WormBase Tree Display for Gene: WBGene00016408

WBGene00016408 SMap: S_parent: Sequence: C34E10
  Identity: Version: 3
    Name: CGC_name: prmt-5 Person_evidence: WBPerson4055
      Sequence_name: C34E10.5
      Molecular_name: C34E10.5
        C34E10.5.1
        CE29033
        C34E10.5.2
        C34E10.5.3
      Other_name: tag-251 Person_evidence: WBPerson201
        CELE_C34E10.5 Accession_evidence: NDB BX284603
      Public_name: prmt-5
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 20 Jul 2007 11:50:19 WBPerson2970 Name_change: CGC_name: prmt-5
        3 20 Jul 2007 11:50:19 WBPerson2970 Name_change: Other_name: tag-251
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: prmt
    Allele (48)
    Strain: WBStrain00036097
    RNASeq_FPKM (74)
    GO_annotation (42)
    Contained_in_operon: CEOP3268
    Ortholog (36)
    Structured_description: Automated_description: Enables DNA-binding transcription factor binding activity; p53 binding activity; and protein methyltransferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of DNA damage response, signal transduction by p53 class mediator; and response to odorant. Located in nucleus. Human ortholog(s) of this gene implicated in Leydig cell tumor and seminoma. Is an ortholog of human PRMT5 (protein arginine methyltransferase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2696 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10894)
      DOID:4440 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10894)
  Molecular_info: Corresponding_CDS: C34E10.5
    Corresponding_transcript: C34E10.5.1
      C34E10.5.2
      C34E10.5.3
    Other_sequence (21)
    Associated_feature (2)
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr1018696
      Expr1037030
      Expr1145902
      Expr2015099
      Expr2033337
    Drives_construct: WBCnstr00028094
    Construct_product: WBCnstr00028094
    Antibody: WBAntibody00002111
    Microarray_results (22)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045693:S.flexneri_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051311:VGLN-1-interacting
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_15
      WBPaper00025032:cluster_6
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00045673:colistin_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:intrinsic
    Interaction: WBInteraction000041221
      WBInteraction000044229
      WBInteraction000049550
      WBInteraction000049551
      WBInteraction000106333
      WBInteraction000119868
      WBInteraction000123561
      WBInteraction000148678
      WBInteraction000159366
      WBInteraction000159367
      WBInteraction000170034
      WBInteraction000170035
      WBInteraction000170036
      WBInteraction000173919
      WBInteraction000174384
      WBInteraction000174385
      WBInteraction000174386
      WBInteraction000180199
      WBInteraction000183629
      WBInteraction000195854
      WBInteraction000207863
      WBInteraction000219499
      WBInteraction000219500
      WBInteraction000219501
      WBInteraction000220715
      WBInteraction000233987
      WBInteraction000263726
      WBInteraction000274986
      WBInteraction000281676
      WBInteraction000284138
      WBInteraction000284139
      WBInteraction000284140
      WBInteraction000284141
      WBInteraction000284142
      WBInteraction000284143
      WBInteraction000284144
      WBInteraction000284145
      WBInteraction000284146
      WBInteraction000284147
      WBInteraction000284148
      WBInteraction000284149
      WBInteraction000284150
      WBInteraction000284151
      WBInteraction000284152
      WBInteraction000284153
      WBInteraction000286411
      WBInteraction000288971
      WBInteraction000301246
      WBInteraction000301974
      WBInteraction000303576
      WBInteraction000308156
      WBInteraction000315525
      WBInteraction000320224
      WBInteraction000330113
      WBInteraction000334471
      WBInteraction000336248
      WBInteraction000340589
      WBInteraction000344016
      WBInteraction000347404
      WBInteraction000347713
      WBInteraction000352938
      WBInteraction000353479
      WBInteraction000353624
      WBInteraction000359865
      WBInteraction000360063
      WBInteraction000372634
      WBInteraction000378292
      WBInteraction000390164
      WBInteraction000398431
      WBInteraction000400475
      WBInteraction000403306
      WBInteraction000404569
      WBInteraction000406126
      WBInteraction000406336
      WBInteraction000408063
      WBInteraction000408350
      WBInteraction000409736
      WBInteraction000413001
      WBInteraction000420459
      WBInteraction000432644
      WBInteraction000439304
      WBInteraction000442136
      WBInteraction000443622
      WBInteraction000443649
      WBInteraction000445868
      WBInteraction000446698
      WBInteraction000448392
      WBInteraction000456103
      WBInteraction000464403
      WBInteraction000464703
      WBInteraction000466510
      WBInteraction000521793
      WBInteraction000521794
      WBInteraction000521795
      WBInteraction000521796
      WBInteraction000521797
      WBInteraction000521798
      WBInteraction000521800
      WBInteraction000522320
      WBInteraction000522321
      WBInteraction000522322
      WBInteraction000522324
      WBInteraction000522325
      WBInteraction000522327
      WBInteraction000525489
      WBInteraction000551927
      WBInteraction000562596
      WBInteraction000562597
      WBInteraction000570768
      WBInteraction000570827
      WBInteraction000573829
  Map_info: Map: III Position: -1.87136 Error: 0.010434
    Positive: Positive_clone: C34E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5207
        4167
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene