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WormBase Tree Display for Gene: WBGene00003482

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Name Class

WBGene00003482EvidenceCGC_data_submission
SMapS_parentSequenceCHROMOSOME_III
IdentityVersion1
NameCGC_namemua-3Person_evidenceWBPerson1052
Sequence_nameK08E5.3
Molecular_nameK08E5.3a
K08E5.3a.1
CE28049
K08E5.3b
CE37256
K08E5.3b.1
Other_nameCELE_K08E5.3Accession_evidenceNDBBX284603
Public_namemua-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmua
Allele (324)
Legacy_information[C.elegansII] rh169 : progressive detachment of muscles during larval development, possibly defective in reformation of muscle-cuticle links at each molt. Cloned: encodes predicted 3617 aa protein with TM domain, large extracellular domain containing 52 EGF repeats, 5 LDL repeats, etc. [NJ]
StrainWBStrain00030527
WBStrain00007983
RNASeq_FPKM (74)
GO_annotation (12)
OrthologWBGene00054936Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00030816Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00031318Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00144079Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00129092Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00231761Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g5582Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g6603Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g17495Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP26.g17497Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g20497Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP28.g20498Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g23251Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g22019Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g5921Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g12038Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g19945Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g8059Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g8061Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00300.g8783Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_08096.g21287Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_III.g10527Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_III.g10529Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g10216Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00155.g5831Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_03088.g29018Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_19539Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_009604Caenorhabditis remaneiFrom_analysisWormBase-Compara
GCK72_009606Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g04781Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g22457Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_30209000Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g8812Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00176233Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00217555Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00244328Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00090464Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00263241Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00290319Trichuris murisFrom_analysisWormBase-Compara
HGNC:6909Homo sapiensFrom_analysisOrthoInspector
PhylomeDB
MGI:1328314Mus musculusFrom_analysisOrthoInspector
PhylomeDB
RGD:1309732Rattus norvegicusFrom_analysisOrthoInspector
PhylomeDB
Paralog (13)
Structured_descriptionAutomated_descriptionPredicted to enable collagen binding activity and intermediate filament binding activity. Involved in cell-matrix adhesion. Located in hemidesmosome and intermediate filament. Expressed in several structures, including amphid neurons; enteric muscle; excretory system; phasmid sensillum; and rectum. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5 and osteoarthritis. Is an ortholog of human MATN3 (matrilin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14323Homo sapiensPaper_evidenceWBPaper00046710
Accession_evidenceOMIM154700
Curator_confirmedWBPerson324
Date_last_updated05 Aug 2015 00:00:00
Potential_modelDOID:2256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6909)
DOID:0070299Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6909)
DOID:8398Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6909)
Disease_relevanceMutations in the human gene FBN1 (Fibrillin 1) are implicated in Marfan syndrome, a heritable autosomal dominant disorder of fibrous connective tissue; signs and symptoms of Marfan syndrome vary widely in severity, timing of onset, and rate of progression; the primary features of Marfan syndrome are vision problems caused by a dislocated lens, connective tissue and skeletal defects such as elongated extremities, joint hypermobility and scoliosis; C. elegans mua-3 shares high homology with FBN1, mua-3 is required for tissue integrity and attachment, mua-3 mutants show internal organ detachment; further studies in C. elegans indicate that dpy-17, a collagen acts as a genetic suppressor of mua-3, and interacts with dpy-31, a BMP-1/Tolloid-like metalloprotease required for TGF activation in mammals; knock-down of dbl-1, a TGF homolog, in mua-3 modestly rescued the lethality of mua-3 mutants, suggesting a potentially conserved interaction between MUA-3 and a TGF pathway; these genes provide a genetic model to study TGF function in development of Marfan pathology.Homo sapiensPaper_evidenceWBPaper00004799
WBPaper00046710
Accession_evidenceOMIM154700
134797
Curator_confirmedWBPerson324
Date_last_updated25 Sep 2015 00:00:00
Models_disease_in_annotationWBDOannot00000360
Molecular_infoCorresponding_CDSK08E5.3a
K08E5.3b
Corresponding_CDS_historyK08E5.3:wp52
Corresponding_transcriptK08E5.3a.1
K08E5.3b.1
Other_sequence (49)
Associated_feature (21)
Experimental_infoRNAi_result (26)
Expr_patternExpr1627
Expr1015401
Expr1031597
Expr1154001
Expr2013822
Expr2032062
AntibodyWBAntibody00000392
Microarray_results (26)
Expression_clusterWBPaper00005700:transmembrane_protein
WBPaper00030922:glycosylated_protein
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
WBPaper00042561:smg-2(RNAi)_downregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045521:Spermatogenic
WBPaper00046121:ecdoderm_unique
WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048988:neuron_expressed
WBPaper00049098:heat-induced_N2
WBPaper00049377:MWCNT_upregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049635:dop-1(vs100)_upregulated
WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_downregulated
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050743:elli-1(sam-3)_downregulated
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_specific
WBPaper00051265:F1_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051404:alg-2(ok304)_downregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053599:female_vs_male_downregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053814:15C_downregulated_PY79
WBPaper00053814:25C_upregulated_OP50
WBPaper00054192:cold-shock_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055969:electromagnetic-field_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056039:efa-6(tm3124)_upregulated
WBPaper00056039:ptrn-1(tm5597)_downregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056169:rrf-3(pk1426)_upregulated_L1
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056330:glycine_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058711:wdr-5(ok1417)_upregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059529:nonu-1(srf0780)_upregulated
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059605:mut-16(pk710)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-infection_24h_regulated
WBPaper00060886:spr-5(by101)_upregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ADEsh
WBPaper00061340:AMso
WBPaper00061340:AMso_parent
WBPaper00061340:B
WBPaper00061340:CEPso
WBPaper00061340:Excretory_gland
WBPaper00061340:G2_and_W_blasts
WBPaper00061340:Glia
WBPaper00061340:hyp1V_and_ant_arc_V
WBPaper00061340:hyp4_hyp5_hyp6
WBPaper00061340:ILso
WBPaper00061340:Parent_of_hyp3_ILsoDx
WBPaper00061340:P_cell
WBPaper00061340:Y
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:176662_at-Y53F4B.16
WBPaper00061527:ttr-18-C54D10.3
WBPaper00061651:AIN_enriched
WBPaper00061651:AMso_enriched
WBPaper00061651:PHso_enriched
WBPaper00061651:VD_DD_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:daf-16(RNAi)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
WBPaper00064130:Beta-Amyloid_upregulated_protein
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-3(bn199)_downregulated_EGCs
WBPaper00064315:mes-4(bn73)_downregulated_EGCs
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064728:cpl-1(W32AY35A)_upregulated
WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
WBPaper00064952:Day5_vs_L4_downregulated_20C
WBPaper00064952:Day10_vs_L4_downregulated_20C
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065841:30_1
WBPaper00065841:64_0
WBPaper00065841:79_0
WBPaper00065841:82_0
WBPaper00065841:82_1
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_5
cgc4489_group_20
WBPaper00025141:N2_Expressed_Genes
WBPaper00026952:class_E
WBPaper00028789:PA14_vs_gacA_downregulated_8hr
WBPaper00028789:PA14_vs_OP50_downregulated_8hr
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032165:A_to_C_transit_increased
WBPaper00032948:FedUp
WBPaper00034739:N2lessDR1350
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_C
WBPaper00036464:S.aureus-RN6390_regulated
WBPaper00037695:WC_5-day
WBPaper00038462:aging_downregulated
WBPaper00040210:Chlorpyrifos_16C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041174:environmental
WBPaper00041174:genotypic
WBPaper00041174:genotypic_and_environmental
WBPaper00041207:CE_dauer_down
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-exposed_48h
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00045960:L4-lethargus_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00050650:mBmkTX_downregulated
WBPaper00053236:Starvation_regulated_N2
WBPaper00055899:nitroguanidine_regulated
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc5976]:class_2
[cgc6390]:Cluster_C
Interaction (27)
WBProcessWBbiopr:00000006
Map_infoMapIIIPosition1.97555Error0.010818
Well_ordered
PositivePositive_cloneK08E5Inferred_automaticallyFrom sequence, transcript, pseudogene data
T20G5
Mapping_dataMulti_point2243
2244
2246
3172
3177
3178
5446
Reference (35)
RemarkSequence connection from [Plenefisch JD]
MethodGene