WormBase Tree Display for Gene: WBGene00000099

WBGene00000099 SMap: S_parent: Sequence: B0207
  Identity: Version: 1
    Name: CGC_name: air-2 Person_evidence: WBPerson205
      Sequence_name: B0207.4
      Molecular_name: B0207.4
        B0207.4.1
        CE24761
        B0207.4.2
      Other_name: let-603
        stu-7
        cyk-6
        CELE_B0207.4 Accession_evidence: NDB BX284601
      Public_name: air-2
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: air
    Allele (19)
    Legacy_information: [Hodgkin JA] e2631 hermaphrodites are long, uncoordinated and sterile, usually with a conspicuous constriction in the mid-region of the body. Males grow poorly, male tail very abnormal, ME0.
      [McDowall JS] Sterile adult
      [C.elegansII] h289 : sterile adult (gonad tumorous mass). OA3: h408, h437, h812 (sterile adults). Cloned: partial cosmid rescue (C32E7); rescued to Mel. [KR]
      [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis defects
    Strain: WBStrain00023752
      WBStrain00035642
      WBStrain00004633
      WBStrain00007296
      WBStrain00007300
      WBStrain00034749
      WBStrain00051600
      WBStrain00051601
    RNASeq_FPKM (74)
    GO_annotation (65)
    Ortholog (46)
    Paralog: WBGene00000098 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 i modified in vitro by the GEI-17 E3 SUMO ligase; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. Paper_evidence (12)
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson363
            WBPerson567
          Date_last_updated: 10 Jun 2015 00:00:00
      Automated_description: Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human AURKB (aurora kinase B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:3008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:0070183 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11391)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:8634 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393)
      DOID:2152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
  Molecular_info: Corresponding_CDS: B0207.4
    Corresponding_transcript: B0207.4.1
      B0207.4.2
    Other_sequence (54)
    Associated_feature: WBsf217728
      WBsf217729
  Experimental_info: RNAi_result (63)
    Expr_pattern: Expr1258
      Expr1889
      Expr1902
      Expr8787
      Expr11619
      Expr1025517
      Expr1030049
      Expr1142927
      Expr1200199
      Expr2009278
      Expr2027515
    Drives_construct: WBCnstr00037734
    Construct_product: WBCnstr00000897
      WBCnstr00005318
      WBCnstr00005560
      WBCnstr00014917
      WBCnstr00017655
      WBCnstr00021506
      WBCnstr00037734
    Antibody: WBAntibody00000198
      WBAntibody00000511
      WBAntibody00001492
      WBAntibody00002053
      WBAntibody00002354
      WBAntibody00002454
      WBAntibody00002607
      WBAntibody00002722
      WBAntibody00002782
    Microarray_results (21)
    Expression_cluster (167)
    Interaction: WBInteraction000001310
      WBInteraction000003953
      WBInteraction000009420
      WBInteraction000009565
      WBInteraction000009667
      WBInteraction000028976
      WBInteraction000029245
      WBInteraction000032570
      WBInteraction000032612
      WBInteraction000032749
      WBInteraction000032908
      WBInteraction000033000
      WBInteraction000034075
      WBInteraction000034191
      WBInteraction000034281
      WBInteraction000034328
      WBInteraction000034710
      WBInteraction000034712
      WBInteraction000034772
      WBInteraction000035071
      WBInteraction000035162
      WBInteraction000035235
      WBInteraction000035390
      WBInteraction000035526
      WBInteraction000035534
      WBInteraction000035793
      WBInteraction000035851
      WBInteraction000036075
      WBInteraction000036303
      WBInteraction000036460
      WBInteraction000036464
      WBInteraction000036490
      WBInteraction000036565
      WBInteraction000036952
      WBInteraction000036953
      WBInteraction000036998
      WBInteraction000037056
      WBInteraction000037109
      WBInteraction000037137
      WBInteraction000037138
      WBInteraction000037231
      WBInteraction000037830
      WBInteraction000037849
      WBInteraction000038071
      WBInteraction000038103
      WBInteraction000038104
      WBInteraction000038381
      WBInteraction000038395
      WBInteraction000038731
      WBInteraction000038797
      WBInteraction000038861
      WBInteraction000038874
      WBInteraction000039031
      WBInteraction000039032
      WBInteraction000039239
      WBInteraction000039643
      WBInteraction000039842
      WBInteraction000040006
      WBInteraction000040198
      WBInteraction000040388
      WBInteraction000040461
      WBInteraction000041320
      WBInteraction000041366
      WBInteraction000041653
      WBInteraction000041676
      WBInteraction000041809
      WBInteraction000041843
      WBInteraction000041855
      WBInteraction000041894
      WBInteraction000042017
      WBInteraction000042021
      WBInteraction000042502
      WBInteraction000042998
      WBInteraction000043032
      WBInteraction000043484
      WBInteraction000043718
      WBInteraction000043756
      WBInteraction000044426
      WBInteraction000044457
      WBInteraction000045127
      WBInteraction000045152
      WBInteraction000045379
      WBInteraction000045449
      WBInteraction000045520
      WBInteraction000045677
      WBInteraction000046571
      WBInteraction000046688
      WBInteraction000046689
      WBInteraction000046788
      WBInteraction000046898
      WBInteraction000047560
      WBInteraction000047706
      WBInteraction000047707
      WBInteraction000047892
      WBInteraction000048601
      WBInteraction000048809
      WBInteraction000049375
      WBInteraction000049608
      WBInteraction000049641
      WBInteraction000049654
      WBInteraction000050474
      WBInteraction000050491
      WBInteraction000050492
      WBInteraction000050631
      WBInteraction000050632
      WBInteraction000050633
      WBInteraction000051383
      WBInteraction000051730
      WBInteraction000110730
      WBInteraction000111160
      WBInteraction000111915
      WBInteraction000112420
      WBInteraction000112561
      WBInteraction000114329
      WBInteraction000115792
      WBInteraction000120468
      WBInteraction000121200
      WBInteraction000121201
      WBInteraction000121402
      WBInteraction000126982
      WBInteraction000127605
      WBInteraction000127606
      WBInteraction000127607
      WBInteraction000127608
      WBInteraction000127609
      WBInteraction000127610
      WBInteraction000127611
      WBInteraction000127612
      WBInteraction000127613
      WBInteraction000127614
      WBInteraction000127615
      WBInteraction000134404
      WBInteraction000139363
      WBInteraction000140418
      WBInteraction000144299
      WBInteraction000144300
      WBInteraction000153214
      WBInteraction000159899
      WBInteraction000164542
      WBInteraction000164543
      WBInteraction000164544
      WBInteraction000164545
      WBInteraction000164546
      WBInteraction000164547
      WBInteraction000164548
      WBInteraction000164549
      WBInteraction000164550
      WBInteraction000164551
      WBInteraction000164552
      WBInteraction000164553
      WBInteraction000164554
      WBInteraction000164555
      WBInteraction000165470
      WBInteraction000169054
      WBInteraction000171188
      WBInteraction000172869
      WBInteraction000172870
      WBInteraction000195343
      WBInteraction000208461
      WBInteraction000209462
      WBInteraction000217881
      WBInteraction000217882
      WBInteraction000227188
      WBInteraction000254625
      WBInteraction000263139
      WBInteraction000270654
      WBInteraction000277828
      WBInteraction000282204
      WBInteraction000292365
      WBInteraction000296599
      WBInteraction000310058
      WBInteraction000317266
      WBInteraction000320273
      WBInteraction000328956
      WBInteraction000338347
      WBInteraction000353822
      WBInteraction000353967
      WBInteraction000357932
      WBInteraction000361254
      WBInteraction000375200
      WBInteraction000380645
      WBInteraction000383886
      WBInteraction000391908
      WBInteraction000396198
      WBInteraction000405107
      WBInteraction000405832
      WBInteraction000413291
      WBInteraction000418073
      WBInteraction000420956
      WBInteraction000424564
      WBInteraction000429665
      WBInteraction000432606
      WBInteraction000439850
      WBInteraction000446672
      WBInteraction000466605
      WBInteraction000472790
      WBInteraction000500945
      WBInteraction000500948
      WBInteraction000500953
      WBInteraction000501681
      WBInteraction000501683
      WBInteraction000501783
      WBInteraction000502011
      WBInteraction000502012
      WBInteraction000502245
      WBInteraction000502246
      WBInteraction000502875
      WBInteraction000503812
      WBInteraction000518653
      WBInteraction000518947
      WBInteraction000522365
      WBInteraction000522366
      WBInteraction000522367
      WBInteraction000522368
      WBInteraction000522405
      WBInteraction000523110
      WBInteraction000539870
      WBInteraction000540328
      WBInteraction000540342
      WBInteraction000540899
      WBInteraction000541079
      WBInteraction000541386
      WBInteraction000542856
      WBInteraction000550310
      WBInteraction000550311
      WBInteraction000550915
      WBInteraction000551382
      WBInteraction000551394
      WBInteraction000554692
      WBInteraction000556107
      WBInteraction000556152
      WBInteraction000556290
      WBInteraction000556291
      WBInteraction000556549
      WBInteraction000556763
      WBInteraction000557581
      WBInteraction000557582
      WBInteraction000557584
      WBInteraction000557585
      WBInteraction000557586
      WBInteraction000557587
      WBInteraction000557588
      WBInteraction000557927
      WBInteraction000557930
      WBInteraction000558107
      WBInteraction000558110
      WBInteraction000558117
      WBInteraction000558118
      WBInteraction000558119
      WBInteraction000558120
      WBInteraction000558121
      WBInteraction000558124
      WBInteraction000558571
      WBInteraction000558573
      WBInteraction000585550
      WBInteraction000585551
  Map_info: Map: I Position: 0.482005 Error: 0.002155
    Well_ordered
    Positive: Positive_clone: B0207 Inferred_automatically: From sequence, transcript, pseudogene data
        C32E7
    Negative: Outside_rearr: hDf29
      Negative_clone: C03E6
        C04F1
        C07F10
        C30B6
        C53A11
    Mapping_data: 2_point: 5225
        5226
      Multi_point: 3520
        3865
        4380
        4601
      Pos_neg_data (12)
  Reference (120)
  Remark: [McDowall JS] Extrachromosomal array containing single cosmid generated, then manipulated genetically. Partial rescue: normally sterile adult with tumorous mass, develops to tumorless egg-laying adult, eggs do not develop or hatch.
    testing swap around with sup-40, from 0.435 to 0.575
    same as cyk-6 according to cgc4544 and email 114.
    same as air-2 according to cgc4544 and email 114.
    old_name cyk-6 becomes new_name air-2 from [Woollard A, Hodgkin JA, Schumacher J].
    old_names let-603 and stu-7 had previously been identitifed with air-2.
  Method: Gene