WormBase Tree Display for Gene: WBGene00006385
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WBGene00006385 | SMap | S_parent | Sequence | R119 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | taf | ||||||
Allele (124) | |||||||
Strain | WBStrain00036170 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (40) | |||||||
Structured_description | Concise_description | taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis. | Paper_evidence | WBPaper00004890 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 26 Jan 2005 00:00:00 | ||||||
Automated_description | Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including determination of adult lifespan; regulation of mitotic cell cycle, embryonic; and transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Is an ortholog of human TAF4B (TATA-box binding protein associated factor 4b). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0070182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11538) | ||
Molecular_info | Corresponding_CDS | R119.6 | |||||
Corresponding_CDS_history | R119.6:wp153 | ||||||
Corresponding_transcript | R119.6.1 | ||||||
Other_sequence (39) | |||||||
Associated_feature | WBsf643011 | ||||||
WBsf980924 | |||||||
WBsf982485 | |||||||
WBsf1009079 | |||||||
WBsf217127 | |||||||
WBsf217128 | |||||||
Transcription_factor | WBTranscriptionFactor000206 | ||||||
WBTranscriptionFactor000442 | |||||||
Experimental_info | RNAi_result (40) | ||||||
Expr_pattern | Expr1027683 | ||||||
Expr1032582 | |||||||
Expr1155419 | |||||||
Expr2017214 | |||||||
Expr2035350 | |||||||
Construct_product | WBCnstr00005322 | ||||||
WBCnstr00005323 | |||||||
Antibody | WBAntibody00000409 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (84) | |||||||
Interaction (90) | |||||||
Map_info | Map | I | Position | -19.0465 | Error | 0.003066 | |
Positive | Positive_clone | R119 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (17) | |||||||
Remark | Sequence connection from [source: A Walker] | ||||||
This gene was previously called taf-5. [krb 020614] | |||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |