WormBase Tree Display for Gene: WBGene00006788
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WBGene00006788 | SMap | S_parent | Sequence | CHROMOSOME_II | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143183 | ||||||
Allele (424) | |||||||
Legacy_information | e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569). | ||||||
See also e2432, e2499, n152, n166, n569 | |||||||
[C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG] | |||||||
Strain | WBStrain00026706 | ||||||
WBStrain00026870 | |||||||
WBStrain00032757 | |||||||
WBStrain00034470 | |||||||
WBStrain00034483 | |||||||
WBStrain00037045 | |||||||
WBStrain00004162 | |||||||
WBStrain00004572 | |||||||
WBStrain00005655 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00007033 | ||||||
00007034 | |||||||
00007035 | |||||||
00007036 | |||||||
00007037 | |||||||
00007038 | |||||||
00007039 | |||||||
00007040 | |||||||
00007041 | |||||||
00007042 | |||||||
00007043 | |||||||
00007044 | |||||||
00007045 | |||||||
00007046 | |||||||
00007047 | |||||||
00007048 | |||||||
00082483 | |||||||
00082484 | |||||||
00082485 | |||||||
00082486 | |||||||
00114827 | |||||||
Ortholog (46) | |||||||
Structured_description | Concise_description | unc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. | Paper_evidence (11) | ||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 13 Nov 2012 00:00:00 | ||||||
Automated_description | Predicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Is an ortholog of human NAV1 (neuron navigator 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:2559 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15998) | ||
Molecular_info | Corresponding_CDS | F45E10.1a | |||||
F45E10.1b | |||||||
F45E10.1c | |||||||
F45E10.1d | |||||||
F45E10.1e | |||||||
F45E10.1f | |||||||
F45E10.1g | |||||||
F45E10.1h | |||||||
Corresponding_CDS_history | F45E10.1:wp82 | ||||||
Corresponding_transcript | F45E10.1a.1 | ||||||
F45E10.1b.1 | |||||||
F45E10.1c.1 | |||||||
F45E10.1d.1 | |||||||
F45E10.1e.1 | |||||||
F45E10.1f.1 | |||||||
F45E10.1g.1 | |||||||
F45E10.1h.1 | |||||||
Other_sequence (27) | |||||||
Associated_feature (66) | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00000584 | ||||||
WBCnstr00003503 | |||||||
WBCnstr00006230 | |||||||
WBCnstr00006723 | |||||||
WBCnstr00006972 | |||||||
WBCnstr00007215 | |||||||
WBCnstr00007218 | |||||||
WBCnstr00007219 | |||||||
WBCnstr00007220 | |||||||
WBCnstr00007221 | |||||||
WBCnstr00007222 | |||||||
WBCnstr00007223 | |||||||
WBCnstr00007231 | |||||||
WBCnstr00007232 | |||||||
WBCnstr00009444 | |||||||
WBCnstr00010519 | |||||||
WBCnstr00010520 | |||||||
WBCnstr00010521 | |||||||
WBCnstr00013360 | |||||||
WBCnstr00014513 | |||||||
WBCnstr00017891 | |||||||
WBCnstr00018126 | |||||||
WBCnstr00018231 | |||||||
WBCnstr00022873 | |||||||
WBCnstr00034150 | |||||||
Construct_product | WBCnstr00009444 | ||||||
WBCnstr00010519 | |||||||
WBCnstr00010520 | |||||||
WBCnstr00010521 | |||||||
WBCnstr00034150 | |||||||
Antibody | WBAntibody00001615 | ||||||
WBAntibody00001625 | |||||||
Microarray_results (40) | |||||||
Expression_cluster (219) | |||||||
Interaction (103) | |||||||
Anatomy_function | WBbtf0113 | ||||||
WBbtf0114 | |||||||
WBbtf0118 | |||||||
WBbtf0119 | |||||||
Map_info | Map | II | Position | 3.16568 | Error | 0.005694 | |
Well_ordered | |||||||
Positive | Positive_clone | F45E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
T28D2 | |||||||
Mapping_data | 2_point | 43 | |||||
Multi_point (11) | |||||||
Pos_neg_data | 2145 | ||||||
2146 | |||||||
2159 | |||||||
2163 | |||||||
4533 | |||||||
4534 | |||||||
4535 | |||||||
4536 | |||||||
4539 | |||||||
10562 | |||||||
Reference (99) | |||||||
Method | Gene |