Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006721

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006721EvidencePerson_evidenceWBPerson2549
WBPerson6733
SMapS_parentSequenceF46E10
IdentityVersion1
NameCGC_nameubh-1
Sequence_nameF46E10.8
Molecular_nameF46E10.8
F46E10.8.1
CE20818
Other_nameF46E10.fCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_F46E10.8Accession_evidenceNDBBX284605
Public_nameubh-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classubh
Allele (25)
RNASeq_FPKM (74)
GO_annotation (21)
Contained_in_operonCEOP5120
Ortholog (39)
Paralog (3)
Structured_descriptionConcise_descriptionubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence.Paper_evidenceWBPaper00027616
WBPaper00035660
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated15 Jul 2013 00:00:00
Automated_descriptionEnables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development; positive regulation of transforming growth factor beta receptor signaling pathway; and protein deneddylation. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14330Homo sapiensPaper_evidenceWBPaper00035660
Accession_evidenceOMIM613643
Curator_confirmedWBPerson324
Date_last_updated15 Jul 2013 00:00:00
Potential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:0070455Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:14330Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:0112344Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
Disease_relevanceMutations in human ubiquitin C-terminal hydrolase L1 (UCHL1/PARK5; neuron specific) are associated with Parkinson''s disease (PD); UCH-L1 protects against protein aggregation disorders such as Alzheimer disease and PD and is part of the ubiquitin proteasome system; C. elegans is used as a model system to study the genetic interactions and molecular functions of PARK protein orthologs; studies that knock-down the ubh genes in elegans (ubh-1, ubh-2, ubh-3) indicate that they are involved in cellular senescence and thus aging.Homo sapiensPaper_evidenceWBPaper00027616
WBPaper00035660
Accession_evidenceOMIM613643
191342
Curator_confirmedWBPerson324
Date_last_updated15 Jul 2013 00:00:00
Models_disease_in_annotationWBDOannot00000209
Molecular_infoCorresponding_CDSF46E10.8
Corresponding_transcriptF46E10.8.1
Other_sequence (36)
Associated_featureWBsf669046
WBsf669047
WBsf669048
WBsf1000286
WBsf233815
Experimental_infoRNAi_resultWBRNAi00102982Inferred_automaticallyRNAi_primary
WBRNAi00102992Inferred_automaticallyRNAi_primary
WBRNAi00102972Inferred_automaticallyRNAi_primary
WBRNAi00015095Inferred_automaticallyRNAi_primary
WBRNAi00056335Inferred_automaticallyRNAi_primary
WBRNAi00094630Inferred_automaticallyRNAi_primary
WBRNAi00047527Inferred_automaticallyRNAi_primary
WBRNAi00076438Inferred_automaticallyRNAi_primary
Expr_patternExpr15525
Expr1027646
Expr1151366
Expr2017718
Expr2035856
Drives_constructWBCnstr00042221
Construct_productWBCnstr00042221
Microarray_results (17)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_SelectivelyEnriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045729:gld-2(RNAi)_upregulated
WBPaper00045934:wrn-1(gk99)_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00056169:rrf-3(pk1426)_upregulated_L2
WBPaper00056619:CEPsh_enriched
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00059763:neuron_expressed
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061340:AIN
WBPaper00061340:ALA
WBPaper00061340:ASI
WBPaper00061340:AVA
WBPaper00061340:AVB
WBPaper00061340:AVD
WBPaper00061340:AVG
WBPaper00061340:AVH
WBPaper00061340:AVJ
WBPaper00061340:AVK
WBPaper00061340:AVL
WBPaper00061340:DVA
WBPaper00061340:DVC
WBPaper00061340:FLP
WBPaper00061340:PVP
WBPaper00061340:PVT
WBPaper00061340:RID
WBPaper00061340:RIM
WBPaper00061340:RIS
WBPaper00061340:SIA
WBPaper00061340:URA_parent
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061527:cids-2_2203-attf-2_2451
WBPaper00061651:ALA_enriched
WBPaper00061651:AMso_enriched
WBPaper00061651:AVF_enriched
WBPaper00061651:AVG_enriched
WBPaper00061651:AVJ_enriched
WBPaper00061651:AVL_enriched
WBPaper00061651:AVM_enriched
WBPaper00061651:DB01_enriched
WBPaper00061651:DB_enriched
WBPaper00061651:DVA_enriched
WBPaper00061651:DVB_enriched
WBPaper00061651:DVC_enriched
WBPaper00061651:FLP_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:PDA_enriched
WBPaper00061651:PVC_enriched
WBPaper00061651:PVM_enriched
WBPaper00061651:PVP_enriched
WBPaper00061651:PVQ_enriched
WBPaper00061651:PVR_enriched
WBPaper00061651:PVT_enriched
WBPaper00061651:PVW_enriched
WBPaper00061651:RID_enriched
WBPaper00061651:SMB_enriched
WBPaper00061651:VC_4_5_enriched
WBPaper00061651:VC_enriched
WBPaper00062103:neuron_enriched
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064716:paraquat_upregulated
WBPaper00064992:Capsaicin_downregulated
WBPaper00065258:anchor-cell_enriched
WBPaper00065623:154
WBPaper00065841:50_0
WBPaper00065841:51_0
WBPaper00065841:51_1
WBPaper00065841:68_1
WBPaper00065841:103_0
WBPaper00065841:114_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065993:glp-1(e2141)_downregulated
cgc4489_group_8
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032948:FedUp
WBPaper00034739:N2lessDR1350
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036123:Cadmium_regulated
WBPaper00036286:Pattern_H
WBPaper00037695:WC_5-day
WBPaper00041002:HF_11d_2.0mM_Up
WBPaper00041002:HQ_3d_0.2mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00047070:N2_starvation_downregulated
Interaction (17)
Map_infoMapVPosition-0.032234Error0.006589
PositivePositive_cloneF46E10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00010020
WBPaper00025802
WBPaper00027616
WBPaper00030133
WBPaper00030965
WBPaper00038491
WBPaper00055090
WBPaper00060977
WBPaper00063803
WBPaper00064934
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene