaper00063946
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
[140610 pad] Gene was missing Acquires_merge Event history data so inferred from Acquires_merge tag.
MethodGene