WormBase Tree Display for Gene: WBGene00003553

WBGene00003553 Evidence: Author_evidence: Moehrlen F
  SMap: S_parent: Sequence: C17G1
  Identity: Version: 1
    Name: CGC_name: nas-37 Person_evidence: WBPerson1103
      Sequence_name: C17G1.6
      Molecular_name: C17G1.6a
        C17G1.6a.1
        CE31417
        C17G1.6b
        CE38034
        C17G1.6b.1
      Other_name: CELE_C17G1.6 Accession_evidence: NDB BX284606
      Public_name: nas-37
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nas
    Allele (69)
    Strain: WBStrain00002602
      WBStrain00037444
      WBStrain00006660
      WBStrain00006680
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (31)
    Paralog (48)
    Structured_description: Concise_description: nas-37 encodes a Astacin-class metalloprotease required for full ecdysisthat is expressed in hypodermal cells 4 hours before each ecdysis; NAS-37protein has an N-terminal signal sequence followed by an Astacin proteasedomain and three protein-binding domains (EGF-like, CUB, andthrombospondin); NAS-37 accumulates in anterior cuticle, being shed withit after ecdysis; nas-37 mutants fail to complete anterior ecdysis at eachmolt; nas-37(ox196) mutations alter an evolutionarily invariant histidineresidue yet are phenotypically indistinguishable from null mutations,consistent with the hypothesis that NAS-37 encodes a functional protease;NAS-37 orthologs are found in other nematodes such as Brugia malayi. Paper_evidence: WBPaper00024579
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 16 Dec 2010 00:00:00
      Automated_description: Enables metalloendopeptidase activity. Involved in collagen and cuticulin-based cuticle development and ecdysis, collagen and cuticulin-based cuticle. Located in extracellular region. Expressed in cuticle; epithelial cell; intestine; and rectal gland cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C17G1.6a
      C17G1.6b
    Corresponding_CDS_history: C17G1.6:wp83
    Corresponding_transcript: C17G1.6a.1
      C17G1.6b.1
    Other_sequence (12)
    Associated_feature: WBsf1006575
      WBsf1006576
      WBsf1006577
      WBsf1023644
      WBsf237814
  Experimental_info: RNAi_result (11)
    Expr_pattern (11)
    Drives_construct (11)
    Construct_product (5)
    Microarray_results (22)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045017:blmp-1(tm548)_downregulated
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046024:sleep_downregulated_oscillating
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_expressed
      WBPaper00049954:BPA_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050801:SET-4_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055648:vulva-uterus_expressed
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055969:electromagnetic-field_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_L1
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058927:high-redox-state_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:RID_parent
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:sqt-2-dpy-9
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064532:pals-25(icb98)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064952:Day10_vs_Day1_upregulated_20C
      WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:30_2
      WBPaper00065841:79_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_7
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:Resveratrol_regulated_N2
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_E
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00034739:N2lessDR1350
      WBPaper00034739:RIL17lessRIL14
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00055899:nitroguanidine_regulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc6390]:Cluster_B
      [cgc6390]:herm_sex-enriched
    Interaction (15)
  Map_info: Map: X Position: 1.73123 Error: 0.000121
    Positive: Positive_clone: C17G1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5083
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene