WormBase Tree Display for Gene: WBGene00000457

WBGene00000457 SMap: S_parent: Sequence: C37E2
  Identity: Version: 1
    Name: CGC_name: ceh-36 Person_evidence: WBPerson83
      Sequence_name: C37E2.4
      Molecular_name (3)
      Other_name: CELE_C37E2.4 Accession_evidence: NDB BX284606
      Public_name: ceh-36
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ceh
    Allele (73)
    Strain (28)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (23)
    Paralog (20)
    Structured_description: Concise_description: ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTX/OTD) homeodomain proteins in C. elegans (the others being TTX-1 and CEH-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. Paper_evidence: WBPaper00006146
          Curator_confirmed: WBPerson1843
          Date_last_updated: 03 Nov 2008 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron fate specification; positive regulation of transcription by RNA polymerase II; and sensory perception of chemical stimulus. Located in nucleus. Expressed in ABaraappa; ABaraappaa; amphid neurons; and head neurons. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 5. Is an ortholog of human ARGFX (arginine-fifty homeobox); DPRX (divergent-paired related homeobox); and NOBOX (NOBOX oogenesis homeobox). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080862 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:22448)
  Molecular_info: Corresponding_CDS: C37E2.4
    Corresponding_transcript: C37E2.4.1
    Other_sequence: Acan_isotig20892
      CRC06706_1
      Dviv_isotig18862
      CR03746
      Dviv_isotig18863
    Associated_feature (13)
    Gene_product_binds: WBsf047574
      WBsf047577
      WBsf979157
    Transcription_factor: WBTranscriptionFactor000158
  Experimental_info: RNAi_result: WBRNAi00093990 Inferred_automatically: RNAi_primary
      WBRNAi00001118 Inferred_automatically: RNAi_primary
      WBRNAi00029642 Inferred_automatically: RNAi_primary
      WBRNAi00011721 Inferred_automatically: RNAi_primary
      WBRNAi00042116 Inferred_automatically: RNAi_primary
    Expr_pattern (23)
    Drives_construct (46)
    Construct_product: WBCnstr00007677
      WBCnstr00010927
      WBCnstr00011003
      WBCnstr00018896
      WBCnstr00022542
      WBCnstr00022977
      WBCnstr00037522
    Microarray_results (19)
    Expression_cluster: WBPaper00032976:non_compensated_genes
      WBPaper00035197:fer-1_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00040285:H2S_24hr_upregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00045050:csr-1(hypomorph)_upregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049954:BPA_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050903:mir-35-41(nDf50)_25C_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056446:hsb-1(cg116)_upregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_downregulated
      WBPaper00059728:20ug_cholesterol_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ASE
      WBPaper00061340:ASE_parent
      WBPaper00061340:AWC
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_downregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:cfz-2_18944-cfz-2_2268
      WBPaper00061651:ASEL_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:AWC_OFF_enriched
      WBPaper00061651:AWC_ON_enriched
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_transcript
      WBPaper00062456:doxycycline_downregulated_N2_transcript
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065746:eat-2(ad1113)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:35_2
      WBPaper00065841:35_3
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4489_group_21
      WBPaper00025032:cluster_5
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00036286:Pattern_F
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(83_min)
    Interaction (126)
    Anatomy_function: WBbtf0392
  Map_info: Map: X Position: 16.6588 Error: 0.001314
    Positive: Positive_clone: C37E2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4209
    Pseudo_map_position
  Reference (87)
  Remark: [Burglin T] registered gene name
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene