| WBGene00000435 | SMap | S_parent | Sequence | W03A3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | ceh-10 | Person_evidence | WBPerson83 |
| | | Sequence_name | W03A3.1 |
| | | Molecular_name | W03A3.1 |
| | | | W03A3.1.1 |
| | | | CE07563 |
| | | Other_name | mig-11 |
| | | | CELE_W03A3.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | ceh-10 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ceh |
| | Allele (48) |
| | Legacy_information | [C.elegansII] NMK. 1.2 kb transcript, encodes 344 aa Paired-like class homeoprotein; extensive similarity to mouse Chx10, goldfish Vsx-1. ceh-10:lacZ expressed maximally in embryo,from250-300 cell stage, lower in larvae, in certain neuronal nuclei (interneurons AIY, AIN; sensoryneurons CEPD, motor neurons RID, RMED; CAN cellsetc.). Transgene can induce defects in CAN cell migration and withered tail phenotype. [Hawkins and McGhee 1990; Svendsen and McGhee 1995; JM] |
| | | [C.elegansII] NMK. 1.2 kb transcript, encodes 344 aa Paired-like class homeoprotein; extensive similarity to mouse Chx10, goldfish Vsx-1. ceh-10:lacZ expressed maximally in embryo, from 250-300 cell stage, lower in larvae, in certain neuronal nuclei (interneurons AIY, AIN; sensory neurons CEPD, motor neurons RID, RMED; CAN cells etc.). Transgene can induce defects in CAN cell migration and withered tail phenotype. [Hawkins and McGhee 1990; Svendsen and McGhee 1995; JM] |
| | | [Forrester WC] gm120 homozygotes viable, occasionally Unc, Egl, Muv, withered tail. G to A change at first intron donor. OA6: gm127 resembles gm120, gm58 etc all die as Clr larvae. gm100, gm133 nonsense mutations. |
| | | [C.elegansII] ct78 : defective CAN migrations; other migrations defective at low penetrance. [LK; CX] |
| | Strain | WBStrain00028735 |
| | | WBStrain00003961 |
| | | WBStrain00033854 |
| | | WBStrain00050483 |
| | RNASeq_FPKM (74) |
| | GO_annotation (23) |
| | Ortholog (37) |
| | Paralog (20) |
| | Structured_description | Concise_description | ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons. | Paper_evidence | WBPaper00001346 |
| | | | | | WBPaper00002186 |
| | | | | | WBPaper00002978 |
| | | | | | WBPaper00004727 |
| | | | | Curator_confirmed (2) |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalapppaa; CAN; head neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in eye disease (multiple). Is an ortholog of human VSX2 (visual system homeobox 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed (2) |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0060839 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1975) |
| | | DOID:1432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1975) |
| | | DOID:10126 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12723) |
| | | EFO:MONDO:0000170 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1975) |
| | | DOID:0110855 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12723) |
| | | DOID:2566 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12723) |
| Molecular_info | Corresponding_CDS | W03A3.1 |
| | Corresponding_transcript | W03A3.1.1 |
| | Other_sequence (14) |
| | Associated_feature | WBsf658992 |
| | | WBsf978897 |
| | | WBsf992534 |
| | | WBsf224996 |
| | Transcription_factor | WBTranscriptionFactor000033 |
| | | WBTranscriptionFactor000606 |
| Experimental_info | RNAi_result | WBRNAi00084771 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027655 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075607 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00019528 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00054638 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00084769 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005463 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00000885 |
| | | WBCnstr00000886 |
| | | WBCnstr00001673 |
| | | WBCnstr00001674 |
| | | WBCnstr00001675 |
| | | WBCnstr00005975 |
| | | WBCnstr00012841 |
| | | WBCnstr00014232 |
| | | WBCnstr00020303 |
| | | WBCnstr00020304 |
| | Construct_product | WBCnstr00001599 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_5day_downregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045861:wdr-5(ok1417)_upregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set2 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:seam_enriched |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055226:ADR-2_target_adr-1(tm668) |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:hypoxia_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:Neuroblast_ALA_RMED |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:pie-1(ne4433)_upregulated |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062184:PA14_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00064509:static-magnetic-field_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065841:40_0 |
| | | WBPaper00065841:69_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:112_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00025032:cluster_37 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00044535:male_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(186_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(186_min) |
| | Interaction (61) |
| Map_info | Map | III | Position | -1.44616 | Error | 0.00013 |
| | Well_ordered |
| | Positive | Positive_clone | JM#L1003 |
| | | | W03A3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3715 |
| | | | 1499 |
| | | | 1500 |
| | | | 1501 |
| | | | 1502 |
| | | | 4431 |
| | | Pos_neg_data | 4233 |
| | | | 4234 |
| Reference (55) |
| Remark | Data extracted from Forrester et al. (1998) |
| | mig-11 fused into this. Canonical allele ct78 is a deletion of the C-terminus of ceh-10 and has anomalous complementation . ct78 complements CAN-defective ceh-10 null alleles but fails to complement ceh-10 alleles with respect to ttx-3 expression. [Hobert O, Wenick AS, Buelow H] |
| Method | Gene |
