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WormBase Tree Display for Gene: WBGene00011064

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Name Class

WBGene00011064SMapS_parentSequenceR06C7
IdentityVersion2
NameCGC_nameadsl-1Person_evidenceWBPerson10610
Sequence_nameR06C7.5
Molecular_nameR06C7.5a
R06C7.5a.1
CE06248
R06C7.5b
CE32476
R06C7.5b.1
Other_nameCELE_R06C7.5Accession_evidenceNDBBX284601
Public_nameadsl-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:52WBPerson1971EventImportedInitial conversion from CDS class of WS125
211 Jul 2014 14:45:03WBPerson2970Name_changeCGC_nameadsl-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classadsl
Allele (17)
RNASeq_FPKM (74)
GO_annotation00072773
00072774
00072775
00072776
00072777
00072778
00072779
00072780
00072781
00072782
00072783
00072784
00072785
00072786
00118357
Contained_in_operonCEOP1380
Ortholog (39)
ParalogWBGene00001503Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionThe R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050).Paper_evidenceWBPaper00004637
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency; breast cancer; and prostate cancer. Is an ortholog of human ADSL (adenylosuccinate lyase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050762Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:291)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:291)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:291)
Molecular_infoCorresponding_CDSR06C7.5a
R06C7.5b
Corresponding_CDS_historyR06C7.5:wp90
Corresponding_transcriptR06C7.5a.1
R06C7.5b.1
Other_sequence (67)
Associated_featureWBsf219713
Experimental_infoRNAi_result (18)
Expr_patternExpr1012902
Expr1034859
Expr1155077
Expr2009242
Expr2027479
Drives_constructWBCnstr00030961
Construct_productWBCnstr00030961
Microarray_results (27)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00044037:eat-2_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045729:gld-4(RNAi)_downregulated
WBPaper00045774:clk-1_downregulated
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050015:ifg-1(RNAi)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051404:alg-2(ok304)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053599:female_vs_male_upregulated
WBPaper00053615:SMO-1_target
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056826:SGP_biased
WBPaper00057136:yap-1(ys38)_upregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060683:hlh-11(overexpression)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061340:Neuroblast_M2_M3
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:tars-1-AFFX-r2-3026-5_at
WBPaper00062056:lin-36(we31)_upregulated
WBPaper00062056:lin-36(we36)_upregulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064716:paraquat_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064992:Eugenol_downregulated
WBPaper00065005:sams-3(RNAi)_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065984:pals-17(syb3980)_downregulated
cgc4489_group_4
WBPaper00025032:cluster_34
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00027342:alpha-Synuclein(WT)_upregulated
WBPaper00029437:dcr-1_downregulated
WBPaper00031003:hlh_1_enriched
WBPaper00034757:down_by_oxidative_stress
WBPaper00035588:alg-1(-)_upregulated
WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00039866:ClassComp_daf-19_upregulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
WBPaper00040426:CYD-1_CDK-4_upregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(101_min)
[cgc5767]:expression_class_E_pi(122_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MD_pd(41_min)
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_ME
[cgc6390]:mixed_oogenesis-somatic
Interaction (89)
Map_infoMapIPosition1.85739
PositivePositive_cloneR06C7Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (17)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene