WormBase Tree Display for Gene: WBGene00003997
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WBGene00003997 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | pgp-3 | Person_evidence | WBPerson490 | |||||
Sequence_name | ZK455.7 | ||||||||
Molecular_name | ZK455.7 | ||||||||
ZK455.7.1 | |||||||||
CE03818 | |||||||||
Other_name | cepgpC | Accession_evidence | EMBL | X65055 | |||||
CELE_ZK455.7 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | pgp-3 | ||||||||
DB_info | Database | AceView | gene | XL973 | |||||
WormQTL | gene | WBGene00003997 | |||||||
WormFlux | gene | WBGene00003997 | |||||||
NDB | locus_tag | CELE_ZK455.7 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003997|UniProtKB=P34713 | |||||||
family | PTHR24221 | ||||||||
NCBI | gene | 181326 | |||||||
RefSeq | protein | NM_077500.5 | |||||||
KEGG | KEGG_id | 7.6.2.2 | |||||||
NemaPath | KEGG_id | 7.6.2.2 | |||||||
SwissProt | UniProtAcc | P34713 | |||||||
UniProt_GCRP | UniProtAcc | P34713 | |||||||
OMIM | gene | 171050 | |||||||
171060 | |||||||||
603201 | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | pgp | ||||||||
Allele (77) | |||||||||
Legacy_information | [C.elegansII] pk18 : deletion derived from pk30tci, increased sensitivity to colchicine and to chloroquine; gross phenotype WT. Cloned: encodes 1254 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins. Transcripts present throughout development; pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-3 detected in apical membranes of gut and of excretory cell. [Broeks et al. 1995; NL] | ||||||||
Strain | WBStrain00028887 | ||||||||
WBStrain00028888 | |||||||||
WBStrain00028891 | |||||||||
WBStrain00033025 | |||||||||
WBStrain00037266 | |||||||||
WBStrain00004731 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (71) | |||||||||
Paralog (23) | |||||||||
Structured_description | Concise_description | pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells. | Paper_evidence | WBPaper00002180 | |||||
WBPaper00003366 | |||||||||
WBPaper00003925 | |||||||||
WBPaper00004651 | |||||||||
WBPaper00005654 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 03 Apr 2014 00:00:00 | ||||||||
Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Expressed in excretory canal; excretory cell; intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (41) | ||||||||
Molecular_info | Corresponding_CDS | ZK455.7 | |||||||
Corresponding_transcript | ZK455.7.1 | ||||||||
Other_sequence | AJ577782.1 | ||||||||
Acan_isotig15536 | |||||||||
GR978971.1 | |||||||||
Oden_isotig20479 | |||||||||
ES880390.1 | |||||||||
PPC07546_1 | |||||||||
JI213191.1 | |||||||||
HM635768.1 | |||||||||
MH02620 | |||||||||
ACC26020_1 | |||||||||
Tcir_isotig04372 | |||||||||
Tcol_isotig26711 | |||||||||
EY471681.1 | |||||||||
EX562340.1 | |||||||||
HM635772.1 | |||||||||
AJ577799.1 | |||||||||
ES410195.1 | |||||||||
SC00408 | |||||||||
HBC06719_1 | |||||||||
Name_isotig04888 | |||||||||
HM635766.1 | |||||||||
Associated_feature | WBsf1006975 | ||||||||
Experimental_info | RNAi_result | WBRNAi00059437 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022018 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00014821 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00001488 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (13) | |||||||||
Drives_construct | WBCnstr00002142 | ||||||||
WBCnstr00010331 | |||||||||
WBCnstr00011338 | |||||||||
WBCnstr00011339 | |||||||||
WBCnstr00012125 | |||||||||
WBCnstr00012126 | |||||||||
WBCnstr00012634 | |||||||||
WBCnstr00015310 | |||||||||
WBCnstr00035753 | |||||||||
Construct_product | WBCnstr00012634 | ||||||||
WBCnstr00014565 | |||||||||
WBCnstr00014566 | |||||||||
WBCnstr00035753 | |||||||||
Antibody | WBAntibody00000095 | ||||||||
Microarray_results (17) | |||||||||
Expression_cluster (180) | |||||||||
Interaction (34) | |||||||||
Map_info | Map | X | Position | 3.16596 | Error | 0.03869 | |||
Positive | Positive_clone | PB#CPG4 | |||||||
ZK455 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||||
Reference (46) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |