| WBGene00004737 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F10G7 |
| Identity | Version | 1 |
| | Name | CGC_name | scc-1 | Person_evidence | WBPerson421 |
| | | Sequence_name | F10G7.4 |
| | | Molecular_name | F10G7.4 |
| | | | F10G7.4.1 |
| | | | CE02628 |
| | | Other_name | coh-2 | Person_evidence | WBPerson421 |
| | | | | | WBPerson1819 |
| | | | rad-21.1 |
| | | | CELE_F10G7.4 | Accession_evidence | NDB | BX284602 |
| | | Public_name | scc-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | scc |
| | Allele (26) |
| | Legacy_information | [J. Loidl] RNAi phenotypes : ~98% embryo lethality, HIM (~3% males); protein localizes to somatic nuclei of the embryo and to nuclei at meiotic prophase |
| | | [J. Loidl] (F10G7.4) is homolog to the Rad21/Scc1/Rec8 family of cohesion proteins with knownmembers in S. cerevisiae, S. pombe, A. thaliana and vertebrates. R-S-R is the acronym of the founder family. |
| | Strain | WBStrain00035987 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (44) |
| | Paralog | WBGene00000591 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. | Paper_evidence | WBPaper00004651 |
| | | | | | WBPaper00004722 |
| | | | | | WBPaper00005039 |
| | | | | | WBPaper00018377 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in meiotic cell cycle. Located in nucleus. Part of cohesin complex. Expressed in several structures, including SDQ; germ line; seam cell; touch receptor neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0080508 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) |
| | | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) |
| | | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) |
| | | DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) |
| | | DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) |
| Molecular_info | Corresponding_CDS | F10G7.4 |
| | Corresponding_transcript | F10G7.4.1 |
| | Other_sequence | CRC06495_1 |
| | | MP00107 |
| | | BXC03089_1 |
| | | CBC02363_1 |
| | | MI06164 |
| | | CJC04977_1 |
| | | CR03754 |
| | | RSC00091_1 |
| | | CJC01832_1 |
| | | MIC05797_1 |
| | Associated_feature (3) |
| Experimental_info | RNAi_result (17) |
| | Expr_pattern | Expr1350 |
| | | Expr2579 |
| | | Expr11962 |
| | | Expr1015315 |
| | | Expr1032337 |
| | | Expr1148255 |
| | | Expr2015621 |
| | | Expr2033856 |
| | Drives_construct | WBCnstr00035420 |
| | Construct_product | WBCnstr00035420 |
| | Antibody | WBAntibody00000375 |
| | | WBAntibody00000636 |
| | | WBAntibody00000645 |
| | | WBAntibody00000646 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00042194:nhr-114(RNAi)_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045050:csr-1(hypomorph)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045934:wrn-1(gk99)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048690:male-Z1-Z4-daughter_enriched |
| | | WBPaper00048762:FOG-1_associated |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_8 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050193:cec-4(ok3124)_downregulated_L1 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_downregulated_smallRNA |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:DVC_parent |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061340:RME_LR_parent |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:F54E7.8-orc-5_6376 |
| | | WBPaper00061699:daf-18(ok480)_upregulated |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061902:CAMT-1_interacting |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_7 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_13 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:intrinsic |
| | Interaction (107) |
| | WBProcess | WBbiopr:00000099 |
| Map_info | Map | II | Position | -3.59162 | Error | 0.111344 |
| | Positive | Positive_clone | F10G7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4996 |
| | Pseudo_map_position |
| Reference (13) |
| Remark | Sequence connection from [Sugimoto A] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
