WormBase Tree Display for Gene: WBGene00003784

WBGene00003784 SMap: S_parent: Sequence: ZK1127
  Identity: Version: 1
    Name: CGC_name: nos-2 Person_evidence: WBPerson575
      Sequence_name: ZK1127.1
      Molecular_name: ZK1127.1
        ZK1127.1.1
        CE05121
      Other_name: CELE_ZK1127.1 Accession_evidence: NDB BX284602
      Public_name: nos-2
    DB_info: Database: AceView gene 2H357
        WormQTL gene WBGene00003784
        WormFlux gene WBGene00003784
        NDB locus_tag CELE_ZK1127.1
        Panther gene CAEEL|WormBase=WBGene00003784|UniProtKB=Q23406
          family PTHR12887
        NCBI gene 174158
        RefSeq protein NM_063051.7
        TREEFAM TREEFAM_ID TF318878
        TrEMBL UniProtAcc Q23406
        UniProt_GCRP UniProtAcc Q23406
        OMIM gene 608226
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nos
    Allele (22)
    Legacy_information: [Seydoux G] No mutants known. Encodes protein with similarity to Drosophila nanos. Predicted gene ZK1127.1
    Strain: WBStrain00022251
      WBStrain00003947
      WBStrain00022439
      WBStrain00022445
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (19)
    Paralog: WBGene00003783 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020167 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
    Structured_description: Concise_description: nos-2 encodes one of three genes in C. elegans that contains a putative zinc-binding domain similar to the one found in Drosophila nanos; nos-2 affects incorporation of primordial germ cells into the somatic gonad, is required redundantly with nos-1 to prevent primordial germ cells from dividing in starved animals and to maintain germ cell viability during larval development in hermaphrodites and in males, and also functions together with nos-1 and nos-3 in the hermaphrodite switch from spermatogenesis to oogenesis; nos-2 is expressed in the primordial germ cells around the time of gastrulation from a maternal RNA associated with P granules, and it is expressed coordinately with nos-1in a dynamic fashion until the embryonic 200-cell stage. Paper_evidence: WBPaper00003692
            WBPaper00003762
            WBPaper00004672
          Curator_confirmed: WBPerson48
          Date_last_updated: 11 Mar 2005 00:00:00
      Automated_description: Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070171 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23044)
  Molecular_info: Corresponding_CDS: ZK1127.1
    Corresponding_transcript: ZK1127.1.1
    Other_sequence: CJC04685_1
      CJC06275_1
      CSC01626_1
      CBC00647_1
      FD515793.1
      CR01356
      CRC01394_1
    Associated_feature (14)
  Experimental_info: RNAi_result (41)
    Expr_pattern: Expr1159
      Expr1161
      Expr1031770
      Expr1162550
      Expr2014357
      Expr2032598
    Drives_construct: WBCnstr00035869
    Construct_product: WBCnstr00035869
    Antibody: WBAntibody00000247
    Microarray_results (29)
    Expression_cluster (190)
    Interaction: WBInteraction000000938
      WBInteraction000000959
      WBInteraction000003398
      WBInteraction000008620
      WBInteraction000009150
      WBInteraction000028262
      WBInteraction000028264
      WBInteraction000028265
      WBInteraction000050658
      WBInteraction000050659
      WBInteraction000051960
      WBInteraction000103435
      WBInteraction000109551
      WBInteraction000110485
      WBInteraction000111921
      WBInteraction000113057
      WBInteraction000115794
      WBInteraction000120815
      WBInteraction000124740
      WBInteraction000126612
      WBInteraction000126845
      WBInteraction000134858
      WBInteraction000136163
      WBInteraction000139003
      WBInteraction000141539
      WBInteraction000143944
      WBInteraction000145132
      WBInteraction000145199
      WBInteraction000147209
      WBInteraction000150558
      WBInteraction000151195
      WBInteraction000159869
      WBInteraction000160166
      WBInteraction000160365
      WBInteraction000163659
      WBInteraction000164679
      WBInteraction000165436
      WBInteraction000166180
      WBInteraction000171710
      WBInteraction000172803
      WBInteraction000176217
      WBInteraction000177732
      WBInteraction000180149
      WBInteraction000180187
      WBInteraction000180415
      WBInteraction000181079
      WBInteraction000181659
      WBInteraction000183831
      WBInteraction000184445
      WBInteraction000184570
      WBInteraction000188112
      WBInteraction000188187
      WBInteraction000188593
      WBInteraction000188862
      WBInteraction000188890
      WBInteraction000191202
      WBInteraction000192391
      WBInteraction000192530
      WBInteraction000192742
      WBInteraction000195547
      WBInteraction000196473
      WBInteraction000197417
      WBInteraction000199888
      WBInteraction000201578
      WBInteraction000202313
      WBInteraction000202862
      WBInteraction000203363
      WBInteraction000204794
      WBInteraction000210695
      WBInteraction000211089
      WBInteraction000211096
      WBInteraction000212028
      WBInteraction000214119
      WBInteraction000216561
      WBInteraction000221883
      WBInteraction000225607
      WBInteraction000225614
      WBInteraction000226912
      WBInteraction000228619
      WBInteraction000230602
      WBInteraction000231192
      WBInteraction000231759
      WBInteraction000232487
      WBInteraction000233618
      WBInteraction000236012
      WBInteraction000236341
      WBInteraction000245486
      WBInteraction000247724
      WBInteraction000247999
      WBInteraction000254043
      WBInteraction000255491
      WBInteraction000258225
      WBInteraction000261590
      WBInteraction000261875
      WBInteraction000262141
      WBInteraction000262327
      WBInteraction000266456
      WBInteraction000268054
      WBInteraction000268735
      WBInteraction000268765
      WBInteraction000272221
      WBInteraction000273042
      WBInteraction000274813
      WBInteraction000277432
      WBInteraction000277539
      WBInteraction000280185
      WBInteraction000283957
      WBInteraction000285047
      WBInteraction000286399
      WBInteraction000287232
      WBInteraction000289055
      WBInteraction000290431
      WBInteraction000293980
      WBInteraction000294476
      WBInteraction000300262
      WBInteraction000300631
      WBInteraction000300652
      WBInteraction000301013
      WBInteraction000301245
      WBInteraction000304770
      WBInteraction000306275
      WBInteraction000307978
      WBInteraction000310083
      WBInteraction000311071
      WBInteraction000313951
      WBInteraction000314437
      WBInteraction000314972
      WBInteraction000316013
      WBInteraction000316416
      WBInteraction000317424
      WBInteraction000321588
      WBInteraction000323578
      WBInteraction000325498
      WBInteraction000326639
      WBInteraction000327244
      WBInteraction000329196
      WBInteraction000331805
      WBInteraction000331902
      WBInteraction000333602
      WBInteraction000334813
      WBInteraction000335650
      WBInteraction000337697
      WBInteraction000338970
      WBInteraction000339445
      WBInteraction000343885
      WBInteraction000344964
      WBInteraction000346366
      WBInteraction000347076
      WBInteraction000347223
      WBInteraction000347636
      WBInteraction000347922
      WBInteraction000349660
      WBInteraction000350186
      WBInteraction000351023
      WBInteraction000353207
      WBInteraction000355251
      WBInteraction000357301
      WBInteraction000360128
      WBInteraction000367657
      WBInteraction000367890
      WBInteraction000368950
      WBInteraction000370196
      WBInteraction000371666
      WBInteraction000372879
      WBInteraction000373855
      WBInteraction000374875
      WBInteraction000374936
      WBInteraction000376346
      WBInteraction000377367
      WBInteraction000383028
      WBInteraction000383684
      WBInteraction000383873
      WBInteraction000384999
      WBInteraction000386784
      WBInteraction000392563
      WBInteraction000393242
      WBInteraction000397728
      WBInteraction000398047
      WBInteraction000400060
      WBInteraction000400681
      WBInteraction000401938
      WBInteraction000406444
      WBInteraction000406552
      WBInteraction000409440
      WBInteraction000410509
      WBInteraction000412159
      WBInteraction000412722
      WBInteraction000413762
      WBInteraction000415139
      WBInteraction000415458
      WBInteraction000415857
      WBInteraction000423304
      WBInteraction000424181
      WBInteraction000425171
      WBInteraction000427738
      WBInteraction000428744
      WBInteraction000430178
      WBInteraction000433598
      WBInteraction000435222
      WBInteraction000439403
      WBInteraction000439807
      WBInteraction000440573
      WBInteraction000440840
      WBInteraction000444452
      WBInteraction000448604
      WBInteraction000450689
      WBInteraction000450957
      WBInteraction000451866
      WBInteraction000452197
      WBInteraction000453361
      WBInteraction000454430
      WBInteraction000455660
      WBInteraction000457659
      WBInteraction000459042
      WBInteraction000459076
      WBInteraction000459887
      WBInteraction000461181
      WBInteraction000500390
      WBInteraction000500410
      WBInteraction000500411
      WBInteraction000500914
      WBInteraction000500916
      WBInteraction000501692
      WBInteraction000503589
      WBInteraction000503590
      WBInteraction000503591
      WBInteraction000503734
      WBInteraction000503735
      WBInteraction000503736
      WBInteraction000503745
      WBInteraction000504355
      WBInteraction000539365
      WBInteraction000541754
      WBInteraction000541755
  Map_info: Map: II Position: 0.381622 Error: 0.021659
    Positive: Positive_clone: ZK1127 Author_evidence: Seydoux GC
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4542
    Pseudo_map_position
  Reference (64)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene