WormBase Tree Display for Gene: WBGene00000467
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| WBGene00000467 | SMap | S_parent | Sequence | F52B5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cep-1 | Person_evidence | WBPerson539 | |||||
| Sequence_name | F52B5.5 | ||||||||
| Molecular_name | F52B5.5a | ||||||||
| F52B5.5a.1 | |||||||||
| CE29805 | |||||||||
| F52B5.5b | |||||||||
| CE38369 | |||||||||
| F52B5.5b.1 | |||||||||
| F52B5.5b.2 | |||||||||
| F52B5.5b.3 | |||||||||
| F52B5.5b.4 | |||||||||
| Other_name | CELE_F52B5.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | cep-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00000467 | |||||
| WormFlux | gene | WBGene00000467 | |||||||
| NDB | locus_tag | CELE_F52B5.5 | |||||||
| NCBI | gene | 172616 | |||||||
| RefSeq | protein | NM_001026307.8 | |||||||
| NM_001392668.1 | |||||||||
| SwissProt | UniProtAcc | Q20646 | |||||||
| UniProt_GCRP | UniProtAcc | Q20646 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cep | ||||||||
| Allele (54) | |||||||||
| Strain | WBStrain00022753 | ||||||||
| WBStrain00034662 | |||||||||
| WBStrain00034663 | |||||||||
| WBStrain00034811 | |||||||||
| WBStrain00035557 | |||||||||
| WBStrain00040683 | |||||||||
| WBStrain00004786 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (45) | |||||||||
| Ortholog (17) | |||||||||
| Structured_description | Concise_description | cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. | Paper_evidence | WBPaper00004589 | |||||
| WBPaper00004919 | |||||||||
| WBPaper00004952 | |||||||||
| WBPaper00012759 | |||||||||
| WBPaper00012806 | |||||||||
| WBPaper00013586 | |||||||||
| WBPaper00013634 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables several functions, including DNA-binding transcription factor activity; protein homodimerization activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Located in germ cell nucleus; nucleolus; and nucleoplasm. Expressed in Z2; Z3; germ line; pharyngeal cell; and pharynx. Used to study cancer. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00004952 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Feb 2020 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000735 | ||||||||
| Molecular_info (7) | |||||||||
| Experimental_info | RNAi_result (50) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00010364 | ||||||||
| WBCnstr00014694 | |||||||||
| WBCnstr00015210 | |||||||||
| WBCnstr00018639 | |||||||||
| WBCnstr00037515 | |||||||||
| Construct_product | WBCnstr00005243 | ||||||||
| WBCnstr00010364 | |||||||||
| WBCnstr00014694 | |||||||||
| WBCnstr00015953 | |||||||||
| WBCnstr00018639 | |||||||||
| WBCnstr00018675 | |||||||||
| WBCnstr00037515 | |||||||||
| Regulate_expr_cluster | WBPaper00028948:cep-1(gk138)+UV_downregulated | ||||||||
| WBPaper00028948:cep-1(gk138)+UV_upregulated | |||||||||
| WBPaper00028948:cep-1(gk138)_downregulated | |||||||||
| WBPaper00028948:cep-1(gk138)_upregulated | |||||||||
| WBPaper00045380:cep-1(gk138)_downregulated_normal | |||||||||
| WBPaper00045380:cep-1(gk138)_downregulated_UV | |||||||||
| WBPaper00045380:cep-1(gk138)_upregulated_normal | |||||||||
| WBPaper00045380:cep-1(gk138)_upregulated_UV | |||||||||
| Antibody | WBAntibody00000833 | ||||||||
| WBAntibody00001388 | |||||||||
| WBAntibody00001389 | |||||||||
| WBAntibody00002125 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (100) | |||||||||
| Anatomy_function | WBbtf1089 | ||||||||
| WBProcess | WBbiopr:00000013 | ||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000050 | |||||||||
| WBbiopr:00000066 | |||||||||
| WBbiopr:00000091 | |||||||||
| WBbiopr:00000104 | |||||||||
| Map_info | Map | I | Position | 2.73569 | Error | 0.00602 | |||
| Positive | Positive_clone | F52B5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4212 | |||||||
| 4897 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (251) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| [wm99ab616], [wm2001p535] and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog. | |||||||||
| Method | Gene |
