| WBGene00003890 | SMap | S_parent | Sequence | T20H4 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | osm-10 | Person_evidence | WBPerson242 |
| | | Sequence_name | T20H4.1 |
| | | Molecular_name | T20H4.1a |
| | | | T20H4.1a.1 |
| | | | CE00750 |
| | | | T20H4.1b |
| | | | CE51605 |
| | | | T20H4.1b.1 |
| | | Other_name | CELE_T20H4.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | osm-10 |
| | DB_info | Database | AceView | gene | 3I337 |
| | | | WormQTL | gene | WBGene00003890 |
| | | | WormFlux | gene | WBGene00003890 |
| | | | OMIM | disease | 256000 |
| | | | | gene | 602141 |
| | | | NDB | locus_tag | CELE_T20H4.1 |
| | | | NCBI | gene | 191740 |
| | | | RefSeq | protein | NM_001330924.2 |
| | | | | | NM_066197.7 |
| | | | TrEMBL | UniProtAcc | A0A168H2S6 |
| | | | | | Q22622 |
| | | | UniProt_GCRP | UniProtAcc | Q22622 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | osm |
| | Allele (30) |
| | Legacy_information | [C.elegansII] n1602 : specifically defective in osmotic avoidance; normal chemotaxis; normal garlic avoidance; normal nose touch response. NA1. Cloned: cosmid rescue [Bargmann et al. 1990; CX, KP] |
| | Strain | WBStrain00008277 |
| | | WBStrain00008292 |
| | | WBStrain00008293 |
| | | WBStrain00008294 |
| | | WBStrain00029473 |
| | | WBStrain00027082 |
| | RNASeq_FPKM (74) |
| | GO_annotation (12) |
| | Ortholog (22) |
| | Structured_description | Concise_description | osm-10 encodes a novel protein conserved amongst several Caenorhabditis species; osm-10 activity is required for normal osmosensory signaling in the ASH sensory neuron; in regulating ASH-mediated osmosensation, osm-10 interacts genetically with eos-1 and eos-2; OSM-10 is expressed in the ASH, ASI, PHA, and PHB sensory neurons beginning just prior to hatching and continuing through larval and adult stages; OSM-10 localizes to cell bodies, sensory processes, and axons. | Paper_evidence | WBPaper00003408 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 25 Sep 2006 00:00:00 |
| | | Automated_description | Enables osmosensor activity. Involved in osmosensory signaling pathway. Located in axon; cytoplasm; and neuronal cell body. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Disease_relevance | Mutations in the human NADH-Ubiquinone oxidoreductase Fe-S protein 8 (NDUFS8; orthologous to elegans T20H4.1), are associated with Leigh syndrome, which is an an early-onset progressive neurodegenerative disorder, characterized by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within a couple of years, usually due to respiratory failure. | Homo sapiens | Accession_evidence | OMIM | 256000 |
| | | | | | | 602141 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 15 Jun 2012 00:00:00 |
| Molecular_info | Corresponding_CDS | T20H4.1a |
| | | T20H4.1b |
| | Corresponding_transcript | T20H4.1a.1 |
| | | T20H4.1b.1 |
| | Associated_feature | WBsf645329 |
| | | WBsf225227 |
| | | WBsf225228 |
| | | WBsf225229 |
| Experimental_info | RNAi_result | WBRNAi00035727 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00053670 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00018934 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005588 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065896 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Chronogram614 |
| | | Expr515 |
| | | Expr1266 |
| | | Expr6725 |
| | | Expr15400 |
| | | Expr1022236 |
| | | Expr1031833 |
| | | Expr1157225 |
| | | Expr2014639 |
| | | Expr2032872 |
| | Drives_construct (17) |
| | Construct_product | WBCnstr00012411 |
| | | WBCnstr00022367 |
| | | WBCnstr00035810 |
| | Antibody | WBAntibody00000213 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-CEM-neurons_expressed |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059490:dcr-1(m9375)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:ASH |
| | | WBPaper00061527:xbx-3-DH11.5_20397 |
| | | WBPaper00061651:ASH_enriched |
| | | WBPaper00061651:ASI_enriched |
| | | WBPaper00061651:PHA_enriched |
| | | WBPaper00061651:PHB_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_BAG |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:106 |
| | | WBPaper00065623:133 |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:47_0 |
| | | WBPaper00065841:47_1 |
| | | WBPaper00065841:77_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_9 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | Interaction | WBInteraction000000797 |
| | | WBInteraction000000798 |
| | | WBInteraction000126393 |
| | | WBInteraction000147211 |
| | | WBInteraction000161324 |
| | | WBInteraction000180432 |
| | | WBInteraction000188286 |
| | | WBInteraction000256324 |
| | | WBInteraction000304021 |
| | | WBInteraction000352848 |
| | | WBInteraction000412807 |
| | | WBInteraction000466208 |
| | | WBInteraction000569148 |
| | | WBInteraction000569149 |
| Map_info | Map | III | Position | -0.764685 | Error | 0.000739 |
| | Well_ordered |
| | Positive | Positive_clone | T20H4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 3719 |
| | | Multi_point | 1363 |
| | | | 4042 |
| | | | 4043 |
| | | | 4146 |
| | | Pos_neg_data | 3720 |
| | | | 3721 |
| Reference (39) |
| Method | Gene |
