WormBase Tree Display for Gene: WBGene00004358

WBGene00004358 SMap: S_parent: Sequence: F08F3
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: rhr
    Allele (35)
    Legacy_information: [Nettell J] rhr for Rh blood group antigen related. No mutants known. Predicted gene F08F3.3
    Strain: WBStrain00003312
      WBStrain00030768
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (52)
    Paralog: WBGene00000133 Caenorhabditis elegans From_analysis: Panther
      WBGene00000134 Caenorhabditis elegans From_analysis: Panther
      WBGene00000135 Caenorhabditis elegans From_analysis: Panther
      WBGene00000136 Caenorhabditis elegans From_analysis: Panther
      WBGene00004359 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: rhr-1 encodes an ortholog of human Rhesus blood-group associated glycoprotein (RHAG; OMIM:180297, mutated in chronic hemolytic anemia), a member of the ammonium transporter family, and affects general levels of mRNA transcripts, and embryonic viability in a large-scale RNAi screen. Paper_evidence: WBPaper00004651
            WBPaper00019491
          Curator_confirmed: WBPerson48
            WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables ammonium transmembrane transporter activity. Involved in ammonium transmembrane transport. Predicted to be located in plasma membrane. Expressed in head. Human ortholog(s) of this gene implicated in Rh deficiency syndrome; Rh isoimmunization; and overhydrated hereditary stomatocytosis. Is an ortholog of human RHAG (Rh associated glycoprotein); RHBG (Rh family B glycoprotein); and RHCG (Rh family C glycoprotein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050641 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10006)
      DOID:4175 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10009)
      DOID:0111562 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10006)
      DOID:583 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10006)
  Molecular_info (4)
  Experimental_info: RNAi_result: WBRNAi00030654 Inferred_automatically: RNAi_primary
      WBRNAi00077594 Inferred_automatically: RNAi_primary
      WBRNAi00002398 Inferred_automatically: RNAi_primary
      WBRNAi00044017 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram125
      Expr3969
      Expr5683
      Expr5684
      Expr1017093
      Expr1032175
      Expr1147985
      Expr2015339
      Expr2033573
    Drives_construct: WBCnstr00002746
      WBCnstr00003783
      WBCnstr00035541
    Construct_product: WBCnstr00035541
    Microarray_results (22)
    Expression_cluster: WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1291
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00036738:500uM_Heme_upregulated
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040990:PA14_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00051388:Glucose-diet_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056169:rrf-3(pk1426)_upregulated_L3
      WBPaper00056218:daf-16(mu86)_upregulated_Day3
      WBPaper00056284:ints-6(t1903)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1(gv6)_upregulated_L4_protein
      WBPaper00056617:adr-2(gv42)_upregulated_L4_protein
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00059253:stearic-acid_downregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059529:nonu-1(srf0780)_upregulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059895:wounding_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:AMso
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:C18B2.5-haf-4_181
      WBPaper00061651:PHsh_enriched
      WBPaper00061651:PHso_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_protein
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065392:Lb.gasseri_upregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:0_0
      WBPaper00065841:34_0
      WBPaper00065841:34_1
      WBPaper00065841:64_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_upregulated_N2
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      cgc4386_cluster_1_3
      cgc4489_group_1
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_85
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_F
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031703:heme_responsive_7
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:LD_3-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_20
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:herm_soma-enriched
    Interaction (35)
  Map_info: Map: V Position: -2.02048 Error: 0.028616
    Positive: Positive_clone: F08F3 Author_evidence: Nettell JJ
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5216
        4182
        4348
    Pseudo_map_position
  Reference: WBPaper00004651
    WBPaper00019491
    WBPaper00027209
    WBPaper00032929
    WBPaper00038491
    WBPaper00041771
    WBPaper00046515
    WBPaper00049246
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene