| WBGene00003020 | SMap | S_parent | Sequence | C32F10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lin-35 | Person_evidence | WBPerson261 |
| | | Sequence_name | C32F10.2 |
| | | Molecular_name | C32F10.2 |
| | | | C32F10.2.1 |
| | | | CE24823 |
| | | Other_name | CELE_C32F10.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | lin-35 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Allele (104) |
| | Legacy_information | n745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)). |
| | | See also n373, n745 |
| | | [C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS] |
| | Strain (17) |
| | Component_of_genotype | WBGenotype00000009 |
| | RNASeq_FPKM (74) |
| | GO_annotation (50) |
| | Ortholog (43) |
| | Structured_description (2) |
| Disease_info | Experimental_model | DOID:1059 | Homo sapiens | Paper_evidence | WBPaper00024322 |
| | | | | Accession_evidence | OMIM | 309580 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Apr 2013 00:00:00 |
| | Potential_model (16) |
| | Disease_relevance | Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. | Homo sapiens | Paper_evidence | WBPaper00024322 |
| | | | | | WBPaper00024692 |
| | | | | | WBPaper00003646 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 23 Apr 2013 00:00:00 |
| Models_disease_asserted | WBDOannot00000614 |
| | WBDOannot00001021 |
| Molecular_info | Corresponding_CDS | C32F10.2 |
| | Corresponding_transcript | C32F10.2.1 |
| | Associated_feature | WBsf643315 |
| | | WBsf643316 |
| | | WBsf656335 |
| | | WBsf656336 |
| | | WBsf656337 |
| | | WBsf656338 |
| | | WBsf983774 |
| | | WBsf217712 |
| | Gene_product_binds (376) |
| | Transcription_factor | WBTranscriptionFactor000270 |
| Experimental_info | RNAi_result (78) |
| | Expr_pattern | Chronogram622 |
| | | Expr1291 |
| | | Expr3128 |
| | | Expr1015789 |
| | | Expr1031411 |
| | | Expr1145718 |
| | | Expr2013177 |
| | | Expr2031409 |
| | Drives_construct | WBCnstr00004066 |
| | | WBCnstr00006281 |
| | | WBCnstr00011156 |
| | | WBCnstr00017294 |
| | | WBCnstr00036281 |
| | Construct_product | WBCnstr00006281 |
| | | WBCnstr00011156 |
| | | WBCnstr00017287 |
| | | WBCnstr00017294 |
| | | WBCnstr00017295 |
| | | WBCnstr00017296 |
| | | WBCnstr00021077 |
| | | WBCnstr00021078 |
| | | WBCnstr00021079 |
| | | WBCnstr00036281 |
| | Regulate_expr_cluster (16) |
| | Antibody | WBAntibody00000200 |
| | | WBAntibody00001176 |
| | | WBAntibody00003008 |
| | | WBAntibody00003009 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:down_in_lin-35 |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060886:spr-5(by101)_upregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:Ciliated_amphid_neuron |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:Excretory_cell_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:Neuroblast_AIZ_FLP_RMG |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:cyy-1_3136-hcf-1_2478 |
| | | WBPaper00061527:npp-6-mtr-4_21425 |
| | | WBPaper00062056:dpl-1(n2994)_upregulated |
| | | WBPaper00062056:efl-1(se1)_upregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(n766)_upregulated |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062056:lin-37(n758)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_1 |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_197 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_26 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (322) |
| | Product_binds_matrix | WBPmat00005534 |
| | | WBPmat00005535 |
| | | WBPmat00005536 |
| | | WBPmat00005540 |
| | | WBPmat00005541 |
| | | WBPmat00005542 |
| | | WBPmat00005543 |
| | | WBPmat00005544 |
| | | WBPmat00005545 |
| Map_info | Map | I | Position | 0.461719 | Error | 0.000997 |
| | Well_ordered |
| | Positive | Positive_clone | C32F10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 283 |
| | | | 308 |
| | | | 309 |
| | | | 4517 |
| Reference (253) |
| Picture | WBPicture0000013091 |
| Method | Gene |
