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WormBase Tree Display for Gene: WBGene00000112

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Name Class

WBGene00000112SMapS_parentSequenceY57G7A
IdentityVersion2
NameCGC_namealh-6Person_evidenceWBPerson651
Sequence_nameF56D12.1
Molecular_name (13)
Other_namexrep-2Paper_evidenceWBPaper00051108
CELE_F56D12.1Accession_evidenceNDBBX284602
Public_namealh-6
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
216 May 2017 09:45:54WBPerson2970Name_changeOther_namexrep-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classalh
Allele (200)
RNASeq_FPKM (74)
GO_annotation (14)
Contained_in_operonCEOP2044
Ortholog (43)
Paralog (11)
Structured_descriptionConcise_descriptionalh-6 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 4 FAMILY, MEMBER A1 (ALDH4A1; OMIM:606811), which when mutated leads to hyperprolinemia type II.Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrial matrix. Expressed in head and tail. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Is an ortholog of human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080543Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:406)
Molecular_infoCorresponding_CDSF56D12.1a
F56D12.1b
F56D12.1c
F56D12.1d
Corresponding_transcriptF56D12.1a.1
F56D12.1a.2
F56D12.1b.1
F56D12.1c.1
F56D12.1d.1
Other_sequence (68)
Associated_feature (11)
Experimental_infoRNAi_result (13)
Expr_patternChronogram1568
Expr6220
Expr1014020
Expr1030059
Expr1152446
Expr2009308
Expr2027544
Drives_constructWBCnstr00002586
Regulate_expr_clusterWBPaper00059231:alh-6(lax105)_D3Adult_downregulated
WBPaper00059231:alh-6(lax105)_D3Adult_upregulated
WBPaper00059231:alh-6(lax105)_L4_downregulated
WBPaper00059231:alh-6(lax105)_L4_upregulated
Microarray_results (44)
Expression_clusterWBPaper00029359_1197
WBPaper00029359_1225
WBPaper00029359_1291
WBPaper00029359_1494
WBPaper00029359_1546
WBPaper00037946:LIN-39_interacting
WBPaper00038289:oocyte_protein
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00044786:lem-2(tm1582)_upregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00046446:rapid-synthesized_AgingAdult
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:daf-16(mu86)_upregulated_neuron
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049626:UNC-75_target
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050599:nicotine(0.01mM)_upregulated
WBPaper00050599:nicotine(1mM)_upregulated
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_OP50
WBPaper00053814:25C_upregulated_PY79
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059816:crh-1(n3315)_downrgulated
WBPaper00059895:wounding_downregulated
WBPaper00059987:Wounding_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061377:MYRF-1_interacting
WBPaper00061527:atad-3-mpst-1
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:daf-16(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064315:mes-3(bn199)_downregulated_EGCs
WBPaper00064315:mes-4(bn73)_downregulated_EGCs
WBPaper00064494:postdauer_downregulated_AWA
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065086:N2_N.parisii_regulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00025032:cluster_34
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031832:slr-2_regulated
WBPaper00032165:differentially_expressed_with_age_medoid_7
WBPaper00032948:StarveUp1
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035873:dpy-10_regulated
WBPaper00036286:Pattern_G
WBPaper00038060:SUMO-1_upregulated
WBPaper00038172:crh-1null_up_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00045960:L1-L4-lethargus_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
Interaction (68)
Map_infoMapIIPosition-15.5079Error0.004302
PositivePositive_cloneF56D12Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00038491
WBPaper00040958
WBPaper00041713
WBPaper00042257
WBPaper00044733
WBPaper00045841
WBPaper00047646
WBPaper00051108
WBPaper00052171
WBPaper00055090
WBPaper00057533
WBPaper00060917
WBPaper00062816
WBPaper00063995
WBPaper00064934
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene