WormBase Tree Display for Gene: WBGene00002068

WBGene00002068 Evidence: Paper_evidence: WBPaper00005604
  SMap: S_parent: Sequence: C27A2
  Identity: Version: 1
    Name: CGC_name: ify-1 Person_evidence: WBPerson533
      Sequence_name: C27A2.3
      Molecular_name: C27A2.3
        C27A2.3.1
        CE04103
      Other_name: CELE_C27A2.3 Accession_evidence: NDB BX284602
      Public_name: ify-1
    DB_info: Database: AceView gene 2F344
        WormQTL gene WBGene00002068
        WormFlux gene WBGene00002068
        NDB locus_tag CELE_C27A2.3
        NCBI gene 173872
        RefSeq protein NM_062530.11
        SwissProt UniProtAcc Q18235
        TREEFAM TREEFAM_ID TF318045
        UniProt_GCRP UniProtAcc Q18235
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ify
    Allele (18)
    Strain: WBStrain00054984
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (23)
    Structured_description: Concise_description: ify-1 encodes a rapidly evolving protein ligand of FZY-1, with only 53% identity between C. elegans and C. briggsae and with no visible homologs in more distant species; IFY-1 binds FZY-1 and SEP-1 in yeast two-hybrid assays; ify-1(RNAi) and sep-1(RNAi) animals arrest as one-cell embryos with disorganized chromosomes, supporting the hypothesis that IFY-1 is a securin; the fzy-1(h1983) mutation blocks FZY-1 binding to IFY-1, but not to MDF-2, another possible FZY-1 ligand; IFY-1 protein accumulates abnormally in developmentally arrested one-cell emb-30 embryos. Paper_evidence: WBPaper00005604
          Curator_confirmed: WBPerson567
          Date_last_updated: 02 Oct 2006 00:00:00
      Automated_description: Enables protease binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cortical granule exocytosis; nuclear division; and protein stabilization. Located in condensed chromosome; cytoplasm; and spindle microtubule. Expressed in germ cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C27A2.3
    Corresponding_transcript: C27A2.3.1
    Other_sequence: FD514623.1
      CBC03920_1
      CSC01498_1
    Associated_feature: WBsf650034
      WBsf650035
      WBsf987790
      WBsf1012176
      WBsf222993
      WBsf222994
  Experimental_info: RNAi_result (38)
    Expr_pattern: Expr10983
      Expr1022694
      Expr1031221
      Expr1145344
      Expr1200196
      Expr2012702
      Expr2030938
    Drives_construct: WBCnstr00017597
      WBCnstr00036479
    Construct_product: WBCnstr00009266
      WBCnstr00017307
      WBCnstr00017597
      WBCnstr00017616
      WBCnstr00036479
    Antibody: WBAntibody00000990
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_lin-35
      WBPaper00037682:sma-2_sma-4_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055648:sperm_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_12h_regulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_protein
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:ADA_ADE_grandparent
      WBPaper00061340:ADL_parent
      WBPaper00061340:ASE_parent
      WBPaper00061340:AVH_parent
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:DVC_parent
      WBPaper00061340:g2_parent
      WBPaper00061340:Germline
      WBPaper00061340:GLR
      WBPaper00061340:I1_parent
      WBPaper00061340:I2_grandparent
      WBPaper00061340:M1_parent
      WBPaper00061340:M4_parent
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:Neuroblast_PVC_LUA
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_exc_gland_AVK
      WBPaper00061340:Parent_of_hyp3_ILsoDx
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:PVQ_parent
      WBPaper00061340:RIC_parent
      WBPaper00061340:RID_parent
      WBPaper00061340:RIM_parent
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061651:Germline_enriched
      WBPaper00062056:dpl-1(n2994)_upregulated
      WBPaper00062056:efl-1(se1)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(n766)_upregulated
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062056:lin-37(n758)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062237:dnj-21(RNAi)_downregulated_protein
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_10
      WBPaper00025032:cluster_3
      WBPaper00026629:L2_male_enriched
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_A
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037695:LD_3-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:cluster_3
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction: WBInteraction000030894
      WBInteraction000134051
      WBInteraction000135547
      WBInteraction000135548
      WBInteraction000136870
      WBInteraction000136871
      WBInteraction000145098
      WBInteraction000151773
      WBInteraction000159868
      WBInteraction000168868
      WBInteraction000189324
      WBInteraction000190033
      WBInteraction000190699
      WBInteraction000200682
      WBInteraction000203086
      WBInteraction000208360
      WBInteraction000211725
      WBInteraction000213839
      WBInteraction000232856
      WBInteraction000252386
      WBInteraction000254198
      WBInteraction000260234
      WBInteraction000262221
      WBInteraction000271231
      WBInteraction000276958
      WBInteraction000283807
      WBInteraction000285028
      WBInteraction000290497
      WBInteraction000291861
      WBInteraction000296132
      WBInteraction000315052
      WBInteraction000328956
      WBInteraction000338494
      WBInteraction000343551
      WBInteraction000343770
      WBInteraction000346440
      WBInteraction000346809
      WBInteraction000349721
      WBInteraction000350850
      WBInteraction000358066
      WBInteraction000360048
      WBInteraction000362328
      WBInteraction000363987
      WBInteraction000366315
      WBInteraction000368216
      WBInteraction000368746
      WBInteraction000368912
      WBInteraction000374975
      WBInteraction000375931
      WBInteraction000379274
      WBInteraction000379975
      WBInteraction000380353
      WBInteraction000384179
      WBInteraction000393046
      WBInteraction000393829
      WBInteraction000394907
      WBInteraction000400455
      WBInteraction000401227
      WBInteraction000404510
      WBInteraction000408914
      WBInteraction000409696
      WBInteraction000412102
      WBInteraction000412437
      WBInteraction000415139
      WBInteraction000416808
      WBInteraction000417566
      WBInteraction000419519
      WBInteraction000427845
      WBInteraction000428525
      WBInteraction000431267
      WBInteraction000431557
      WBInteraction000432643
      WBInteraction000432702
      WBInteraction000435118
      WBInteraction000437027
      WBInteraction000441047
      WBInteraction000441880
      WBInteraction000444208
      WBInteraction000451275
      WBInteraction000451903
      WBInteraction000460567
      WBInteraction000461639
      WBInteraction000512252
      WBInteraction000512253
      WBInteraction000512258
      WBInteraction000512259
      WBInteraction000512260
      WBInteraction000512261
      WBInteraction000520038
      WBInteraction000523805
      WBInteraction000523807
      WBInteraction000542727
      WBInteraction000542760
      WBInteraction000556534
      WBInteraction000556535
      WBInteraction000556971
      WBInteraction000556972
      WBInteraction000585522
  Map_info: Map: II Position: -2.58429 Error: 0.001659
    Positive: Positive_clone: C27A2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene