WormBase Tree Display for Gene: WBGene00003335

WBGene00003335 Evidence: Paper_evidence: WBPaper00005825
  SMap: S_parent: Sequence: F56A12
  Identity: Version: 1
    Name: CGC_name: mir-241 Person_evidence: WBPerson18
      Sequence_name: F56A12.4
      Molecular_name: F56A12.4
        F56A12.4a
        F56A12.4b
      Other_name: cel-mir-241 Remark: miRBase V21 import
        Cel-Let-7-P8 Remark: MirGeneDB 2.1 import
        CELE_F56A12.4 Accession_evidence: NDB BX284605
      Public_name: mir-241
    DB_info: Database: miRBase acc MI0000317
        SignaLink mirna cel-mir-241
        MirGeneDB cel Cel-Let-7-P8
        NDB locus_tag CELE_F56A12.4
        NCBI gene 3565950
        RefSeq protein NR_002403.2
        RNAcentral URSid URS00002BFC83
            URS000040AE62
            URS000040F239
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001265
    Gene_class: mir
    Allele (11)
    Strain: WBStrain00027442
      WBStrain00027449
      WBStrain00027441
      WBStrain00040223
      WBStrain00040225
      WBStrain00040228
      WBStrain00051617
    In_cluster: LET-7
    RNASeq_FPKM (74)
    GO_annotation: 00106260
      00106261
    Structured_description: Concise_description: mir-241 encodes a microRNA, a small non-protein coding RNA and appears to have a potential ortholog in C. briggsae; based on RNA sequence identity, miR-241 belongs to the let-7 family of microRNAs along with C. elegans miR-48 and miR-84 and human let-7, miR-196-1 and miR-196-2; mir-241 acts redundantly with miR-48 and mir-84 to control L2 to L3 larval and larval to adult stage transitions; miR-241 is strongly expressed from the L3 larval stage into the adult stage in normal worms and in glp-4(bn2) mutant worms. Paper_evidence: WBPaper00005825
            WBPaper00010853
          Curator_confirmed: WBPerson324
          Date_last_updated: 08 Feb 2005 00:00:00
      Automated_description: Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in body wall musculature; excretory canal; hermaphrodite distal tip cell; and touch receptor neurons. Used to study Parkinson's disease. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14330 Homo sapiens Paper_evidence: WBPaper00035654
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jan 2014 00:00:00
    Disease_relevance: mir-241 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies indicate that mir-241 is overexpressed in an elegans Parkinson''s disease model, the pdr-1 mutant (pdr-1 is orthologous to human PARKIN). Homo sapiens Paper_evidence: WBPaper00035654
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jan 2014 00:00:00
  Models_disease_in_annotation: WBDOannot00000268
  Molecular_info: Corresponding_transcript: F56A12.4
      F56A12.4a
      F56A12.4b
    Associated_feature: WBsf034325
      WBsf979128
      WBsf1001991
      WBsf1001992
      WBsf1001993
      WBsf1001994
      WBsf1020828
      WBsf1020829
      WBsf1020830
      WBsf1020831
  Experimental_info: Expr_pattern (11)
    Drives_construct: WBCnstr00005522
      WBCnstr00011651
      WBCnstr00015774
      WBCnstr00015775
      WBCnstr00017833
    Construct_product: WBCnstr00015775
    Expression_cluster: WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040221:DAF-12_target_ALF9
      WBPaper00042480:20mM_nicotine_upregulated
      WBPaper00045316:miRNA_N2_L1_vs_embryo_downregulated_adult
      WBPaper00045316:miRNA_N2_L2_vs_L1_upregulated_adult
      WBPaper00045316:miRNA_N2_L3_vs_L2_upregulated_adult
      WBPaper00045316:miRNA_prg-1_downregulated_adult
      WBPaper00045316:miRNA_prg-1_downregulated_embryo
      WBPaper00045316:miRNA_prg-1_downregulated_L3
      WBPaper00045316:miRNA_prg-1_downregulated_L4
      WBPaper00045316:miRNA_prg-1_L1_vs_embryo_upregulated_adult
      WBPaper00045316:miRNA_prg-1_L2_vs_L1_upregulated_adult
      WBPaper00045316:miRNA_prg-1_L3_vs_L2_upregulated_adult
      WBPaper00045316:miRNA_prg-1_L4_vs_L3_upregulated_adult
      WBPaper00045316:miRNA_prg-1_upregulated_adult
      WBPaper00045316:miRNA_prg-1_upregulated_L1
      WBPaper00045316:miRNA_prg-1_upregulated_L2
      WBPaper00045316:miRNA_prg-1_upregulated_L4
      WBPaper00046156:eat-2(ad1116)_Day1_upregulated
      WBPaper00046156:eat-2(ad1116)_Day8_downregulated
      WBPaper00046303:P.aeruginosa_upregulated_miRNA
      WBPaper00051404:alg-1(gk214)_downregulated_miRNA
      WBPaper00051404:alg-1(gk214)_upregulated_miRNA
      WBPaper00051404:alg-2(ok304)_downregulated_miRNA
      WBPaper00051404:alg-2(ok304)_upregulated_miRNA
      WBPaper00051404:alg-5(ram2)_downregulated_miRNA
      WBPaper00051404:alg-5(ram2)_upregulated_miRNA
      WBPaper00051404:alg-5(tm1163)_upregulated_miRNA
      WBPaper00053318:Aging_downregulated_miRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_miRNA
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057033:pry-1(mu38)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00060100:SiNP_upregulated_miRNA
      WBPaper00062103:neuron_enriched
      WBPaper00064661:lpd-3(ok2138)_upregulated
    Interaction (17)
    WBProcess: WBbiopr:00000083
  Map_info: Map: V Position: 6.27847 Error: 0.001234
    Positive: Inside_rearr: nDf51
      Positive_clone: F56A12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5653
      Pos_neg_data: 10750
    Pseudo_map_position
  Reference: WBPaper00005825
    WBPaper00006075
    WBPaper00010853
    WBPaper00019714
    WBPaper00025627
    WBPaper00026043
    WBPaper00026424
    WBPaper00026716
    WBPaper00026780
    WBPaper00026781
    WBPaper00026854
    WBPaper00027282
    WBPaper00030565
    WBPaper00031335
    WBPaper00031783
    WBPaper00032187
    WBPaper00032188
    WBPaper00032329
    WBPaper00032617
    WBPaper00032670
    WBPaper00032974
    WBPaper00033044
    WBPaper00034321
    WBPaper00034339
    WBPaper00034907
    WBPaper00035307
    WBPaper00035664
    WBPaper00036027
    WBPaper00036657
    WBPaper00038300
    WBPaper00039005
    WBPaper00039546
    WBPaper00040016
    WBPaper00041805
    WBPaper00042343
    WBPaper00043012
    WBPaper00043069
    WBPaper00043713
    WBPaper00043840
    WBPaper00043989
    WBPaper00045070
    WBPaper00046619
    WBPaper00048181
    WBPaper00049569
    WBPaper00050411
    WBPaper00052242
    WBPaper00052450
    WBPaper00052460
    WBPaper00054726
    WBPaper00056761
    WBPaper00058225
    WBPaper00058226
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene