WormBase Tree Display for Gene: WBGene00002206

WBGene00002206 SMap: S_parent: Sequence: K07F5
  Identity: Version: 1
    Name: CGC_name: kin-24
      Sequence_name: K07F5.4
      Molecular_name: K07F5.4
        K07F5.4.1
        CE44912
      Other_name: CELE_K07F5.4 Accession_evidence: NDB BX284604
      Public_name: kin-24
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kin
    Allele (38)
    Strain: WBStrain00047546
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (65)
    Paralog (59)
    Structured_description: Automated_description: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3657)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3657)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3657)
  Molecular_info: Corresponding_CDS: K07F5.4
    Corresponding_CDS_history: K07F5.4a:wp214
      K07F5.4b:wp214
    Corresponding_transcript: K07F5.4.1
    Other_sequence (17)
    Associated_feature: WBsf1018007
  Experimental_info: RNAi_result (3)
    Expr_pattern: Expr1023180
      Expr1153885
      Expr2012935
      Expr2031167
    Drives_construct: WBCnstr00036387
    Construct_product: WBCnstr00036387
    Microarray_results (20)
    Expression_cluster: WBPaper00031070:rrf-3_eri-1_upregulated
      WBPaper00032479:CB4856vsN2_LifeStageProfile_Variation
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_regulated_nhr-62_dependent
      WBPaper00044037:eat-2_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00044786:lem-2(tm1582)_upregulated
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045521:Spermatogenic
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00049498:npr-1(ur89)_regulated_2
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050231:male_enriched
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053368:F.oxysporum_regulated
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053657:JU2519_M.humicola-infection_24hr
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059253:stearic-acid_downregulated
      WBPaper00059426:SiO2-nanoparticles_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060886:met-2(n4256)_upregulated
      WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:AIM
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:F42A9.7-T22B3.3
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062078:NMR-HspB1_regulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062305:P.brevicompactum_downregulated
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_downregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_14
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rde-3(ne298)_downregulated
      WBPaper00027111:rrf-1(pk1417)_downregulated
      WBPaper00027111:rrf-2(ok210)_downregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_E
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      [cgc6390]:Cluster_D
      [cgc6390]:spermatogenesis-enriched
    Interaction: WBInteraction000179280
      WBInteraction000284275
      WBInteraction000299751
      WBInteraction000349407
      WBInteraction000381031
      WBInteraction000399185
      WBInteraction000442032
      WBInteraction000503211
  Map_info: Map: IV Position: 4.4314 Error: 0.000485
    Positive: Positive_clone: K07F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003205
    WBPaper00027258
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene