| WBGene00003112 | SMap | S_parent | Sequence | F35G12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mab-21 | Person_evidence | WBPerson261 |
| | | Sequence_name | F35G12.6 |
| | | Molecular_name | F35G12.6 |
| | | | F35G12.6.1 |
| | | | CE32651 |
| | | Other_name | CELE_F35G12.6 | Accession_evidence | NDB | BX284603 |
| | | Public_name | mab-21 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mab |
| | Allele (30) |
| | Legacy_information | [Chow KL] Transformation of thick ray 6 to a thin ray, which is anteriorly displaced and fuses with ray 4 (>95%). A tenth ray derived from hypodermal cell T.apapa is found in about 50% of the sides scored in all three alleles. mab-21(bx53)/yDf10 is embryonic lethal. Both males and hermaphrodites have slightly shorter body length (~85% of wild type) |
| | | [C.elegansII] bx53 : transformation of thick ray 6 to a thin ray, which is anteriorly displaced and fuses with ray 4 (>95%). Tenth ray derived from T.apapa, between rays 5 and 7, is found in ~50% of sides scored. Both males and hermaphrodites have slightly shorter body length (~85% of wild type); reduced brood size; males backward Unc, reduced mating efficiency. Mosaic focus cell autonomous for R6, non-autonomous for T.apapa. Probable hypomorph, bx53/Df is embryonic lethal. OA2: bx41, sy155 (similar). Cloned: encodes predicted 386 aa novel protein. [Baird et al. 1991; Chow et al. 1995; KC; EM; PS] |
| | Complementation_data | [Chow KL] complements emb-1(hc57), emb-2(hc58), emb-5(hc61), emb-7(hc66), emb-8(hc69), emb-13(g6), emb-32(g58) |
| | Strain | WBStrain00002152 |
| | | WBStrain00030819 |
| | | WBStrain00007160 |
| | | WBStrain00007166 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00066952 |
| | | 00066953 |
| | | 00066954 |
| | | 00066955 |
| | Ortholog (38) |
| | Structured_description | Concise_description | mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. | Paper_evidence | WBPaper00002335 |
| | | | | | WBPaper00004801 |
| | | | | | WBPaper00013240 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Involved in cell fate commitment; embryo development; and nematode male tail mating organ morphogenesis. Expressed in several structures, including PVC; VA2; hyp7 syncytium; ray 6; and sensory neurons. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Is an ortholog of human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0111802 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6758) |
| | | DOID:12270 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6758) |
| Molecular_info | Corresponding_CDS | F35G12.6 |
| | Corresponding_transcript | F35G12.6.1 |
| | Other_sequence (37) |
| | Associated_feature | WBsf645104 |
| | | WBsf645105 |
| | | WBsf224765 |
| Experimental_info | RNAi_result (26) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00002911 |
| | | WBCnstr00004455 |
| | | WBCnstr00010357 |
| | | WBCnstr00012531 |
| | | WBCnstr00021618 |
| | | WBCnstr00036224 |
| | Construct_product | WBCnstr00010357 |
| | | WBCnstr00021618 |
| | | WBCnstr00036224 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00029359_1280 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046024:sleep_downregulated_oscillating |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L4 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:hyp7_AB_lineage |
| | | WBPaper00061340:hyp7_C_lineage |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061340:SMB |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:pie-1(ne4433)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:mlt-9_22518-F33D4.6_14044 |
| | | WBPaper00061651:AIA_enriched |
| | | WBPaper00061651:AIB_enriched |
| | | WBPaper00061651:ALM_enriched |
| | | WBPaper00061651:AQR_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:MI_enriched |
| | | WBPaper00061651:PQR_enriched |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061651:RME_LR_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:39_2 |
| | | WBPaper00065841:39_3 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065841:54_0 |
| | | WBPaper00065841:59_0 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:104_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_8 |
| | | WBPaper00025032:cluster_50 |
| | | WBPaper00025032:PAL-1_target_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00038172:crh-1null_up_regulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated |
| | | WBPaper00053827:pyoverdine_upregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc5767]:cluster_12 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(186_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MDE |
| | | [cgc5767]:expression_class_MD_pd(66_min) |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_B |
| | Interaction (17) |
| Map_info | Map | III | Position | -3.02765 | Error | 0.006765 |
| | Well_ordered |
| | Positive | Positive_clone | C56A8 |
| | | | F35G12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Negative_clone | F10F2 |
| | | | W03D1 |
| | Mapping_data (3) |
| Reference (55) |
| Method | Gene |
