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WormBase Tree Display for Gene: WBGene00004036

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Name Class

WBGene00004036SMapS_parentSequenceCHROMOSOME_X
IdentityVersion2
NameCGC_nameplc-1Person_evidenceWBPerson51
WBPerson1983
Sequence_nameF31B12.1
Molecular_name (36)
Other_namePLC210Paper_evidenceWBPaper00003022
WBPaper00003365
WBPaper00003875
WBPaper00003432
WBPaper00023291
frm-9Curator_confirmedWBPerson4025
CELE_F31B12.1Accession_evidenceNDBBX284606
Public_nameplc-1
DB_infoDatabaseAceViewgeneXL414
WormQTLgeneWBGene00004036
WormFluxgeneWBGene00004036
NDBlocus_tagCELE_F31B12.1
PanthergeneCAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8
familyPTHR10336
NCBIgene181274
RefSeqprotein (12)
KEGGKEGG_id3.1.4.11
NemaPathKEGG_id3.1.4.11
SwissProtUniProtAccG5EFI8
TREEFAMTREEFAM_IDTF314432
TrEMBLUniProtAccG5EFG8
A0A4V0IJW2
A0A4V0IMY5
A0A4V0IN51
A0A4V0IK11
A0A4V6M3C0
A0A4V0IKD8
UniProt_GCRPUniProtAccG5EFI8
OMIMgene608414
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
220 May 2019 14:10:26WBPerson1983Name_change (2)
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classplc
Allele (621)
StrainWBStrain00002612
WBStrain00030932
WBStrain00030933
WBStrain00051732
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (36)
ParalogWBGene00001177Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004045Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004037Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004039Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004038Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionplc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras.Paper_evidenceWBPaper00003022
WBPaper00023291
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3717Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17175)
DOID:0080379Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17175)
DOID:1184Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17175)
DOID:0080382Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17175)
Molecular_infoCorresponding_CDS (12)
Corresponding_CDS_historyF31B12.1a:wp40
F31B12.1b:wp40
F31B12.1b:wp52
Corresponding_transcript (12)
Other_sequence (49)
Associated_feature (13)
Experimental_infoRNAi_result (25)
Expr_pattern (11)
Drives_constructWBCnstr00000769
WBCnstr00003170
WBCnstr00006426
WBCnstr00018194
WBCnstr00035730
Construct_productWBCnstr00006426
WBCnstr00035730
Microarray_resultsSMD_C05A9.3
SMD_F31B12.1
SMD_F31B12.2
SMD_F31B12.3
172720_x_at
172914_x_at
173954_at
175735_at
181068_at
184178_at
188827_at
A_12_P102350
A_12_P106878
A_12_P107535
A_12_P117958
A_12_P154335
A_12_P154336
Aff_C05A9.3
Aff_F31B12.1
Aff_F31B12.2
Aff_F31B12.3
GPL13394_WBGene00004036
GPL13394_WBGene00007318
GPL13394_WBGene00009282
GPL13914_C05A9.3
GPL13914_F31B12.1
GPL13914_F31B12.2
GPL14144_C05A9.3_1133-1192_0.947_1_A
GPL14144_C05A9.3_1170-1229_0.841_45_C
GPL14144_C05A9.3_508-567_0.876_25_B
GPL14144_F31B12.1a_5294-5353_0.934_4_B
GPL14144_F31B12.1a_5404-5463_0.931_5_C
GPL14144_F31B12.1a_5621-5680_0.945_1_A
GPL14144_F31B12.3_480-539_0.926_5_C
GPL14144_F31B12.3_748-807_0.932_3_B
GPL14144_F31B12.3_993-1052_0.942_1_A
GPL19516_CGZ0019027
GPL19516_CGZ0019028
GPL19516_CGZ0019029
GPL19516_CGZ0019030
GPL19516_CGZ0019031
GPL19516_CGZ0019032
GPL19516_CGZ0019033
GPL19516_CGZ0019034
GPL19516_CGZ0019035
GPL19516_CGZ0019036
GPL21109_F31B12.1a
GPL21109_F31B12.1b
GPL21109_F31B12.1c
GPL21109_F31B12.3a
GPL21109_F31B12.3b
GPL21109_F31B12.3d
GPL3518_CE03282
GPL3518_CE03283
GPL3518_CE05223
GPL3518_CE28227
GPL3518_CE31494
GPL8304_CE_WBGene00004036_A
GPL8304_CE_WBGene00007318_A
GPL8673_C05A9_3P00744
GPL8673_C05A9_3P00851
GPL8673_F31B12_1aP04626
GPL8673_F31B12_1aP04897
GPL8673_F31B12_1aP05405
GPL8673_F31B12_1bP04626
GPL8673_F31B12_1bP04897
GPL8673_F31B12_1bP05523
GPL8673_F31B12_1cP04626
GPL8673_F31B12_1cP04897
GPL8673_F31B12_1cP05620
GPL8673_F31B12_2P01837
GPL8673_F31B12_2P02474
GPL8673_F31B12_2P02741
GPL8673_F31B12_3P00498
GPL8673_F31B12_3P00678
GPL9450_C05A9.3
GPL9450_F31B12.1a
GPL9450_F31B12.1b
GPL9450_F31B12.1c
GPL9450_F31B12.2
cea2.d.07884
cea2.i.49939
cea2.p.142941
cea2.p.143013
cea2.p.143036
Expression_cluster (182)
Interaction (14)
WBProcessWBbiopr:00000067
Map_infoMapXPosition2.53988Error0.004789
PositivePositive_cloneF31B12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (40)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene