WormBase Tree Display for Gene: WBGene00002064

WBGene00002064 SMap: S_parent: Sequence: T05G5
  Identity: Version: 1
    Name: CGC_name: iff-1 Person_evidence: WBPerson284
      Sequence_name: T05G5.10
      Molecular_name: T05G5.10a
        T05G5.10a.1
        CE37787
        T05G5.10b
        CE00503
        T05G5.10c
        CE46328
        T05G5.10b.1
        T05G5.10c.1
      Other_name: CELE_T05G5.10 Accession_evidence: NDB BX284603
      Public_name: iff-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: iff
    Allele (19)
    Strain: WBStrain00022686
      WBStrain00022688
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (38)
    Paralog: WBGene00002065 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: iff-1 encodes an eIF-5A homolog that affects fertility and is required for germ cell proliferation and for some P granule components to localize properly; expression is germline specific and mRNA is expressed in the distal region of gonads where germ cells actively proliferate. Paper_evidence: WBPaper00012310
            WBPaper00018717
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable translation elongation factor activity. Involved in gamete generation and protein localization. Predicted to be located in cytoplasm. Expressed in germ line and gonad. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human EIF5A (eukaryotic translation initiation factor 5A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3300)
  Molecular_info: Corresponding_CDS: T05G5.10a
      T05G5.10b
      T05G5.10c
    Corresponding_CDS_history: T05G5.10:wp135
    Corresponding_transcript: T05G5.10a.1
      T05G5.10b.1
      T05G5.10c.1
    Other_sequence (107)
    Associated_feature: WBsf651400
      WBsf667319
      WBsf667320
      WBsf993786
      WBsf1015666
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr2909
      Expr2911
      Expr2912
      Expr1021225
      Expr1031217
      Expr1156177
      Expr2012691
      Expr2030927
    Drives_construct: WBCnstr00036483
    Construct_product: WBCnstr00036483
    Regulate_expr_cluster: WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
    Antibody: WBAntibody00000726
    Microarray_results (23)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_lin-35
      WBPaper00032528:L3_enriched
      WBPaper00037047:insoluble_protein
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038118:stress_downregulated_N2
      WBPaper00038168:lin-35_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040446:insoluble_protein
      WBPaper00040529:TWE_regulated
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00041257:irradiation_downregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00043951:Nascent-polypeptide-associated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045316:prg-1_downregulated_L3
      WBPaper00045316:prg-1_downregulated_L4
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046446:rapid-synthesized_YoungAdult
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050225:flp-6(RNAi)_downregulated
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050599:nicotine(1mM)_upregulated
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:downregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054410:set-9(rw5)_upregulated
      WBPaper00055013:HMG-3_interacting_protein
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_downregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Germline
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061651:Germline_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:Sperm_enriched
      WBPaper00062002:Day4-adult_secretome
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062293:isp-1(qm150)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_downregulated_N2_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062715:blmp-1(s71)_downregulated
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064315:mes-4(bn73)_downregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064727:daf-2(e1370)_downregulated
      WBPaper00064789:Day12_vs_Day1_downregulated_neuron
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065623:1
      WBPaper00065623:8
      WBPaper00065623:12
      WBPaper00065623:14
      WBPaper00065623:21
      WBPaper00065623:22
      WBPaper00065623:27
      WBPaper00065749:endu-2(tm4977)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065841:3_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066038:mip-1(how5)_downregulated
      WBPaper00066085:hda-3(ok1991)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_3_1
      cgc4489_group_2
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00034739:TreatmentAffectedGenes
      WBPaper00036286:Pattern_B
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00044535:male_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (346)
  Map_info: Map: III Position: 0.949142 Error: 0.006732
    Positive: Positive_clone: T05G5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4195
        4435
    Pseudo_map_position
  Reference (15)
  Remark (2)
  Method: Gene